[1]杜 静,郑宝珠,夏 勇,等.复发性自然流产患者自身抗体和甲状腺功能的检测及临床意义[J].现代检验医学杂志,2017,32(02):98-101,105.[doi:10.3969/j.issn.1671-7414.2017.02.027]
 DU Jing,ZHENG Bao-zhu,XIA Yong,et al.Clinical Significance of Autoantibodies and Thyroid Function in Patients with Recurrent Spontaneous Abortion[J].Journal of Modern Laboratory Medicine,2017,32(02):98-101,105.[doi:10.3969/j.issn.1671-7414.2017.02.027]
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复发性自然流产患者自身抗体和甲状腺功能的检测及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
98-101,105
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Clinical Significance of Autoantibodies and Thyroid Function in Patients with Recurrent Spontaneous Abortion
文章编号:
1671-7414(2017)02-098-05
作者:
杜 静1郑宝珠1夏 勇1晏耀明1唐 晖1周 薇1陆 红1杨 超2
1.北京大学深圳医院检验科,广东深圳 518036;
2.深圳市人民医院外科,广东深圳 518020
Author(s):
DU Jing1ZHENG Bao-zhu1XIA Yong1YAN Yao-ming1TANG Hui1 ZHOU Wei1LU Hong1YANG Chao2
1.Department of Laboratory Medicine, Peking University Shenzhen Hospital,Guangdong Shenzhen 518036,China;
2.Department of Surgery,Shenzhen People's Hospital,Guangdong Shenzhen 518020,China
关键词:
复发性自然流产 抗核抗体 抗甲状腺抗体 甲状腺功能
分类号:
R714.21; R446.62
DOI:
10.3969/j.issn.1671-7414.2017.02.027
文献标志码:
A
摘要:
目的 分析复发性自然流产(RSA)患者血清抗核抗体(ANA)、抗甲状腺过氧化物酶抗体(TPO-Ab)、抗甲状腺球蛋白抗体(Tg-Ab)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)的检测结果及临床意义。方法 选取2015年3~12月北京大学深圳医院妇产科门诊确诊为RSA的患者46例为疾病组,健康对照(health control,HC)组选择同期无任何不良孕产史的20例女性,采用间接免疫荧光法(IIF)和ELISA方法检测46例RSA患者和50例正常对照血清ANA,采用化学发光法检测TPO-Ab,Tg-Ab,TSH,FT3,FT4。结果 RSA组和对照组血清ANA(IIF),TPO-Ab,Tg-Ab阳性率分别是24%,24%,15%和15%,5%,5%,二者差异有统计学意义(P<0.05)。RSA组和对照组血清TSH,TPO-Ab,Tg-Ab水平分别是2.70±1.38 mIU/L,38.99±10.18 IU/ml,3.07±1.69 IU/ml和2.14±1.32 mIU/L,4.04±1.32IU/ml,0.64±0.53 IU/ml,二者差异有统计学意义(P<0.05)。结论 ANA和甲状腺抗体阳性可能和RSA发生相关,检测两者水平对于寻找不孕原因及采取适宜干预措施具有重要意义。
Abstract:
Objective To study the clinical significance of antinuclear antibody(ANA),anti-thyroid peroxidase antibody(TPO-Ab)and antithyroglobulin antibody(Tg-Ab),thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)in patients with recurrent spontaneousabortion(RSA).Methods 46 women with RSA diagnosis in out-patient department in Peking University Shenzhen Hospital from March 2015 toDecember 2016 were recruited as the study group,20 women with normal childbirthhistory were enrolled as the control group,ANA was detected by indirect immunofluorescence(IIF)assay and ELISA,TSH,FT3 and FT4 were detected by chemiluminescence immunoassay technology.Results The positive rates of ANA(IIF),TPO-Ab and Tg-Ab in patients with RSA were 24%,24% and 15% respectively which were significantly higher than those in healthy control(P<0.05).Serum levels of TSH,TPO-Ab and Tg-Ab in patients with RSA were 2.70±1.38 mIU/L,38.99±10.18 IU/ml and 3.07±1.69 IU/ml respectively,which were significantly higher than those in healthy cases(P<0.05).Conclusion ANA and antithyroid antibodies were closely related with RSA.It is very important to screen ANA and antithyroid antibodies for etiological diagnosis and appropriate intervention in patients with RSA to reduce the incidence of abortion.

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备注/Memo

备注/Memo:

作者简介:杜 静(1971-),女,博士,主任技师,从事临床免疫检验工作,主要研究方向:自身免疫性疾病研究,Tel:0755-83923333-2286,E-mail:dujing83@hotmail.com。
通讯作者:杨 超,男,博士,主任医师,从事心血管方面研究,Tel:0755-25533018,E-mail:tschaoyang@gmail.com。
更新日期/Last Update: 2017-04-10