[1]阿地拉·阿布里孜,刘 敏.miR-126在血液透析并发冠心病患者中检测的临床意义[J].现代检验医学杂志,2017,32(05):97-99.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　ADILA·Abulizi,LIU Min.Clinical Significance of Detecting miR-126 in Hemodialysis with Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2017,32(05):97-99.[doi:10.3969/j.issn.1671-7414.2017.05.017]
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miR-126在血液透析并发冠心病患者中检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
97-99
栏目:
论著
出版日期:
2017-11-02

文章信息/Info

Title:
Clinical Significance of Detecting miR-126 in Hemodialysis with Coronary Artery Disease
文章编号:
1671-7414(2017)05-097-03
作者:
阿地拉·阿布里孜1; 刘 敏2
1.新疆维吾尔自治区人民医院肾病科,乌鲁木齐 830001; 2.新疆喀什地区第一人民医院血液透析科,新疆喀什 844000
Author(s):
ADILA·Abulizi1; LIU Min2
1.Department of Nephropathy,Xinjiang Uygur Autonomous Region People's Hospital,Urumqi 830001,China; 2.Departmentof Hemodiaglysis, the First People's Hospital of Kashi Xinjiang,Xinjiang Kashi 844000,China
关键词:
血液透析;  冠心病;  miR-126
分类号:
R541.4; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.05.017
文献标志码:
A
摘要:
目的 探讨血液透析并发冠心病患者检测miR-126的临床意义。方法 血液透析患者60例中并发冠心病组(A组)35例,其中单支病变12例,双支病变13例,多支病变10例。无并发冠心病组(B组)25例。正常对照组(C组)40例。茎环逆转录荧光定量PCR检测miR-126表达水平并进行统计学分析。结果 A组miR-126表达量为0.228±0.023,比C组(0.356±0.027)和B组(0.371±0.022)均低(F=5.32,P<0.5)。其中A组分别与B组和C组比较差异均有统计学意义(t=6.32～8.35,均P<0.05)。单支病变组miR-126表达量为0.246±0.025,双支病变组为0.228±0.021,多支病变组为0.206±0.019,三组比较差异均有统计学意义(F=6.15,均P<0.05)。其中两两比较差异均无统计学意义(t=8.41～11.65,均P<0.05)。结论 miR-126检测对血透患者透析时限预警有无并发冠心病意义重大。
Abstract:
Abstract:Objective To investigate the clinical significance and level changes of miR-126 on hemodialysis patients.Methods60 cases from hemodialysis were divided into patients with coronary artery disease(35cases),including single coronary artery lesion(12cases)and two coronary artery lesion(13cases)and coronary multivessel lesions(10cases),or no coronary artery disease(25cases).They were detected miR-126 expression by real-time PCR.Results There were obvious differences of miR-126 expression levels between patients and normal group(F=5.32,P<0.05),and obvious differences of A groups and B groups,or C groups(t=6.32～8.35,all P<0.05).Among single coronary artery lesion,two coronary artery lesion,and coronary multivessel lesions,there were obvious differences of miR-126 expression levels(F=6.15,P<0.05).The single coronary artery lesion had a higher miR-126 expression levels than those of two coronary artery lesion and coronary multivessel lesions(t=8.41～11.65,all P<0.05).Conclusion Detection of miR-126 expression levels could be related to hemodialysis with coronary artery disease.

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备注/Memo

备注/Memo:
作者简介:阿地拉·阿布里孜(1974-),女,硕士学位,主任医师,主要从事血液透析患者诊疗。
更新日期/Last Update: 1900-01-01