[1]黄 允,李 艳,彭 锐,等.HBV感染致肝损伤患者CRP,hsCRP和SAA临床价值的探讨[J].现代检验医学杂志,2017,32(02):49-52.[doi:10.3969/j.issn.1671-7414.2017.02.013]
 HUANG Yun,LI Yan,PENG Rui,et al.Clinical Significance of SAA,CRP and hsCRP in HBV Hepatopathy Patients[J].Journal of Modern Laboratory Medicine,2017,32(02):49-52.[doi:10.3969/j.issn.1671-7414.2017.02.013]
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HBV感染致肝损伤患者CRP,hsCRP和SAA临床价值的探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
49-52
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Clinical Significance of SAA,CRP and hsCRP in HBV Hepatopathy Patients
文章编号:
1671-7414(2017)02-049-04
作者:
黄 允李 艳彭 锐戴 雯
武汉大学人民医院检验科,武汉 430060
Author(s):
HUANG YunLI YanPENG RuiDAI Wen
Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Wuhan 430060,China
关键词:
乙型肝炎 病毒性肝损伤 C反应蛋白 超敏C反应蛋白 血清淀粉样蛋白A
分类号:
R512.62; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.02.013
文献标志码:
A
摘要:
目的 探讨乙型肝炎病毒感染引起肝损伤的患者血清C反应蛋白(CRP)、超敏C反应蛋白(hsCRP)和血清淀粉样蛋白A(SAA)水平对肝脏受损程度的诊断价值。方法 纳入武汉大学人民医院感染科乙型肝炎病毒型肝损伤患者127例,并分组,其中临床诊断为急慢性乙型肝炎患者(轻度组)47例,乙肝后肝硬化患者(中度组)35例,慢加急性肝衰竭患者(重度组)45例。同时纳入健康体检者50例。检测上述人群血清CRP,hsCRP和SAA水平,进行统计学分析。结果 ①病例组与对照组血清CRP和hsCRP水平差异有统计学意义(Mann-Whitney U检验,Z=-2.792,-8.458; P<0.01)。②病例组间血清hsCRP水平差异有统计学意义(Kruskal-Wallis H检验,χ2=11.625,P<0.01)。③中度组和重度组血清hsCRP水平与轻度组比较,差异有统计学意义(Mann-Whitney U检验,Z=-2.849,-2.902; P<0.01)。④各组间血清SAA水平差异无统计学意义。⑤hsCRP在乙型肝炎病毒致肝损伤患者总体中阳性率为76.29%,高于CRP(11.34%),SAA(26.80%)。结论 ①乙型肝炎病毒致肝损伤患者血清CRP水平的临床价值优于SAA; ②hsCRP水平(免疫比浊法)的临床价值优于CRP(免疫荧光法)。
Abstract:
Objective To explore the diangostic value of serumhigh sensitive C-reaction prtein(hsCRP)serum amyloid a(SAA)and C-reaction protein(CRP)in patients who had HBV hepatopathy.Method 127 subjects with hepatopathy caused by HBV infection and 50 control subjects were incorporated in this research,and 47 cases with HBVhepatitis, 35 cases with HBV cirrhosis and 45 cases with hepatic failure and SAA and CRP hsCRP of every sample was detected.Results ①Levels of CRP and hsCRP in cases were significantly higher than controls(Mann-Whitney U test,Z=-2.792,-8.458,P<0.01).②The hsCRP levels in thethree different groups of cases were different(Kruskal-Wallis test,χ2=11.625,P<0.01).③The hsCRP level of group 2 and 3 was significantly higherthan group 1 in the hepatic damage groups(Mann-Whitney U test,Z=-2.849,-2.902,P<0.01).④But the level of SAA had no statistically significant in any group.⑤The seropositivity of hsCRP in cases group was 76.29% and itwas higher than CRP(11.34%)and SAA(26.80%).Conclusion The diangosic value of CRP and hsCRP may better than SAA in the patients who got HBV hepatic damage which maybe caused by detection method as hsCRP is betterthan CRP.

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备注/Memo

备注/Memo:
基金项目:国家高技术研究发展计划(863计划)子课题任务书(2014AA022304); 国家自然科学基金(81572069); 国家临床重点专科建设项目(财社[2010]305号)。
作者简介:黄 允(1992-),女,硕士,研究方向为临床检验诊断学分子诊断,E-mail:924541899@qq.com。
通讯作者:李 艳,教授,博士生导师,硕士生导师,E-mail:yanlitf1120@163.com。
更新日期/Last Update: 2017-04-10