[1]乔国昱,何亚萍,周 洁.妊娠期糖尿病并发甲状腺功能减退孕妇凝血功能指标的变化研究[J].现代检验医学杂志,2017,32(03):109-111.[doi:10.3969/j.issn.1671-7414.2017.03.029]
　QIAO Guo-yu,HE Ya-ping,ZHOU Jie.Study on the Alteration of Blood Coagulation Function of PregnantWomen with Pothyroidism Companied with Gestational Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2017,32(03):109-111.[doi:10.3969/j.issn.1671-7414.2017.03.029]
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妊娠期糖尿病并发甲状腺功能减退孕妇凝血功能指标的变化研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
109-111
栏目:
论著
出版日期:
2017-05-25

文章信息/Info

Title:
Study on the Alteration of Blood Coagulation Function of Pregnant Women with Pothyroidism Companied with Gestational Diabetes Mellitus
文章编号:
1671 -7414(2017)03-109-03
作者:
乔国昱1; 何亚萍2; 周 洁1
1.唐山市协和医院检验科，河北唐山 063000；
2.唐山市妇幼保健院检 验科，河北唐山 063000
Author(s):
QIAO Guo-yu1; HE Ya-ping2; ZHOU Jie1
1.Department of Clinical Laboratory， Xiehe Hospital of Tangshan City，Hebei Tangshan 063000，China；
2.Departme nt of Clinical Laboratory，Tangshan Female and Child Health Hospital，Hebei Tang shan 063000，China
关键词:
甲状腺功能减退; 亚临床甲状腺功能减退; 妊娠期糖尿病; 凝 血; 血小板
分类号:
R714.256；R446.112
DOI:
10.3969/j.issn.1671-7414.2017.03.029
文献标志码:
A
摘要:
目的 探讨妊娠期糖尿病并发甲状腺功能减退孕妇凝血功能 指标的变化及意义。方法 选取2014年9月～2016年3月在唐山市协和 医院妇产科检查的妊娠期糖尿病并发甲状腺功能减退孕妇76例为观察组，根据FT3，FT4，TS H水平将观察组分为A组36例(妊娠期糖尿病并发甲减)，B组40例(妊娠期糖尿病并发亚临床甲 减)，另选同期妊娠期糖尿病孕妇40例为对照组。采用化学发光分析仪测定各组促甲状腺素( TSH)，游离三碘甲状原氨酸(FT3)和游离甲状腺素(FT4)；贝克曼ACL-TOP全自动血凝仪检测 凝血酶原时间(PT)，活化部分凝血活酶时间(APTT)，凝血酶时间(TT)，纤维蛋白原(FIB)和 抗凝血酶Ⅲ(ATⅢ)；Sysmex2000i全自动血细胞分析仪检测血小板计数(PLT)，血小板平均体 积(MPV)和血小板分布宽度(PDW)。单因素方差分析和LSD检验进行分析。结果 A组FIB(3.98±1.74 g/L)，MPV(10.18±1.53 fl)，PDW(15.03%±1.54％) 高于B组(3.91±1.62 g/L，9.37±1.48 fl，14.41%±1.35％)和对照组(3.47±1.4 3 g/L，8.96±1.42 fl，13.67%±1.26％)，B组FIB，MPV，PDW高于对照组；A组和B组P T(12.26±1.41s，12.21±1.39s)，APTT(31.80±8.72s，30.43±8.54s)高于对照 组(12.13±1.32s，29.24±8.37s)，而ATⅢ(78.47%±10.36%，79.58%±10.22%)低 于对照组(86.56%±8.86%)，差异均有统计学意义(t=3.072～6.153，P值均<0.05) 。结论 妊娠期糖尿病并发甲状腺功能减退孕妇存在凝血功能紊乱， 对其进行早期诊断与干预，可降低血栓性疾病和心血管疾病的发生。
Abstract:
Objective To investigate the changes and the si gnificances of pregnant women with hypothyroidism companied with gestational dia betes mellitus．Methods 76 cases of hypothyroidism and su bclinical hypothyroidism companied with gestational diabetes mellitus pregnant w omen admitted to our department from Sept 2014 to Mar 2016 were selected as the observation group．According to the levels of FT3，FT4 and TSH，the observation group were divided into two group(A group and B group)．Cobas e601 was used to e xamine TSH and PT，APTT，TT，FIB and ATⅢ were determined with ACL-TOP．PLT，MP V and PDW were determined by Sysmex2000i．Results FIB (3 .98±1.74 g/L)，MPV (10.18±1.53 fl)and PDW (15.03%±1.54％)in A group wer e significant higher than those in B group (3.91±1.62 g/L，9.37±1.48 fl，1 4.41%±1.35％) and the control group (3.47±1.43 g/L，8.96±1.42 fl，13.6 7%±1.26％)．FIB，MPV and PDW in B group was higher than those in the control g roup．PT (12.26±1.41 s，12.21±1.39 s) and APTT (31.80±8.72 s，30.43±8 .54 s) in A group and Bgroup were higher than those in the control group (12.1 3±1.32 s，29.24±8.37 s)．Otherwise，ATⅢ (78.47%±10.36%，79.58%±10.22 %) in A group and B group was significant lower than that in the control group ( 86.56%±8.86%)．There were distinct difference (t=3.072～6.153，P<0.05) ．Conclusion The disorder of blood coagulation existed in pregnant women with hypothyroidism companied with gestational diabetes mellitus ．Early diagnosis and intervention can reduce the occurrence of thrombotic disea se and cardiovascular disease．

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备注/Memo

备注/Memo:

作者简介：乔国昱(1973-)，男，硕士研究生，主任技师，研究方 向：临床免疫学、分子生物学，Tel：18032552212，E-mail：qiaoguoyu1973@sina.com。
更新日期/Last Update: 2017-06-25