[1]宋令雄,张 燕,张明威,等.儿童原发性肾病综合征患者血清补体C1q水平变化及其临床意义[J].现代检验医学杂志,2017,32(04):1-5.[doi:10.3969/j.issn.1671-7414.2017.04.001]
　SONG Ling-xiong,ZHANG Yan,ZHANG Ming-wei,et al.Study on Serum Levels of C1q and Their Clinical Significance in Children with Nephrotic Syndrome[J].Journal of Modern Laboratory Medicine,2017,32(04):1-5.[doi:10.3969/j.issn.1671-7414.2017.04.001]
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儿童原发性肾病综合征患者血清补体C1q水平变化及其临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
1-5
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Study on Serum Levels of C1q and Their Clinical Significance in Children with Nephrotic Syndrome
文章编号:
1671-7414(2017)04-001-05
作者:
宋令雄; 张 燕; 张明威; 印中鹏; 宇世飞; 汪俊军; 宋佳希
南京大学医学院附属金陵医院临床检验科
Author(s):
SONG Ling-xiong; ZHANG Yan; ZHANG Ming-wei; YIN Zhong-peng; YU Shi-fei;  WANG Jun-jun; SONG Jia-xi
Department of Clinical Laboratory, Jinling Hospital Affiliated to Medical College of Nanjing University,State Key Clinical Department,Institute of Clinical Laboratory Medicine,Nanjing 210002,China
关键词:
血清C1q;  儿童肾病综合征;  血脂;  三酰甘油
分类号:
R692; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.04.001
文献标志码:
A
摘要:
目的 分析原发性肾病综合征(PNS)患儿血清补体C1q水平的变化,探讨急性期和恢复期NS患儿血清补体C1q水平的差异及其与其他生化指标的相关性。方法 收集2016年3月～10月在南京大学医学院附属金陵医院肾内科住院并确诊的儿童PNS患者标本141例,其中急性期NS患儿78例、恢复期NS患儿63例。分别检测NS患儿和健康对照儿童(77例)的血清补体C1q水平,同时测定其血清总蛋白(TP)、清蛋白(ALB)、血脂[包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及肾功能指标[尿素(Urea)、肌酐(Cr)、尿酸(Uric)]水平,并进行统计学分析。结果 急性期NS组血清补体C1q水平为203.50(183.75～223.75)mg/L(F=30.92,P<0.001),恢复期NS组血清补体C1q水平为185.00(161.00～202.00)mg/L(F=30.92,P=0.020<0.05),均明显高于正常对照组173.00(161.00～185.00)mg/L; 且急性期NS患儿血清补体C1q水平明显高于恢复期患儿(F=30.92,P<0.001)。Spearman相关性分析显示,NS患儿血清补体C1q水平与TC(r=0.483,P<0.001),TG(r=0.423,P<0.001)和LDL-C(r=0.450,P<0.001)水平均呈正相关,与TP(r=-0.276,P=0.001<0.01),ALB(r=-0.410,P<0.001)呈负相关。逐步多元回归分析显示,在校正其他相关因素的影响下,PNS患儿血清补体C1q水平与TG水平呈高度相关(β=9.235,P<0.001,校正R2=0.215)。结论 PNS患儿血清补体C1q水平明显升高,且与病情和血脂水平相关,有望作为其临床病情评估的新指标。
Abstract:
Objective To analyze serum levels of C1q in children with nephrotic syndrome(NS),and investigate the clinical significance and the relationship among the altered serum C1q levels and other lipid/lipoprotein and renal function parametersin children with NS inacute and remission phases.Methods Serum levels of C1q were measured in 78 NS children with acute phase,in 64NS children with remission and in 77 healthy controlchildren.The other lipid/lipoprotein and renal function parameters were also analyzed in these children,including TP,ALB,TC,TG,LDL-C,HDL-C,Urea,Cr and Uric.Results Compared with the healthy control children [173.00(161.00～185.00)mg/L],children with NS inacute [203.50(183.75～223.75)mg/L] and remission phases [185.00(161.00～202.00)mg/L] all had a significantly increasedserum levels of C1q.Compared with NS children in remission,those in acute phase showed a significantly increased C1q(P<0.001).Inall the NS children,the serum levels of C1q were positively correlated with thelevels of TC(r=0.483,P<0.001),TG(r=0.423,P<0.001)and LDL-C(r=0.450,P<0.001),while negatively correlated with the levels of TP(r=-0.276,P=0.001<0.01)and ALB(r=-0.410,P<0.001).Multiple linear regression analyses showed that serum levels of C1q were independently associated with serum TG levels(β=9.235,P<0.001; adjusted R2=0.215)after adjustment of other related factors.Conclusion Serumlevels of C1q were significantly increased in NS children in association with their conditions and the levels of lipid/lipoprotein parameters,and may be function as anovel parameter for assessing the development of NS.

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备注/Memo

备注/Memo:
基金项目:检验医学国家临床重点专科(2014ZDZK003); 国家自然科学基金资助项目(81572073和81572074)。 作者简介:宋令雄(1986-),男,本科,检验技师,研究方向:临床生化检验和研究,E-mail:songlingx@163.com。 通讯作者:宋佳希(1982-),女,博士,主管技师,研究方向:临床生化检验和研究,E-mail:strive1225@126.com。
更新日期/Last Update: 1900-01-01