[1]朱益佳,宁明哲,杨 平,等.血清炎症性肠病抗体谱的检测对IBD诊断及鉴别诊断的临床价值[J].现代检验医学杂志,2017,32(01):141-143.[doi:10.3969/j.issn.1671-7414.2017.01.039]
　ZHU Yi-jia,NING Ming-zhe,YANG Ping,et al.Clinical Value of Diagnosis and Differential Diagnosis of Detection of Serum Inflammatory Bowel Disease Antibody Spectrum in IBD[J].Journal of Modern Laboratory Medicine,2017,32(01):141-143.[doi:10.3969/j.issn.1671-7414.2017.01.039]
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血清炎症性肠病抗体谱的检测对IBD诊断及鉴别诊断的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
141-143
栏目:
检验与临床
出版日期:
2017-01-25

文章信息/Info

Title:
Clinical Value of Diagnosis and Differential Diagnosis of Detection of Serum Inflammatory Bowel Disease Antibody Spectrum in IBD
文章编号:
1671-7414(2017)01-141-03
作者:
朱益佳; 宁明哲; 杨 平; 郑齐锶
南京大学医学院附属鼓楼医院检验科,南京 210008
Author(s):
ZHU Yi-jia; NING Ming-zhe; YANG Ping; ZHENG Qi-si
Department of Clinical Laboratory,Nanjing Drum Tower Hospital, School of Medicine,Nanjing University,Nanjing 210008,China
关键词:
炎症性肠病;  抗酿酒酵母细胞抗体;  抗中性粒细胞胞浆抗体;  抗小肠杯状细胞抗体;  抗胰腺腺泡抗体
分类号:
R574; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.01.039
文献标志码:
A
摘要:
目的 探讨抗酿酒酵母抗体(ASCA),抗胰腺腺泡抗体(PAB),抗小肠杯状细胞抗体(GAB),抗中性粒细胞胞浆抗体(ANCA)对炎症性肠病(IBD)的诊断以及溃疡性结肠炎(UC)和克罗恩病(CD)鉴别诊断的临床意义。方法 收集200例临床检测IBD抗体谱的患者血清,采用间接免疫荧光法(IF)测定。结果 200例患者血清中,106例有阳性或弱阳性指标。其中,ASCA阳性/弱阳性24例,PAB阳性/弱阳性14例,GAB阳性/弱阳性63例,ANCA阳性/弱阳性28例,并分别纳入ASCA组,PAB组,GAB组,ANCA组。ANCA和GAB诊断UC的阳性率分别为34%和58%。ASCA和PAB诊断CD的阳性率分别为28.6%和38.1%。ANCA与GAB联合检测诊断UC的特异度为60%,ASCA与PAB联合检测诊断CD的特异度为75%。结论 IBD抗体谱里ASCA,ANCA,GBA和PAB四种抗体的联合检测对IBD的诊断有重要指导价值,也可作为UC与CD的鉴别诊断方法之一。
Abstract:
Objective To investigate clinical significance of diagnosis of the anti saccharomyces cerevisiae antibody(ASCA),pancreatic acini antibody(PAB)resistance,resistance to small goblet cell antibody(GAB),anti neutrophil cytoplasm antibodies(ANCA)for inflammatory bowel disease(IBD)and the differential diagnosis of ulcerative colitis(UC)and crohn's disease(CD).Methods Collected 200 cases of test group sets of inflammatory bowel disease,serum by indirect immunofluorescence(IF).Results In the serum of 200 patients,106 cases with positive or weakly positive.Among them,the positive ASCA/weak positive 24 cases,14 cases of PAB,GAB 63 cases,28 cases ANCA,and included in ASCA group respectively and PAB group,GAB group,ANCA group.Positive rate of ANCA and GAB in the diagnosis of UC were 34% and 58%.Positive rate of ASCA and PAB in the diagnosis of CD were 28.6% and 38.1%.ANCA associated with GAB detection in the diagnosis of UC specific degree was 60%,ASCA associated with PAB detection in the diagnosis of CD specific degree was 75%.Conclusion Serum inflammatory bowel disease antibody spectrum in ASCA,ANCA,GBA and PAB four antibodies of joint detection has important guiding value to the diagnosis of IBD,also can be used as one of UC and CD in the differential diagnosis methods.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:朱益佳(1990-),女,学士,技师,主要从事临床免疫学检验工作,Tel:13770573652,E-mail:1015292337@qq.com。
更新日期/Last Update: 2017-01-20