[1]黄 芳a,薛 丽a,冯义国b,等.寻常型天疱疮患者血清HSV,CMV和EBV抗体IgG检测的临床意义[J].现代检验医学杂志,2017,32(04):122-124.[doi:10.3969/j.issn.1671-7414.2017.04.035]
　HUANG Fanga,XUE Lia,FENG Yi-guob,et al.Clinical Significance of the Levels of IgG Antibodies Against HSV,CMV and EBV in Patients' Serum with Pemphigus Vulgaris[J].Journal of Modern Laboratory Medicine,2017,32(04):122-124.[doi:10.3969/j.issn.1671-7414.2017.04.035]
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寻常型天疱疮患者血清HSV,CMV和EBV抗体IgG检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
122-124
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Clinical Significance of the Levels of IgG Antibodies Against HSV,CMV and EBV in Patients' Serum with Pemphigus Vulgaris
文章编号:
1671-7414(2017)04-122-03
作者:
黄 芳a; 薛 丽a; 冯义国b; 宋琳岚a; 耿 燕a
西安交通大学第二附属医院a.检验科; b.皮肤科,西安 710004
Author(s):
HUANG Fanga; XUE Lia; FENG Yi-guob; SONG Lin-lana; GENG Yana
a.Department of Clinical Laboratory; b.Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China
关键词:
单纯疱疹病毒;  巨细胞病毒;  EB病毒;  免疫球蛋白G;  寻常型天疱疮
分类号:
R758.66; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.04.035
文献标志码:
A
摘要:
目的 通过评价和比较在寻常型天疱疮患者和健康人抗单纯疱疹病毒1型和2型(HSV1和HSV2),抗巨细胞病毒(CMV)和抗EB病毒(EBV)抗体IgG的水平,研究病毒特别是疱疹病毒在寻常型天疱疮中的意义。方法 23例寻常型天疱疮和26例健康人组成的实验组和对照组,分别从两组中取血清样品,使用ELISA方法检测抗HSV1,抗HSV2,抗CMV和抗EBV的抗体IgG水平。结果 与对照组相比,患者组中的抗四种病毒的抗体IgG水平均有较高表达,而抗EBV,抗CMV和抗HSV2,差异有统计学意义(t=2.16,P<0.05; t=4.76,P<0.01; t=3.75,P<0.01)。而在抗HSV1差异无统计学意义(t=0.52,P>0.05)。结论 在该研究中,排除遗传学、毒素等其它因素的影响外,EBV,CMV和HSV2病毒可能在天疱疮的发病机理中起作用。HSV1和寻常型天疱疮之间没有观察到有统计学差异,在这方面需要进行更多的研究。
Abstract:
Objective To regard the implication of viruses particularly herpes in pemphigus vulgaris,and assess and compare thelevel of immunoglobulin G(IgG)antibodies against herpes simplex virus types 1and 2(HSV1 and HSV2),cytomegalovirus(CMV)and Epstein-Barr virus(EBV)inpatients with pemphigus vulgarisand healthy people.Methods In this study,23 patients with pemphigus vulgaris and 26 healthy individualscomprised the experimental and control groups,respectively.Serum samples weretaken from both groups; the levels of IgG antibodies against HSV1,HSV2,CMV and EBV were measured using ELISA.Results Immunoglobulin Gtiter was higher for all four viruses in the patient group in comparison to thecontrol group.This difference was significant for anti-EBV,anti-CMV and anti-HSV2(t=2.16,P<0.05; t=4.76,P<0.01; t=3.75,P<0.01),respectively,but not significant for anti-HSV1(t=0.52,P>0.05).Conclusion Viruses including EBV,CMV,and HSV2 probably play a rolein the pathogenesis of pemphigus in addition to the effects of genetics,toxinsand other predisposing factors.In this study,no statistically significant relationship was observed between HSV1 and pemphigus vulgaris.More studies must bedone in this regard.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生厅科研基金(2012D67)。 作者简介:黄 芳(1968-),女,硕士,副主任技师,研究方向:自身免疫性疾病的检测,Tel:029-87679344.E-mail:huangfang135720@163.com。 通讯作者:耿 燕,E-mail: wsw87679358@163.com。
更新日期/Last Update: 1900-01-01