[1]袁学华,张薇薇,李权伦,等.血清视黄醇结合蛋白、胱抑素C及β2微球蛋白的联合检测在妊娠期糖尿病早期肾损害诊断中的临床意义[J].现代检验医学杂志,2017,32(02):106-109.[doi:10.3969/j.issn.1671-7414.2017.02.029]
　YUAN Xue-hua,ZHANG Wei-wei,LI Quan-lun,et al.Clinical Significance of Combined Detection of Serum Retinal-binding Protein,Cystatin C and β2-micoglobuimin in Diagnosis of Early Renal Injures of Gestational Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2017,32(02):106-109.[doi:10.3969/j.issn.1671-7414.2017.02.029]
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血清视黄醇结合蛋白、胱抑素C及β2微球蛋白的联合检测在妊娠期糖尿病早期肾损害诊断中的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
106-109
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Clinical Significance of Combined Detection of Serum Retinal-binding Protein,Cystatin C and β2-micoglobuimin in Diagnosis of Early Renal Injures of Gestational Diabetes Mellitus
文章编号:
1671-7414(2017)02-106-04
作者:
袁学华1; 张薇薇2; 李权伦1; 柯盈月1; 王字卉1
1.十堰市妇幼保健院检验科,湖北十堰 442000;
2.湖北医药学院附属人民医院感染性疾病科,湖北十堰 442000
Author(s):
YUAN Xue-hua1; ZHANG Wei-wei2; LI Quan-lun1; KE Ying-yue1; WANG Zi-hui1
1.Department of Clinical Laboratory,Shiyan Maternal and ChildHealth Care Hospital, Hubei Shiyan 442000,China;
2.Department of Infectious Disease,Affiliated Renmin Hospital of Hubei University of Medicine,Hubei Shiyan 442000,China
关键词:
视黄醇结合蛋白;  半胱氨酸蛋白酶抑制剂C;  β2微球蛋白;  妊娠期糖尿病;  早期肾脏损伤
分类号:
R714.256; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.02.029
文献标志码:
A
摘要:
目的 探讨血清视黄醇结合蛋白(RBP)、胱抑素C(Cys C)及β2微球蛋白(β2-M)联合检测在妊娠期糖尿病(GDM)早期肾损害的诊断价值。方法 选取2009年1月～2015年1月在十堰市妇幼保健院患妊娠期糖尿病待产妇患者85例,根据其尿清蛋白排泄率(UAER)的测定结果被分为单纯糖尿病组(35例)、微量蛋白尿组(30例)和大量蛋白尿组(20例),选取同期来院待产的健康孕妇30例为正常对照组,比较4组间24 h尿蛋白量,血清RBP和肾功能指标[尿素氮(BUN),肌酐(Scr),Cys C和β2-M]水平,血清RBP,Cys C,β2-M单项及3项指标联合检测的阳性率。结果 单纯糖尿病组,微量蛋白尿组及大量蛋白尿组的24 h尿蛋白量均明显高于对照组(t=3.91～16.33,均P<0.01),且3组间两两比较,差异均有统计学意义(t=6.78～16.94,均P<0.01); 微量蛋白尿组和大量蛋白尿组的BUN,Scr,CysC,β2-M,RBP水平均明显高于对照组和单纯糖尿病组(t=3.68～18.54,均P<0.01),微量蛋白尿组与大量蛋白尿组间上述指标差异均有统计学意义(t=4.70～10.87,均P<0.01); 微量蛋白尿组和大量蛋白尿组血清RBP,Cys C,β2-M单项及3项指标联合检测阳性率明显高于对照组和单纯糖尿病组(χ2=20.27～38.57,均P<0.01),微量蛋白尿组与大量蛋白尿组间上述指标阳性率差异无统计学意义(χ2=0.62～0.93,均P>0.05); 同组3项指标的联合检测阳性率高于单项检测的阳性率(χ2=3.97～6.65,P<0.05或P<0.01)。结论 血清RBP,Cys C及β2-M的检测对妊娠期糖尿病早期肾损害诊断有较高的临床价值,3项指标联合检测的阳性率高于单项指标。
Abstract:
Objective To study the diagnosis value of serumretinol binding protein(RBP),cystatin C(Cys C)and β2 microglobulin(β2-M)in early renal injures of gestational diabetes mellitus(GDM)patients.Methods 85 case of GDM pregnant women admitted to Shiyan Maternal and Child Health-Care Hospital from Jan.2009 to Jan 2015 were chosen as research objects,and were divided into simple diabetes group(35 cases),micro proteinuria group(30 cases)and massive proteinuria group(20 cases)according tothe urinary albumin excretion rate(UAER),while 30 cases of healthy pregnant women were recruited randomly during the same period as control group.The 24h urine protein,serum RBP and renal function indicators [blood urea nitrogen(BUN),creatinine(Scr),Cys C and β2-M],the positive rates of RBP,Cys C,β2-Mand combined detection of RBP,Cys C,β2-M of the four groups were compared.Results The 24h urine protein in simple diabetes group,micro proteinuria group and massive proteinuria group were significantly higher than that in the control group(t=3.91～16.33,all P<0.01),the difference between the 3 groups were statistically significant(t=6.78～16.94,all P<0.01).The levels of BUN,Scr,Cys C,β2-M and RBP in micro proteinuria group and massive proteinuria group were significantly higher than those incontrol group and simple diabetic group(t=3.68～18.54,all P<0.01),there were significant difference in above indexes between micro proteinurine group and massive proteinuria group(t=4.70～10.87,all P<0.01).The positive rates of RBP,Cys C,β2-M and combined detection of RBP,Cys C and β2-M in micro proteinuria group and massive proteinuria group were significantlyhigher than those in control group and simple diabetic group(χ2=20.27～38.57,all P<0.01).There was no significant difference in the positive rates between micro proteinuria group and massive proteinuria group(χ2=0.62～0.93,all P>0.05).The positive rate of combined detection of the three indicators was higher than that of the single detection in the same group(χ2=3.97～6.65,P<0.05 or P<0.01).Conclusion The detection of serum Cys C,RBP and β2-M has a high clinical value in thediagnosis of early renal damage in patients with GDM.The positive rate of combined detection of 3 indexes was higher than that of single index.

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备注/Memo

备注/Memo:

作者简介:袁学华(1968-),男,本科,副主任技师,从事临床检验工作,Tel:13635711220,E-mail:syyuanxh@sina.cn。
通讯作者:张薇薇(1969-),女,本科,从事感染性疾病临床和教学工作,Tel:13635711220,E-mail:syzhangww@sina.com。
更新日期/Last Update: 2017-04-10