[1]刘小玲,李卫国,李振华.2型糖尿病患者颈动脉内-中膜厚度与血清IL-6和Fetuin-A水平的关系研究刘小玲,李卫国,李振华[J].现代检验医学杂志,2017,32(05):115-117.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　LIU Xiao-ling,LI Wei-guo,LI Zhen-hua.Study on the Relationship of Carotid Intimal-Medial Wall Thickness and the Expression of IL-6 and Fetuin-A in the Serum of Two Type Diabetes[J].Journal of Modern Laboratory Medicine,2017,32(05):115-117.[doi:10.3969/j.issn.1671-7414.2017.05.017]
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2型糖尿病患者颈动脉内-中膜厚度与血清IL-6和Fetuin-A水平的关系研究刘小玲,李卫国,李振华()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
115-117
栏目:
论著
出版日期:
2017-11-02

文章信息/Info

Title:
Study on the Relationship of Carotid Intimal-Medial Wall Thickness and the Expression of IL-6 and Fetuin-A in the Serum of Two Type Diabetes
文章编号:
1671-7414(2017)05-115-03
作者:
刘小玲; 李卫国; 李振华
新疆喀什地区第一人民医院干部病房,新疆喀什 844000
Author(s):
LIU Xiao-ling; LI Wei-guo; LI Zhen-hua
Cadre Ward of the First People's Hospital of Kashi Xinjiang,Xinjiang Kashi 844000,China
关键词:
内-中膜厚度;  白细胞介素6(IL-6);  胎球蛋白A;  动脉粥样硬化
分类号:
R587.1; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.05.017
文献标志码:
A
摘要:
目的 探讨白细胞介素6(IL-6)和胎球蛋白A(Fetuin-A)水平与2型糖尿病患者颈动脉内-中膜厚度的关系。方法 选取2型糖尿病患者80例为试验组,健康体检者60例为对照组,通过酶联免疫吸附法检测研究对象血清IL-6和Fetuin-A水平,应用颈动脉多普勒彩色超声检查颈动脉内-中膜厚度(intimal-medial wall thickness,IMT)。结果 2型糖尿病患者血清IL-6水平明显高于对照组,Fetuin-A水平明显低于对照组(t=8.34～15.65,均P<0.05)。颈动脉内-中膜厚度正常者(A组,20例)IL-6水平为2.24±0.21 pg/L,Fetuin-A水平为5.41±0.32 ng/ml; 内膜增厚患者(B组,18例)IL-6水平为3.44±0.18 pg/L,Fetuin-A水平为3.86±0.42 ng/ml; 斑块形成患者(C组,22例)IL-6水平为4.95±0.31 pg/L,Fetuin-A水平为2.41±0.32 ng/ml; 管腔狭窄患者斑块组(D组,20例)IL-6水平为5.35±0.31 pg/L,Fetuin-A水平为2.02±0.08 ng/ml。四组IL-6和Fetuin-A水平差异均有统计学意义(F=8.69～11.02,均P<0.05)。其中A组～D组IL-6水平逐渐升高,组间差异均有统计学意义(t=5.32～9.01,均P<0.05)。而Fetuin-A水平逐渐降低,组间差异也有统计学意义(t=6.14～11.53,均P<0.05)。结论 IL-6和Fetuin-A水平与2型糖尿病患者内-中膜厚度有关,可预见2型糖尿病患者有无动脉粥样硬化。
Abstract:
Abstract:Objective To investigate the relationship of carotid intimal-medial wall thickness(IMT)and the expression of IL-6 and Fetuin-A in two type diabetes.Methods 80 patients with two type diabetes were chosen,and 60 cases healthypeople of examination for the control group.The levels of IL-6 and Fetuin-A were measured,and measured the intimal-medial thickness(IMT)of internal carotid artery by carotid duplex ultrasonography scanning simultaneously.Results The level of IL-6 was significantly higher in two type diabetes than those in control group,and the level of Fetuin-A was declind(t=8.34～15.65,all P<0.05).IL-6 level in normal IMT(A group,20 cases)was 2.24±0.21 pg/L,Fetuin level was 5.41±0.32 ng/ml.IL-6 level in abnormal IMT(B group,18 cases)was 3.44±0.18 mm,and Fetuin level was 3.86±0.42 ng/ml.Relatively,IL-6 level in IMT with plaque(C group,22 cases)was 4.95±0.31 ng/ml,Fetuin-A level was 2.41±0.32 ng/ml.IL-6 level in lumen narrow(D group,20 cases)was 5.35±0.31 ng/ml,and Fetuin-A level was 2.02±0.08 ng/ml.There were obvious differences for four groups to detect IL-6 was Fetuin-A levels(F=8.69～11.02,all P<0.05).The level of IL-6 were rised little by little from A group to D group.There were obvious differences for comparison among groups(t=5.32～9.01,all P<0.05).The level of Fetuin-A were declined little by little from A group to D group,there were obvious differnce for comparison among groups(t=6.14～11.53,all P<0.05).Conclusion There was a close correlation between IL-6,Fetuin-A level and carotid intimal-medial wall thickness(IMT)in two type diabetes.To detection IL-6 and Fetuin-A levels is a target to distinguish two type diabetes whether or not with atherosclerosis.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:刘小玲(1974-),女,副主任医师,主要从事心血管疾病的诊疗工作。
更新日期/Last Update: 1900-01-01