[1]文关良,剌 梅.脂蛋白相关磷脂酶A2在颈动脉斑块性脑梗死中的临床意义[J].现代检验医学杂志,2017,32(02):117-118，122.[doi:10.3969/j.issn.1671-7414.2017.02.032]
　WEN Guan-liang,LA Mei.Clinical Study of LP-PLA2 in Carotid Plaques Cerebral Infarction Patients[J].Journal of Modern Laboratory Medicine,2017,32(02):117-118，122.[doi:10.3969/j.issn.1671-7414.2017.02.032]
点击复制

脂蛋白相关磷脂酶A2在颈动脉斑块性脑梗死中的临床意义()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
117-118，122
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Clinical Study of LP-PLA2 in Carotid Plaques Cerebral Infarction Patients
文章编号:
1671-7414(2017)02-117-03
作者:
文关良; 剌 梅
乾县中医医院检验科，陕西乾县 713300
Author(s):
WEN Guan-liang; LA Mei
Department of Clinic al Laboratory， Chinese Traditional Medicine Hospital of Qian County，Shaanxi Qianxian 713 300，China
关键词:
颈动脉斑块; 脑梗死; 脂蛋白相关磷脂酶A2; 斑块稳定性
分类号:
R743.33；R446.11
DOI:
10.3969/j.issn.1671-7414.2017.02.032
文献标志码:
A
摘要:
目的 探讨脂蛋白相关磷脂酶A2(LP-PLA2)与颈动脉斑块性 脑梗死的相关性及其对颈动脉斑块稳定性的预测价值。 方法 按照颈动脉彩色多普勒超声检查结果，将169例脑梗死患者分为颈动脉斑块性脑梗死 组101例和非颈动脉斑块性脑梗死组68例，根据斑块性质将颈动脉斑块性脑梗死组分为稳定 性斑块组30例和不稳定性斑块组71例，同时设立健康对照组，采用双抗体夹心酶联免疫吸附 法(ELISA)检测并比较各组LP-PLA2水平，通过绘制受试者工作特征(ROC)曲线评估其对颈动 脉斑块稳定的预测价值。结果 颈动脉斑块组LP-PLA2水平(212.90 ±117.69 ng/ml)明显高于无斑块组(127.70±57.96 ng/ml；t=3.016，P<0.01)； 无斑块组与健康对照组(108.34±42.58 ng/ml)无明显差异(t=0.779，P>0.05)；不 稳定性斑块组(236.24±128.33　ng/ml)明显高于稳定性斑块组(157.65±59.27 ng/ml ；t=3.442，P<0.01)。结论 血浆LP-PLA2水平与颈动脉斑块 性脑梗死有一定相关性，可作为脑梗死鉴别和评估颈动脉斑块稳定性的较好指标。
Abstract:
Objective To study the relationship between the lipoprotein associated phospholipase A2 (LP-PLA2) with the carotid plaques cer ebral infarction，and study the predictive value of LP-PLA2 in carotid artery p laque stability．Methods According to the results of colo r doppler ultrasound examination of carotid artery，169 patients with cerebral i nfarction were random divided into cerebral infarction with carotid plaques grou p(101 patients) and cerebral infarction without carotid plaques group(68 patient s) groups．According to the nature of plaque stability of carotid plaques．101 c ases of cerebral infarction with carotid plaques group was divided into plaques group 30 cases and 71 cases of unstable plaque group．Set healthy control groups at the same time．Then detected level of LP-PLA2 for each patient by the metho d of double antibody sandwich enzyme-linked immunosorbent (ELISA)．To evaluate the predictive value of LP-PLA2 in carotid artery plaque stability by mapping t he receiver-operating characteristic (ROC) curve．Results The level of LP-PLA2 (212.90±117.69 ng/ml) in carotid plaques group were s ignificantly higher than those without plaque group (127.70±57.96 ng/ml，t= 3.016，P<0.01)．It was not show significantly difference between　no plaque group and healthy control group (108.34 ± 42.58 ng/ml，t=0.779，P>0.05) ．But it showed significantly different between the unstable plaque group (236. 24±128.33 ng/ml) and stability plaques group (157.65±59.27 ng/ml，t=3.44 2，P<0.01)．Conclusion The LP-PLA2 of plasma could be involved in the development of atherosclerosis plaques．The LP -PLA2 can certa in correlation with cerebral infarction of carotid plaques，can well evaluate th e stability of carotid plaques．

参考文献/References:

[1] Kazmierski MK.Stenosis of the carotid arteries[J].Wiad Lek,2003,56(5/6):260-265.
[2] Epps KC,Wilensky RL.Lp-PLA2-a novel risk factor for high-risk coronary and carotid artery disease[J].J Intern Med,2011,269(1):94-106.
[3] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146-153. Neurology branch of cerebrovascular disease diagnosis and treatmentof acute ischemic stroke group guidelines writing group of Chinese Medical Assocration.Guide for diagnosis and treatment of acute ischemic stroke in China 2010[J].Chinese Jounal Neurology,2010,43(2):146-153.
[4] Lavi S,Herrman J,Lavi R,et al.Role of lipoprotein-associated phospholipase A2 in atherosclerosis[J].Curr Atheroscler Rep,2008,10(3):230-235.
[5] 王 磊,储照虎.脂蛋白相关磷脂酶A2与缺血性卒中[J].国际脑血管病杂志,2009,17(6):463-466. Wang L,Chu ZH.Lipoprotein-associated phospholipase A2 and ischemic stroke[J].International Journal of Cerebrovascular Disease,2009,17(6):463-466.
[6] 徐冬玲,刘军妮,杜贻萌,等.脂蛋白相关磷脂酶与冠状动脉易损斑块的相关性[J].中华内科杂志,2009,48(8):651-654. Xu DL,Liu JN,Du YM,et al.Correlation of haman serum LP-PLA2 and hs-EPR and stability of coronary atherosclerotic plaques[J].Chinese Journal Intern Medical,2009,48(8):651-654.
[7] 李青芳,梁江红,邓胜玲.脂蛋白相关磷脂酶A2与脑梗死患者颈动脉不稳定粥样斑块的关系[J].实用医学杂志,2009,25(2):224-226. Li QF,Liang JH,Deng SL.Relationship between LP-PLA2 and carotidatherosderotic plaque in patients with cerebral infaction[J].Journal of Practical Medicine,2009,25(2):224-226.
[8] 钟 萍,吴丹红,吴计划,等.血清脂蛋白相关磷脂酶A2和超敏C-反应蛋白水平与大动脉粥样硬化性脑梗死关系的临床研究[J].中华临床医师杂志(电子版),2012,6(4):924-927. Zhong P,Wu DH,Wu JH,et al.The roles of LP-PLA2 and hs-CRP levels in large artery atherosclerosis ischemic stroke[J].Chinese Journal of Clinicains(Electronic Edition),2012,6(4):924-927.

相似文献/References:

[1]王兴宁,李 慧,米思蓉,等.脑梗死患者血清同型半胱氨酸水平与颈动脉粥样硬化的相关性研究[J].现代检验医学杂志,2015,30(03):46.[doi:10.3969/j.issn.1671-7414.2015.03.013]
　WANG Xing-ning,LI Hui,MI Si-rong,et al.Analysis of Relationship between Homocysteine and Carotid Atherosclerosis in Patients with Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2015,30(02):46.[doi:10.3969/j.issn.1671-7414.2015.03.013]
[2]张瑞.脑梗死患者血清同型半胱氨酸、血浆叶酸和维生素B12水平的相关性研究[J].现代检验医学杂志,2015,30(05):118.[doi:10.3969/j.issn.1671-7414.2015.05.036]
　ZHANG Rui.Correlation Study on Homocysteine，Plasma Folate and Vitamin B12 Levels in Serum of Cerebral Infarction Patients[J].Journal of Modern Laboratory Medicine,2015,30(02):118.[doi:10.3969/j.issn.1671-7414.2015.05.036]
[3]程俊杰,李 静,梁西强,等.高血压并发脑梗死患者不同血脂分层下病死率的分析研究[J].现代检验医学杂志,2017,32(03):97.[doi:10.3969/j.issn.1671-7414.2017.03.026]
　CHENG Jun-jie,LI Jing,LIANG Xi-qiang,et al.Significance on Cerebral Infarction’s Fatality Rate for the Retrospective Analysis of Hypertension under Serum Lipids Layer Management[J].Journal of Modern Laboratory Medicine,2017,32(02):97.[doi:10.3969/j.issn.1671-7414.2017.03.026]
[4]屈山脉,郭进京.脑梗死与脑出血患者相关生化指标水平差异及临床意义[J].现代检验医学杂志,2018,33(02):114.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　QU Shan-mai,GUO Jin-jing.Clinical Significance and Difference of Some Biochemical Indexes in Patients with Cerebral Infarction and Cerebral Hemorrhage[J].Journal of Modern Laboratory Medicine,2018,33(02):114.[doi:10.3969/j.issn.1671-7414.2018.02.001]
[5]韩　光.外周血血小板参数对评估急性脑梗死患者生活能力改善的临床价值[J].现代检验医学杂志,2020,35(02):119.[doi:10.3969 ／ j.issn.1671-7414.2020.02.033]
　HAN Guang.Clinical Value of Platelet Parameters in Evaluating the Improvement of LifeAbility in Patients with Acute Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2020,35(02):119.[doi:10.3969 ／ j.issn.1671-7414.2020.02.033]
[6]张　盼,薛　伟a,张　熊b,等.急性脑缺血患者血清IGFBP-4和PLGF水平与颈动脉斑块不稳定性的相关性研究[J].现代检验医学杂志,2021,36(05):124.[doi:10.3969/j.issn.1671-7414.2021.05.028]
　ZHANG Pan,XUE Weia,ZHANG Xiongb,et al.Correlation between the Levels of IGFBP-4, PlGF in Serum and CarotidPlaque Instability in Patients with Acute Cerebral Ischemia[J].Journal of Modern Laboratory Medicine,2021,36(02):124.[doi:10.3969/j.issn.1671-7414.2021.05.028]
[7]王国玲,张博刚,郭 娟,等.脑梗死患者血清miR-181d和miR-210水平表达与颈动脉狭窄程度及预后的相关性研究[J].现代检验医学杂志,2021,36(06):64.[doi:10.3969/j.issn.1671-7414.2021.06.013]
　WANG Guo-ling,ZHANG Bo-gang,GUO Juan,et al.Correlation between Serum miR-181d and miR-210 Levels in Patients with Cerebral Infarction and the Degree of Carotid Artery Stenosis and Prognosis[J].Journal of Modern Laboratory Medicine,2021,36(02):64.[doi:10.3969/j.issn.1671-7414.2021.06.013]
[8]欧鲤娴,孙清己,侯俊霞,等.脑梗死患者血清sdLDL，GSH-Px，Hcy及SDF-1水平与血管狭窄的相关性研究[J].现代检验医学杂志,2021,36(06):83.[doi:10.3969/j.issn.1671-7414.2021.06.017]
　OU Li-xian,Sun Qing-ji,HOU Jun-xia,et al.Study on the Correlation between Serum sdLDL, GSH-Px, Hcy and SDF-1 Levels and Vascular Stenosis in Patients with Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2021,36(02):83.[doi:10.3969/j.issn.1671-7414.2021.06.017]

备注/Memo

备注/Memo:

作者简介:文关良(1978-)，男，本科学历，主管检验师，研究方向：生化与免疫，Tel：15309102577，E-mail：wenliang77@sohu.com。
更新日期/Last Update: 2017-04-10