[1]高 飞,杨红玲,王洁琳,等.妊娠期糖尿病患者红细胞分布宽度与胰岛素抵抗的相关性研究[J].现代检验医学杂志,2017,32(01):66-68.[doi:10.3969/j.issn.1671-7414.2017.01.018]
 GAO Fei,YANG Hong-ling,WANG Jie-lin,et al.Relationship between the Red Cell Volume Distribution Width in Patients with Gestational Diabetes and Insulin Resistance[J].Journal of Modern Laboratory Medicine,2017,32(01):66-68.[doi:10.3969/j.issn.1671-7414.2017.01.018]
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妊娠期糖尿病患者红细胞分布宽度与胰岛素抵抗的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
66-68
栏目:
论著
出版日期:
2017-01-25

文章信息/Info

Title:
Relationship between the Red Cell Volume Distribution Width in Patients with Gestational Diabetes and Insulin Resistance
文章编号:
1671-7414(2017)01-066-03
作者:
高 飞杨红玲王洁琳高秀蓉龙 燕郑 浩陈小娟
广州市妇女儿童医疗中心检验科,广州 510623
Author(s):
GAO FeiYANG Hong-lingWANG Jie-linGAO Xiu-rongLONG YanZHENG Hao CHEN Xiao-juan
Department of ClinicalLaboratory, Guangzhou Women and Children's Medical Center,Guangzhou 510623,China
关键词:
妊娠期糖尿病 红细胞分布宽度 胰岛素抵抗
分类号:
R714.25; R446.11
DOI:
10.3969/j.issn.1671-7414.2017.01.018
文献标志码:
A
摘要:
目的 探讨妊娠期糖尿病(GDM)患者红细胞分布宽度(RDW)与胰岛素抵抗(IR)之间的关系。方法 选择2016年1月~10月于广州市妇女儿童医疗中心产科就诊孕妇160例作为研究对象,采用巢式病例对照研究方法,妊娠期糖尿病患者80例纳为病例组,按年龄、孕周、孕次等匹配正常妊娠孕妇80例纳为对照组,检测两组炎症相关性指标(超敏C反应蛋白、中性粒细胞/淋巴细胞比值、红细胞分布宽度),并通过测定空腹血糖(FBG)、空腹胰岛素(FIns)计算出稳态模型胰岛素抵抗指数(HOMA-IR)。结果 GDM组的四项炎性指标即超敏C反应蛋白、白细胞计数、中性粒细胞/淋巴细胞比值、RDW均显著高于对照组,差异均具有统计学意义(t=5.695,5.232,3.337,7.814,均P<0.01)。Person相关性分析结果表明,RDW与HOMA-IR呈正相关(r=0.58,P<0.01)。结论 GDM患者RDW水平升高且与HOMA-IR呈正相关,表明炎症与GDM患者胰岛素抵抗存在一定相关性,为GDM的发病机制研究提供依据。
Abstract:
Objective To explore the relationship between the red cell volume distribution width(RDW)in patients with gestational diabetes and insulin resistance(IR).Methods A total number of 160 pregnancies performed in Guangzhou Women and Children's Medical Center fromJanuary to October 2016.Matching 80 patients with gestational diabetes(the GDM Group)with 80 healthy pregnancies according to their age,gestational weeks and times.Their inflammatory parameters(hs-CRP,neutrophil-to-lymphocyte ratio,RDW)were respectively examined.HOMA-IR was calculated by testing the levelof FBG and FIns.The association of the red cell volume distribution width withinsulin resistance was analyzed.Results The level of four inflammatory parameters(hs-CRP,WBC,neutrophil-to-lymphocyte ratio,RDW)were significantly higher than that the control group(t=5.695,5.232,3.337,7.814,all P<0.01).Pearson correlated analysis suggested that RDWhad positive correlation with HOMA-IR(r=0.58,P<0.01).Conclusion The RDW level were elevated in the GDM patients and had positive correlation with HOMA-IR,which indicated that IR was associated with inflammation and provided proof to research mechanism of GDM.

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备注/Memo

备注/Memo:
基金项目:广州市卫生局医药科技卫生项目(2016A011030)。
作者简介:高 飞(1982-),女,硕士,主管检验师,主要从事临床检验诊断学,E-mail:sunnyandantony@163.com。
通讯作者:杨红玲(1961-),女,博士,主任医师,主要从事临床检验诊断学,E-mail:hlyang62@163.com。
更新日期/Last Update: 2017-01-20