[1]朱 娜a,张利侠b,张 华b,等.血清四项生化指标联合检测在狼疮肾炎患者早期肾损伤的临床意义[J].现代检验医学杂志,2017,32(02):114-116.[doi:10.3969/j.issn.1671-7414.2017.02.031]
　ZHU Naa,ZHANG Li-xiab,ZHANG Huab,et al.Clinical Significance of Serum Bun,Cr,Cys C and RBP Combined Detection for Early Diagnosis of Renal Damage in Patlents with Lupus Nephritis[J].Journal of Modern Laboratory Medicine,2017,32(02):114-116.[doi:10.3969/j.issn.1671-7414.2017.02.031]
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血清四项生化指标联合检测在狼疮肾炎患者早期肾损伤的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
114-116
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Clinical Significance of Serum Bun,Cr,Cys C and RBP Combined Detection for Early Diagnosis of Renal Damage in Patlents with Lupus Nephritis
文章编号:
1671-7414(2017)02-114-03
作者:
朱 娜a; 张利侠b; 张 华b; 奚逢瑜b; 冯 婷c
陕西省人民医院a.科研处; b.检验科; c.肾内科,西安 710068
Author(s):
ZHU Naa; ZHANG Li-xiab; ZHANG Huab; XI Feng-yub; FENG Tingc
a.Scientific Research Division; b.Department of Clinical Laboratory; c.Renal Department of Nephrology, Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
狼疮肾炎;  尿素氮;  肌酐;  胱抑素C;  视黄醇结合蛋白;  联合检测
分类号:
R593.242; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.02.031
文献标志码:
A
摘要:
目的 探讨血清尿素氮(BUN)、肌酐(Cr)、胱抑素C(CysC)和视黄醇结合蛋白(RBP)四项生化指标联合检测对狼疮肾炎(LN)的早期诊断价值。方法 选择2011年1月～2016年4月陕西省人民医院收治并符合美国风湿病协会(ACR)2012年修订的SLE诊断标准并伴有肾脏病变的177例LN患者,同时选择167例健康体检者作为对照组。采用日立7170A全自动生化分析仪对两组血清BUN,Cr,CysC和RBP浓度进行检测,所得数据用SPSS17.0统计软件进行统计分析。结果 LN患者组与健康对照组比较,血清BUN(6.67±1.43 mmol/L vs 6.57±1.16 mmol/L),Cr(96.9±10.1μmol/L vs 92.6±13.2 μmol/L),CysC(1.7±0.5 mg/L vs 0.75±0.15 mg/L),RBP(180.5±8.28 mg/L vs 42.6±9.6 mg/L)浓度均升高,且血清CysC,RBP升高水平与健康对照组比较差异有统计学意义(t=8.145,21.594,均P<0.05)。单项指标检测异常率方面,LN患者组血清BUN,Cr,CysC和RBP的异常率分别为28.3%,29.4%,68.4%和65.0%。四项指标联合检测异常率为85.3%,明显高于单项指标检测异常率(χ2=35.973～168.742,P<0.01)。结论 血清BUN,Cr,CysC和RBP四项生化指标联合检测对LN患者肾损伤的早期诊断具有重要意义。
Abstract:
Objective To research the serum urea nitrogen(BUN),creatinine(Cr),urinary inhibition C(CysC)and retinol binding protein(RBP)four biochemical indicators of joint detection on the early diagnostic value of lupus nephritis(LN).Methods According to the American Rheumatology Association(ACR)2012 revision of the diagnostic criteria,collected 177 LN patients with kidney disease from January 2011 to April 2016 in Shaanxi Provincial People's Hospital,at the same time,choose 167 cases of healthy physical examination as normal control group.With Hitachi 7170A a fully automated analyzer on two groups of serum BUN,Cr,CysC and concentration of RBP fortesting,the data obtained by SPSS17.0 statistical software for statistical analysis.Results LN patient group compared with healthy controls,the serum BUN(6.67±1.43 mmol/L vs 6.57±1.16 mmol/L),Cr(96.9±10.1 μmol/L vs 92.6±13.2 μmol/L),CysC(1.7±0.5 mg/L vs 0.75±0.15 mg/L),RBP(180.5±8.28 mg/L vs 42.6±9.6 mg/L)concentrations were higher,andserum CysC,RBP higher level compared with healthy control group difference wasstatistically significant(t=8.145,21.594,all P<0.05).Single parameter detected abnormal rate in terms of LN patients serum BUN,Cr,CysC and RBPabnormal rates were 28.3%,29.4%,68.4%,65.0%,four indicators combined detection of abnormal rate was 85.3%,significantly higher than the single parameter test(χ2=35.973～168.742,all P<0.01).ConclusionConbined detection of BUN,Cr,CysC and RBP four early diagnosis of renal damage in patients with lupus nephritis had important clinical value.

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备注/Memo

备注/Memo:
基金项目:西安市科技局科学发展计划项目,编号2016046SF/YX02(3)。
作者简介:朱 娜(1982-),女,硕士,主治医师,研究方向:免疫学检验与肾脏病研究,Tel:18629315799,E-mail:happybabyegg@163.com。
通讯作者:冯 婷(1982-),女,硕士,主治医师,研究方向:自身免疫性肾脏疾病的诊断研究,Tel:13619246730,E-mail:31516879@qq.com。
更新日期/Last Update: 2017-04-10