[1]陈雪花,雷艳君.2003～2014年安康某高校新生乙肝病毒感染及免疫接种情况调查[J].现代检验医学杂志,2017,32(01):147-149,153.[doi:10.3969/j.issn.1671-7414.2017.01.041]
　CHEN Xue-hua,LEI Yan-jun.Investigation on the Freshmen' Status of the Preventive Vaccination Against Hepatitis B in A University of Ankang City in 2003～2014[J].Journal of Modern Laboratory Medicine,2017,32(01):147-149,153.[doi:10.3969/j.issn.1671-7414.2017.01.041]
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2003～2014年安康某高校新生乙肝病毒感染及免疫接种情况调查()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
147-149,153
栏目:
检验与临床
出版日期:
2017-01-25

文章信息/Info

Title:
Investigation on the Freshmen' Status of the Preventive Vaccination Against Hepatitis B in A University of Ankang City in 2003～2014
文章编号:
1671-7414(2017)01-147-04
作者:
陈雪花1; 2; 雷艳君1
1.西安交通大学医学部基础医学院,西安 710061;
2.安康职业技术学院,陕西安康 725000
Author(s):
CHEN Xue-hua1; 2; LEI Yan-jun1
1.Xi'an Jiaotong University School of Basic Medical Science,Xi'an 710061,China;
2.Ankang Vocational Technical College,Shaanxi Ankang 725000,China
关键词:
高校新生;  乙型肝炎病毒;  乙肝疫苗;  预防接种
分类号:
R512.62; R181.37
DOI:
10.3969/j.issn.1671-7414.2017.01.041
文献标志码:
A
摘要:
目的 了解安康某高校新生乙肝病毒感染率、乙肝疫苗接种后的免疫学效果,为高校乙肝防治提供科学依据。方法 以安康某高校近12年25 895例新生为调查对象,对新生乙肝病毒血清标志物五项、丙氨酸氨基转移酶的检测结果进行回顾性调查,观察接种乙肝疫苗1年后血清中HBsAb阳转率以及加强免疫后HBsAb阳转率。结果 新生乙肝表面抗原(HBsAg)阳性率4.07%,男女生阳性率分别为5.58%,3.14%,差异有统计学意义(P＜0.05)。来自农村与城镇学生乙肝表面抗原阳性率分别为4.77%,2.93%,差异有统计学意义(P＜0.05); 不同性别接种乙肝疫苗免疫效果差异无统计学意义(χ2=5.80,P＞0.05); 10 μg与5 μg乙肝疫苗免疫后血清HBsAb阳性率为95.15%,84.76%差异有统计学意义(P＜0.05)。结论 安康地区大学新生乙肝病毒感染率、乙肝保护性抗体阳性率均低于全国水平,新生乙肝病毒感染率呈现出男性高于女性、农村高于城镇的特点; 乙肝疫苗免疫效果良好,需对无应答人群加强免疫确保免疫效果。
Abstract:
Objective To understand the freshmen's statusof hepatitis B virus infection,immunological effect after vaccination against hepatitis B from a university in Ankang city,to provide a scientific basis for university's prevention from hepatitis B.Methods Analyzed the results of five markers of hepatitis B virus infection and alanine aminotransferase(ALT)of 25 895 freshmen in a college in Ankang for resent 12 years,and observed the HBsAb serocoversion in serum 1 year after vaccination against hepatitis B and after strengthened immunity.Results The HBeAg positive rate of the freshmen was 4.07%,among which the male was 5.58%(281/5 035),and the female was 3.14%(258/8 214).The difference had significance of statistic(P＜0.05).The college students'HBeAg positive rate from rural area and from urban area were 4.77% and 2.93% respectively,the differencehad significance of statistic(P＜0.05).There was no significant statistic difference in immune effect of hepatitis B vaccine for different sex(χ2=5.80,P＜0.05).Their HBsAb positive rate was 95.15% after injected with 10μg hepatitis B and 5 μg hepatitis B vaccine,which had significance of statistic(P＜0.05).Conclusion The hepatitis B virus infection rate and the hepatitis B protective antibody of the college freshmen in Ankang district was lower than that of the whole country and had a decreased tendency.It showed the male's infection rate of hepatitis B virus was higher than the female,the rural was higher than the urban,and the immune effect of hepatitis B vaccine proved to be good.It should bestrengthened immunity for non-responders to ensure the immune effect if necessary.

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备注/Memo

备注/Memo:
作者简介:陈雪花(1974-),女,本科,副主任检验技师,研究方向:免疫学,Tel:15336268797,E-mail:15336268797@163.com。
通讯作者:雷艳君(1972-),女,医学博士,硕士研究生导师,E-mail:Leiyj7268@sina.com。
更新日期/Last Update: 2017-01-20