[1]王方平,张平安,杨晓燕.高迁移率蛋白B1介导Toll样受体信号通路的研究进展[J].现代检验医学杂志,2017,32(03):162-164.[doi:10.3969/j.issn.1671-7414.2017.03.045]
WANG Fang-ping,ZHANG Ping-an,YANG Xiao-yan.Updates on the Pathways of Toll-Like Receptors Mediated by HMGB1[J].Journal of Modern Laboratory Medicine,2017,32(03):162-164.[doi:10.3969/j.issn.1671-7414.2017.03.045]
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高迁移率蛋白B1介导Toll样受体信号通路的研究进展(
)
《现代检验医学杂志》[ISSN:/CN:]
- 卷:
-
第32卷
- 期数:
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2017年03期
- 页码:
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162-164
- 栏目:
-
综述
- 出版日期:
-
2017-05-25
文章信息/Info
- Title:
-
Updates on the Pathways of Toll-Like Receptors Mediated by HMGB1
- 文章编号:
-
1671-7414(2017)0
- 作者:
-
王方平; 张平安; 杨晓燕
-
武汉大学人民医院检验科，
武汉 430060
- Author(s):
-
WANG Fang-ping; ZHANG Ping-an; YANG Xiao-yan
-
Department of Medical Laboratory，Renmin Hospital of Wuhan Unive
rsity，Wuhan 430060，China
-
- 关键词:
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高迁移率蛋白B1; Toll样受体; 信号通路
- 分类号:
-
R392.1
- DOI:
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10.3969/j.issn.1671-7414.2017.03.045
- 文献标志码:
-
A
- 摘要:
-
高迁移率族蛋白B1(high mobility group box 1 protein
，HMGB1)是核内一类非组蛋白DNA结合蛋白，属于损伤相关分子模式(damage-associated m
olecular patterns，DAMPs)，参与DNA复制、重组、修复和基因转录调控等。HMGB1能通
过Toll样受体(Toll-like receptor，TLR)等激活固有免疫以及诱导T细胞分化成熟启动适
应性免疫应答，与多种自身免疫性疾病、炎症性疾病和肿瘤等关系密切。目前关于HMGB1介
导TLR信号通路在某些疾病中的作用的研究较多，HMGB1介导Toll样受体信号通路参与多种病
理过程具有广阔的临床前景。
- Abstract:
-
High mobility group box 1 protein，a kind of dam
age-associated molecular patterns，is a group of nonhistone DNA-binding prote
in in the nuclear．It not only involves in DNA replication，recombination，repai
r，regulation of gene transcription，but also induces activation of innate immun
ity and T cell generation and activates the adaptive immune response through Tol
l-like receptor．It is also more closely related to autoimmune diseases，inflam
matory diseases，tumors and so on．Currently there are many researches on the ro
le of TLR-mediated HMGB1 signaling pathway in diseases，which is involved in a
variety of pathological processes and has a broad clinical outlook．
参考文献/References:
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oup box 1 in the development and maintenance of chemotherapy-induced peripheral
neuropathy in rats［J］．Toxicology，2016(365)：48-58．
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011，31(5)：1024-1032．
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．
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备注/Memo
- 备注/Memo:
-
作者简介：
王方平(1989-)，女，硕士研究生在读，医师，主要从事临床感染及
免疫学研究，Tel：15927445873，E-mail：2872257649@qq.com。
通讯作者：张平安，E-mail：zhangpingan@aliyun.com。
更新日期/Last Update:
2017-06-25