[1]黄钰君,伍绍国,丘媛媛,等.广州地区正常儿童血清叶酸参考区间调查[J].现代检验医学杂志,2017,32(04):125-129,132.[doi:10.3969/j.issn.1671-7414.2017.04.036]
 HUANG Yu-jun,WU Shao-guo,QIU Yuan-yuan,et al.Investigation of the Normal Reference Range for Serum Folate of Healthy Children in Guangzhou Region[J].Journal of Modern Laboratory Medicine,2017,32(04):125-129,132.[doi:10.3969/j.issn.1671-7414.2017.04.036]
点击复制

广州地区正常儿童血清叶酸参考区间调查()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
125-129,132
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Investigation of the Normal Reference Range for Serum Folate of Healthy Children in Guangzhou Region
文章编号:
1671-7414(2017)04-125-06
作者:
黄钰君1伍绍国2丘媛媛3蔡敏敏4a陈慧敏4b黎彦攸5
1.广州市儿童医院检验科,广州 510120; 2.广州市第十二人民医院检验科,广州 510620; 3.广州市妇婴医院检验科,广州 510120; 4.广州市妇女儿童医疗中心珠江新城院区a.检验科; b.临床营养科,广州 510000; 5.天津市兰标电子科技发展有限公司,天津 300000
Author(s):
HUANG Yu-jun1WU Shao-guo2QIU Yuan-yuan3 CAI Min-min4aCHEN Hui-min4bLI Yan-you5
1.Department of Laboratory Medicine,Guangzhou Children's Hospital,Guangzhou 510120,China; 2.Department of Laboratory Medicine,Guangzhou Twelfth People's Hospital,Guangzhou 510620, China; 3.Department of Laboratory Medicine,Guangzhou Maternity Health Care Center, Guangzhou 510120,China; 4a.Department of Laboratory Medicine; 4b.Department of Clinical Nutrition,Guangzhou Women and Children Medical Center,Zhujiang New Town Hospital,Guangzhou 510000,China; 6.Lanbiao Science and Technology Ltd,Tianjin 300000,China
关键词:
参考区间 叶酸 血清 广州 儿童
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2017.04.036
文献标志码:
A
摘要:
目的 建立广州地区健康儿童血清叶酸的参考区间。方法 应用LK3000V维生素检测仪对广州地区1 860名健康儿童(男性1 061例,女性799例)和129例成年人(男性52例,女性77例)的血清叶酸进行检测,对结果进行统计分析。结果 ①11岁以内的11个年龄组、11~17岁和成人组血清叶酸水平均无性别差异(P>0.05)。②血清叶酸水平(中位数(P2.5,P97.5)0~1岁(含1岁,下同)组、1~17岁组、成人组分别为9.39(6.12,14.85)nmol/L,,10.65(6.05,16.52)nmol/L和11.12(6.3,17.51)nmol/L,两两比较差异有统计学意义(P<0.05)。③年龄与血清叶酸水平无明显相关性(r=0.039,P=0.09)。结论 广州地区正常儿童血清叶酸水平的参考区间为1岁以内(含1岁)为6.12~14.85 nmol/L,1岁~17岁为6.05~16.52 nmol/L。
Abstract:
Objective To establish the normal reference range for serum folate of healthy children in Guangzhou region.MethodsLevels of serum folate of 1 860 healthy children(1 061 males and 799 females)and 129 adults(52 males and 77 females)living in Guangzhou regionwere examined by LK3000V Vitamin Analyzer.Then the data were analyzed with statistical methods.Results ①There was no statistical difference between boys and girls for levels of serum folate in every group defined by age(P>0.05).②The levels of serum folate [median(P2.5,P97.5)] defined by age were as follows:9.39(6.12,14.85)nmol/L for 0~1 year-old group,10.65(6.05,16.52)nmol/L for 1.01~17 year-old group and 11.12(6.3,17.51)nmol/L for the adult group.Statistical difference was foundbetween any two groups of the three(P<0.05).③No statistical correlationwas found between age and the level of serum folate(r=0.039,P=0.09).Conclusion Reference range for serum folate for healthy children in Guangzhou region include two parts:6.12~14.85 nmol/L for 0~1 year-old group and 6.05~16.52 nmol/L for 1.01~17 year-old group.

参考文献/References:

[1] González-Gross M,Benser J,Breidenassel C,et al.Gender and age influence blood folate,vitamin B12,vitamin B6,and homocysteine levels inEuropean adolescents the helena study[J].Nutr Res,2012,32(11):817-826.
[2] Wald DS,Kasturiratne A,Simmonds M.Effect of folic acid, with or without other B vitamins,on cognitive disorders:meta-analysis of randomized trials[J].Am J Med,2010,123(6):522-527.
[3] Hogeveen M,van Beynum I,van Rooij A,et al.Methylmalonic acid values in healthy Dutch children[J].Eur J Nutr,2008,47(1):26-31.
[4] Kerr MA,Livingstone B,Bates CJ,et al.Folate,related B vitamins,andhomocysteine in childhood and adolescence:potential implications for disease risk in later life[J].Pediatrics,2009,123(2):627-635.
[5] Institute of Medicine(US)Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate,Other B Vitamins,and Choline.Dietary reference intakes for thiamin,riboflavin,niacin,vitamin B6,folate,vitamin B12,pantothenic acid,biotin,and choline[M].Washington(DC):National Academies Press(US),1998.
[6] Bnaa KH,Njlstad I,Ueland PM,et al.Homocysteine lowering and cardiovascular events after acute myocardial infarction[J].N Engl J Med,2006,354(15):1578-1588.
[7] 牛犁天,韩军花,李湖中,等.基于2013版DRIs的微量营养素风险等级划分[J].中国食品添加剂,2016(4):94-98. Niu LT,Han JH,Li HZ,et al.The risk classification of micronutrients from the new edition of Chinese DRI in 2013[J].China Food Additives,2016,(4):94-98.
[8] 任从棉,常娟玲,李志军.血清叶酸和维生素B12检测在巨幼细胞性贫血诊疗中的作用[J]. 现代检验医学杂志.2014,29(5):149-151. Ren CM,Chang JL,Li ZJ.Detction of serum folate and vitamin B12 inthe role of gigantic yong cell anemia diagnosis and treatment[J].J Mod Lab Med,2014,29(5):149-151.
[9] Ganji V,Kafai MR.Trends in serum folate,RBC folate,and circulating total homocysteine concentrations in the United States:analysis of data from National Health and Nutrition Examination Surveys,1988~1994,1999~2000,and 2001~2002[J].J Nutr,2006,136(1):153-158.
[10] 郝 玲,田熠华,谭 明,等.我国部分地区35~64岁人群血浆叶酸水平与年龄性别差异比较[J].营养学报,2002,24(4):352-356. Hao L,Tian YH,Tan M.et al.Comparison study of plasma folate in Chineseadults in genders and ages[J].Acta Nutrimenta Sinica,2002,24(4):352-356.
[11] 王 华,李 敏,吕 莉,等.天津市新婚人群血清叶酸水平现况调查及正常参考值[J].中国妇幼保健,2011,26(30):4698-4701. Wang H,Li M,L(¨overu)L.et al.Cross-sectional investigation on serum folic acid level and normal reference among newly-married population in Tianjin city[J].Maternal and Child Health Care of China,2011,26(30):4698-4701.
[12] 邓 燕,秦 雪,黄 珊,等.广西防城港地区汉族健康成年男性血清叶酸和维生素B12正常参考值的建立[J].中国临床新医学,2011,4(5):413-416. Deng Y,Qin X,Huang S,et al.Reference values for serum levels of B12 and folate in Han ethnic males from the Fangchenggang area[J].Chinese Journal of New Clinical Medicine,2011,4(5):413-416.
[13] 汪运礼,周宗华,王明仲,等.湖北地区健康成人血清叶酸及维生素B12正常值的研究[J].数理医药学杂志,2000,13(1):48-49. Wang YL,Zhou ZH,Wang MZ,et al.Study on serum folic acid and vitamin B12 level in healthy Chinese adults of Hubei region[J].Journal of Mathemaical Medicine,2000,13(1):48-49.
[14] Devalia V,Hamilton MS,Molloy AM,et al.Guidelines for the diagnosis and treatment of cobalamin and folate disorders[J].Br J Haematol,2014,166(4):496-513.
[15] Clinical and Laboratory Standards Institute.Defini-ng,Establishing and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline[S].Wayne:PA,CLSI C28-A3,2008.
[16] Grossi E,Colombo R,Cavuto S,et al.The RELAB project: a new method for the formulation of reference intervals based on current data[J].Clin Chem,2005,51(7):1232-1240.
[17] Katayev A, Balciza C, Seccombe DW.Establishing reference intervals for clinical laboratory test results:is there a better way?[J].Am J Clin Pathol,2010,133(2):180-186.
[18] Shaw JL,Binesh Marvasti T,Colantonio D,et al.Pediatric reference intervals: challenges and recent initiatives[J].Crit Rev Clin Lab Sci,2013,50(2):37-50.
[19] Pfeiffer CM,Caudill SP,Gunter EW,et al.Biochemical indicators of B vitamin status in the US population after folic acid fortification:results fromthe National Health and Nutrition Examination Survey 1999~2000[J].Am J ClinNutr,2005,82(2):442-450.
[20] Al-Tahan J,Sola R,Ruiz JR,et al.Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin,folate,and homocysteine statusin Spanish adolescents[J].Ann Nutr Metab,2008,52(4):315-321.
[21] Papandreou D,Mavromichalis I,Makedou A,et al.Reference range of total serum homocysteine level and dietary indexes in healthy Greek schoolchildren aged 6~15 years[J].Br J Nutr,2006,96(4):719-724.
[22] Huemer M,Vonblon K,F(¨overo)dinger M,et al.Total homocysteine,folate,and cobalamin,and their relation to genetic polymorphisms,lifestyle and bodymass index in healthy children and adolescents[J].Pediatr Res,2006,60(6):764-769.
[23] Shen MH,Chu NF,Wu DM,et al.Plasma homocyst(e)ine,folate and vitamin B(12)levels among school children in Taiwan:The Taipei Children Heart Study[J].Clin Biochem,2002,35(6):495-498.
[24] Akanji AO,Thalib L,Al-Isa AN.Folate,vitamin B12 and total homocysteine levels in Arab adolescent subjects:reference ranges and potential determinants[J].Nutr Metab Cardiovasc Dis,2012,22(10):900-906.
[25] Thomas NE,Cooper SM,Baker JS,et al.Homocyst(e)ine,folate,and vitamin B12 status in a cohort of Welsh young people aged 12-13 years old[J].ResSports Med,2008,16(4):233-243.

相似文献/References:

[1]何涛君a,赵 洁b,王余雪,等.深圳地区营养性巨幼细胞性贫血与同型半胱氨酸水平的相关性研究[J].现代检验医学杂志,2016,31(01):83.[doi:10.3969/j.issn.1671-7414.2016.01.024]
 HE Tao-juna,ZHAO Jieb,WANG Yu-xue,et al.Correlation between Nutritional Megaloblastic Anemia and Homocysteine in Shenzhen[J].Journal of Modern Laboratory Medicine,2016,31(04):83.[doi:10.3969/j.issn.1671-7414.2016.01.024]
[2]张灵玲,张朝明,谢国丽.中性粒VCS参数表达的性别差及差异表达的临床应用[J].现代检验医学杂志,2015,30(06):86.[doi:10.3969/j.issn.1671-7414.2015.06.025]
 ZHANG Ling-ling,ZHANG Chao-ming,XIE Guo-li.Gender Differences of Neutrophil VCS Parameter Expression and Clinical Application of Differential Expression[J].Journal of Modern Laboratory Medicine,2015,30(04):86.[doi:10.3969/j.issn.1671-7414.2015.06.025]
[3]刘晓鸽,姚伟,房笃智.健康成人血浆D-二聚体免疫比浊法正常参考区间的建立[J].现代检验医学杂志,2015,30(06):98.[doi:10.3969/j.issn.1671-7414.2015.06.029]
 LIU Xiao-ge,YAO Wei,FANG Du-zhi.Establishment of the Normal Reference Range of Plasma D-Dimer Immune by Turbidimetric Method in Healthy Adults[J].Journal of Modern Laboratory Medicine,2015,30(04):98.[doi:10.3969/j.issn.1671-7414.2015.06.029]
[4]左 林,赵 佳,姜小建,等.缺血性脑血管病患者血清同型半胱氨酸、叶酸和维生素B12水平与头颈部血管狭窄的相关性研究[J].现代检验医学杂志,2017,32(02):23.[doi:10.3969/j.issn.1671-7414.2017.02.006]
 ZUO Lin,ZHAO Jia,JIANG Xiao-jian,et al.Correlation Study between Serum Homocysteine, Folate,Vitamin B12 Levels and Head and Neck Vascular Stenosis in Patients with Ischemic CerebroVascular Disease[J].Journal of Modern Laboratory Medicine,2017,32(04):23.[doi:10.3969/j.issn.1671-7414.2017.02.006]
[5]张诗诗,王 薇,赵海建,等.我国血清总胆红素和直接胆红素检验项目参考区间现状与即将发布行业标准的分析比较[J].现代检验医学杂志,2017,32(03):152.[doi:10.3969/j.issn.1671-7414.2017.03.043]
 ZHANG Shi-shi,WANG Wei,ZHAO Hai-jian,et al.Analysis and Comparison of Reference Intervals of Serum Total Bilirubin and Serum Direct Bilirubinwith Upcoming I ndustry Standards in China[J].Journal of Modern Laboratory Medicine,2017,32(04):152.[doi:10.3969/j.issn.1671-7414.2017.03.043]
[6]李婷婷,赵海建,王 薇,等.京津冀地区56家临床检验结果互认实验室18个常规化学项目参考区间结果分析[J].现代检验医学杂志,2017,32(06):154.[doi:10.3969/j.issn.1671-7414.2017.06.001]
 LI Ting-ting,ZHAO Hai-jian,WANG Wei,et al.Analysis of Reference Intervals of 18 Routine Biochemistry in 56 Mutual Recognition Laboratories in Beijing-Tianjing-Hebei Region[J].Journal of Modern Laboratory Medicine,2017,32(04):154.[doi:10.3969/j.issn.1671-7414.2017.06.001]
[7]吴爽,张书婉,张涛元,等.西安地区0~12岁健康儿童血清S100蛋白参考区间的建立[J].现代检验医学杂志,2019,34(01):124.[doi:10.3969/j.issn.1671-7414.2019.01.032]
 WU Shuang,ZHANG Shu-wan,ZHANG Tao-yuan,et al.Establishment of Biology Reference Interval of Serum Protein S100 Level in Healthy Children between 0 and 12 Years Old in Xi’an[J].Journal of Modern Laboratory Medicine,2019,34(04):124.[doi:10.3969/j.issn.1671-7414.2019.01.032]
[8]张 燕,王伟红,郝万鹏.乌鲁木齐汉族妇女亚甲基四氢叶酸还原酶基因变异与血清叶酸和同型半胱氨酸水平的相关性研究[J].现代检验医学杂志,2019,34(05):98.[doi:10.3969/j.issn.1671-7414.2019.05.024]
 ZHANG Yan,WANG Wei-hong,HAO Wan-peng.Study on the Correlation between the Variation of Methylenetetrahydrofolate Reductase Gene and Folate and Homocysteine in Urumqi Han Women[J].Journal of Modern Laboratory Medicine,2019,34(04):98.[doi:10.3969/j.issn.1671-7414.2019.05.024]
[9]史剑飞,卢北玲,李 俏,等.西安地区健康儿童血清缺血修饰清蛋白参考区间的建立[J].现代检验医学杂志,2019,34(06):118.[doi:10.3969 / j.issn.1671-7414.2019.06.029]
 SHI Jian-fei,LU Bei-ling,LI Qiao,et al.Establishment of Reference Interval for Serum Ischemic Modified Albumin of Healthy Children in Xi’an Area[J].Journal of Modern Laboratory Medicine,2019,34(04):118.[doi:10.3969 / j.issn.1671-7414.2019.06.029]
[10]谭玉华,曹春玲,邢晓敏,等.国产Auto TRFIA-4 型自动荧光免疫分析仪与试剂盒检测妊娠相关血浆蛋白A 的性能评价与参考区间的建立[J].现代检验医学杂志,2020,35(04):75.[doi:10.3969/j.issn.1671-7414.2020.04.018]
 TAN Yu-hua,CAO Chun-ling,XING Xiao-min,et al.Performance Evaluation of Domestic Auto TRFIA-4 Model Automatic Fluorescence Immunoassay and Kit for Detection of Pregnancy Associatied Plasma Protein A and Establishment of Reference Interval[J].Journal of Modern Laboratory Medicine,2020,35(04):75.[doi:10.3969/j.issn.1671-7414.2020.04.018]

备注/Memo

备注/Memo:
基金项目:A2016531。 作者简介:黄钰君(1978-),女,硕士,临床医学检验副主任技师,主要从事儿童血液学检验工作,Tel:13662514487,E-mail:korakorakora@163.com。
更新日期/Last Update: 1900-01-01