[1]李丽春,张红莉,南 刚.多囊卵巢综合征患者血清IL-23水平的检测及临床意义[J].现代检验医学杂志,2017,32(05):108-109.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　LI Li-chun,ZHANG Hong-li,NAN Gang.Clinical Significance of Serum IL-23 Levels in Patients with Polycystic Ovary Syndrome(PCOS)[J].Journal of Modern Laboratory Medicine,2017,32(05):108-109.[doi:10.3969/j.issn.1671-7414.2017.05.017]
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多囊卵巢综合征患者血清IL-23水平的检测及临床意义()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
108-109
栏目:
论著
出版日期:
2017-11-02

文章信息/Info

Title:
Clinical Significance of Serum IL-23 Levels in Patients with Polycystic Ovary Syndrome(PCOS)
文章编号:
1671-7414(2017)05-108-03
作者:
李丽春,张红莉,南 刚
延安大学附属医院产科一病区,陕西延安 716000
Author(s):
LI Li-chun,ZHANG Hong-li,NAN Gang
Department of Obstetrics and Gynecology; Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China
关键词:
IL-23;  多囊卵巢综合征;  慢性炎症
分类号:
R711.75; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.05.017
文献标志码:
A
摘要:
目的 血清IL-23表达水平在多囊卵巢综合征(polycysticovary syndrome,PCOS)患者中的检测及其临床意义。方法 选取在延安大学附属医院就诊的50例PCOS患者为观察组,同时选取50例健康女性为正常对照组。采用生化分析仪检测血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)的水平; 血细胞计数仪检测白细胞(white blood cell,WBC)的含量; ELISA法检测血清IL-23的表达水平。结果 观察组患者血清WBC水平分别为8 056.1±2 473.6 mm3,显著高于对照组的6 286.2±1 071.4 mm3,差异有统计学意义(t=4.642,P<0.001),而hs-CRP在两组则无明显差异(观察组为4.2±3.7 mg/L,对照组为3.9±3.2 mg/L,t=0.434,P=0.665); PCOS患者血清IL-23水平为59.6±40.1 pg/ml,显著高于健康女性人群(29.7±20.5 pg/ml),差异有统计学意义(t=4.695,P<0.001); PCOS患者血清IL-23诊断的最佳cutoff值为31.05 pg/ml,其中敏感度74.0%,特异度62.0%,AUC值0.729(95%CI范围0.630～0.827,P<0.001)。结论 PCOS患者血清IL-23水平显著上升,两者呈显著的正相关,可作为PCOS诊断的生物标志物之一。
Abstract:
Abstract:Objective To investigate and detect serum IL-23 levels in patients with PCOS.Methods A total of 50 PCOS patients in the Affiliated Hospital of Yan'an University as the observed group and 50 healthy women as control group were studied in this research.Serum levels of high-sensitivity C-reactive protein(hs-CRP)were measured through biochemical analyzer; White blood cell(WBC)was measured through automatic blood cell counter; The expression of serum IL-23 were measured by ELISA.Results Serum WBC levels were significantly higher in observed group than those in control group(8 056.1±2 473.6 mm3 and 6 286.2±1 071.4 mm3,t=4.642,P<0.001).Besides,serum hs-CRP in two groups were no significant difference(observed group 4.2±3.7 mg/L and control group 3.9±3.2 mg/L,t=0.434,P=0.665).Furthermore,compared with control group,serum IL-23 levels were significantly higher in observed group and there was significant difference between the two groups(59.6±40.1 pg/ml and 29.7±20.5 pg/ml,t=4.695,P<0.001).The best cutoff value for serum IL-23 concentration to diagnose PCOS was 31.05 pg/ml(sensitivity 74.0%,specificity 62.0%,and AUC 0.729,95%CI:0.630～0.827,P<0.001).Conclusion Women with PCOS had higher serum IL-23 levels and there were significantly positive correlated.IL-23 could be a biomarker for PCOS diagnosis.

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备注/Memo

备注/Memo:
作者简介:李丽春(1977-),女,本科,副主任医师,研究方向:产科,E-mail:lilichun1977a@163.com。
更新日期/Last Update: 1900-01-01