[1]陈 文,朱旭明.血管紧张素转化酶插入/缺失基因多态性与抗高血压药疗效关系的meta分析[J].现代检验医学杂志,2017,32(02):67-71，74.[doi:10.3969/j.issn.1671-7414.2017.02.018]
　CHEN Wen,ZHU Xu-ming.Association of Polymorphism in Angiotensin Converting Enzyme Insertion/Deletion Gene with Curative Effect of Hypotensive Drugs:A Meta Analysis[J].Journal of Modern Laboratory Medicine,2017,32(02):67-71，74.[doi:10.3969/j.issn.1671-7414.2017.02.018]
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血管紧张素转化酶插入/缺失基因多态性与抗高血压药疗效关系的meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
67-71，74
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Association of Polymorphism in Angiotensin Converting Enzyme Insertion/Deletion Gene with Curative Effect of Hypotensive Drugs:A Meta Analysis
文章编号:
1671-7414(2017)02-067-06
作者:
陈 文; 朱旭明
南京医科大学附属无锡人民医院医学检验科,江苏无锡 214023
Author(s):
CHEN Wen; ZHU Xu-ming
Department of Medical Laboratory,Wuxi People's Hospital Affiliated with Nanjing Medical University,Jiangsu Wuxi 214023,China
关键词:
血管紧张素转化酶;  基因多态性;  疗效;  Meta分析
分类号:
Q786; R544.1
DOI:
10.3969/j.issn.1671-7414.2017.02.018
文献标志码:
A
摘要:
目的 评价高血压患者血管紧张素转化酶插入/缺失(ACE I/D)基因多态性与抗高血压药疗效关系。方法 检索中英文数据库论述ACE I/D与抗高血压药疗效关系的文献,根据纳入及排除标准筛选文献。采用Review Manager 5.3进行meta分析,用加权均数差(WMD)或合并优势比(OR)计算降压水平或降压有效率在DD,DI,II基因型之间的差异。结果 按检索策略共纳入包含2 528位高血压患者在内的12篇文献。全体患者在DD:II时,收缩压(SP)及舒张压(DP)下降水平的WMD分别是5.92(95%CI = 4.09～7.75)和1.70(95%CI =1.03～2.38),降压有效率OR为2.49(95%CI =1.44～4.31),差异有统计学意义(P<0.05)。按抗高血压药进行亚组分析,使用血管紧张素Ⅱ受体拮抗剂(ARB)时,SP及DP下降水平的WMD(95%CI)在DD:II分别是9.16(95%CI=6.51～11.82),1.84(95%CI=0.10～3.57),在DI:II分别是6.75(95%CI=4.21～9.28),3.38(95%CI=0.16～6.61),差异具有统计学意义(P<0.05); 使用利尿剂时,WMD不具有统计学意义。当使用血管紧张素转化酶抑制剂(ACEI)时,OR(95%CI)在DD:II及DD:DI分别是3.79(95%CI=1.80～8.01)和2.97(95%CI=1.34～6.55),差异具有统计学意义(P<0.05)。结论 相比拥有I等位基因高血压患者,ARB,ACEI等对拥有D等位基因患者降压效果更明显,但利尿剂的疗效差别不明显。
Abstract:
Objective To assess the association of polymorphism in angiotensin converting enzyme insertion/deletion(ACE I/D)gene with curative effect of hypotensive drugs.Methods The studies concerning association of ACE I/D with curative effect of hypotensive drugs were retrieved by searching data base,and then screened according to inclusive and exclusive criteria.Meta-analysis was performed by review manager 5.3 software.WMD and OR were used to assess difference of levels or effective rate of blood pressure degression among DD,DI and II genotype.Results Totally 12 articles with 2 528 patients were included in this study.For all patients,WMD(95%CI)with DD:II genotype reflecting degression level of systolicpressure(SP)and diastolic pressure(DP)were respectively 5.92(4.09～7.75)and 1.70(1.03～ 2.38),and OR(95%CI)reflecting effective rate of blood pressure degression was 2.49(1.44～ 4.31),with statistical significance(P<0.05).For subgroup analysis according to hypotensive drugs,using angiotensinⅡ receptor blocker(ARB),WMD(95%CI)of SP and DP were respectively 9.16(6.51～11.82)and 1.84(0.10～3.57)in DD:II,or 6.75(4.21～9.28)and 3.38(0.16～6.61)in DI:II genotype,all with P<0.05.There were no statistical significance for diuretic in DD:II,DD:DI and DI:II.Using angiotensin converting enzyme inhibitor(ACEI),OR(95%CI)were respectively 3.79(1.80～8.01)and 2.97(1.34～6.55)in DD:II and DD:DI,with P<0.05.Conclusion Compared with I allele in patient,ACEI and ARB were more effective for D allele,while there were no difference for curative effect of diuretic between I allele and D allele.

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备注/Memo

备注/Memo:

作者简介:陈 文(1979-),男,本科,副主任技师,主要从事临床检验研究,E-mail:340552@qq.com。
通讯作者:朱旭明(1979-),男,硕士,副主任技师,主要从事临床检验研究,E-mail:7091159@qq.com。
更新日期/Last Update: 2017-04-10