[1]白金娥a,林小艳b.外周血NLR与PLR对急性肺梗死患者预后价值探析[J].现代检验医学杂志,2017,32(05):137-140,144.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　BAI Jin-ea,LIN Xiao-yanb.Prognosis Affects of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio of Peripheral Blood for Patients with Acute Lung Infarction[J].Journal of Modern Laboratory Medicine,2017,32(05):137-140,144.[doi:10.3969/j.issn.1671-7414.2017.05.017]
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外周血NLR与PLR对急性肺梗死患者预后价值探析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
137-140,144
栏目:
检验与临床
出版日期:
2017-11-02

文章信息/Info

Title:
Prognosis Affects of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio of Peripheral Blood for Patients with Acute Lung Infarction
文章编号:
1671-7414(2017)05-137-05
作者:
白金娥a; 林小艳b
延安大学附属医院a.急诊科; b.高压氧科,陕西延安 716000
Author(s):
BAI Jin-ea; LIN Xiao-yanb
a.Department of Emergency; b.Department of Hyperbaric Oxygen, the Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China
关键词:
嗜中性粒细胞与淋巴细胞比值;  血小板与淋巴细胞比值;  急性肺梗死;  预后
分类号:
R563.5; R446.111
DOI:
10.3969/j.issn.1671-7414.2017.05.017
文献标志码:
A
摘要:
目的 主要探析嗜中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)对急性肺梗死(acute plumonary embolism,APE)患者预后价值。方法 收集了2010年4月～2015年4月期间急性肺梗死患者164例,分为生存组(n=136)和死亡组(n=28),收集了患者的基本临床病理、生化数据,以评估相关性。结果 发现164例APE患者的死亡率为17.07%(28/164)。多变量Logstic回归分析发现较低的收缩压(OR=0.923,95%CI:0.872～0.991,P=0.016)和Wells评分(OR=1.138,95%CI:1.002～1.478,P=0.036)、较高的肺动脉收缩压(OR=1.090,95%CI:1.031～1.316,P=0.014)、NLR(OR=1.132,95%CI:1.040～1.238,P=0.012)、PLR(OR=1.002,95%CI:1.000～1.009,P=0.010)、脑钠肽(OR=1.002,95%CI:1.000～1.007,P=0.017)、PESI得分(OR =1.100,95%CI:1.032～1.200,P=0.012)是APE患者死亡的显著独立危险因素,且NLR和PLR与其它显著的独立危险因素之间显著相关。Kaplan-Meier曲线分析发现NLR ≤5.64,PLR≤184的APE患者的总生存期均显著高于NLR>5.64,PLR>184的患者(P=0.01)。结论 NLR及PLR可以作为APE患者的独立预后因子,且较高NLR和PLR的患者死亡的危险性较大。
Abstract:
Abstract:Objective To described the prognosis affects of blood neutrophil to lymphocyte and platelet to lymphocyte for acute plumonary embolism patients.Methods Collected 164 acute plumonary embolism patients from 2010 to 2015,and they were divided into survivor group(n=136)and death group(n=28).And collected the data for basic clinical pathological and biochemical characteristics,to assess the correlation.Results The study found that the mortality of 164 cases of APE patients was 17.07%(28/164).Multivariate Logstic regression analysis found that the lower systolic blood pressure(OR=0.923,95% CI:0.872～0.991,P=0.016)and the wells score(OR=1.138,95% CI:1.002～1.478,P=0.036),higher pulmonary artery systolic pressure(OR=1.090,95% CI:1.031～1.316,P=0.014),NLR(OR=1.132,95% CI:1.040～1.238,P=0.012),PLR(OR=1.002,95% CI:1.000～1.009,P=0.010),brain natriuretic peptide(OR=1.002,95% CI:1.000～1.007,P=0.017),PESI score(OR=1.100,95% CI:1.032～1.200,P=0.012)were the significant independent risk factors of death for patients with APE, NLR and PLR had significant correlation with other significant independent risk factors.Kaplan-Meier curve analysis found that the overall survival of APE patients with NLR≤5.64,PLR≤184 were significantly higher than APE patients with NLR>5.64,PLR>184(P=0.01),respectively.Conclusion NLR and PLR could be used as independent prognostic factors in patients with acute pulmonary embolism,and the risk of death was higher in patients with higher level NLR or PLR.

参考文献/References:

[1] Torbicki A,Perrier A,Konstantinides S,et al.Guidelines on thediagnosis and management of acute pulmonary embolism:the task force for the diagnosis and management of acute pulmonary embolism of the european society of cardiology(ESC)[J].European Heart Journal,2008,29(18):2276-2315.
[2] Agnelli G, Becattini C.Acute pulmonary embolism[J].New England Journal of Medicine,2010,363(3):266-274.
[3] Zee RY,Glynn RJ,Cheng S,et al.An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism:TheWomen's Genome Health Study[J].Circulation Cardiovascular Genetics,2009,2(1):57-62.
[4] Balta S,Demirkol S,Kucuk U.The platelet lymphocyte ratio may be usefulinflammatory indicator in clinical practice[J].Hemodialysis International,2013,17(4):668-669.
[5] Temiz A,Gazi E,G(¨overu)ng(¨overo)r(¨overO),et al.Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction[J].Medical Science Monitor,2014,20(233):660-665.
[6] 胡 琼,余 倩,熊 方,等.肺血栓栓塞症患者血液中炎症指标的变化[J].贵州医药,2016,40(2):159-161.
[7] Goldhaber SZ,Visani L,de Rosa MD.Acute pulmonary embolism.Clinical outcomes in the International Cooperative Pulmonary Embolism Registry(ICOPER)[J].Lancet,1999,353(9162):1386-1389.
[8] 刘 歆,刘少滨.310例肺栓塞临床预后和生存分析研究[D].福州:福建医科大学,2015. Liu X,Liu SB.Prognosis analysis and survival analysis in 310 patients of pulmonary thromboembolism[D].Fuzhou:Fujian Medical University,2015.
[9] Afzal A,Noor HA,Cill SA,et al.Leukocytosis in acute pulmonary embolism[J].Chest,1999,115(5):1329-1332.
[10] 丁 洁,郭晓纲.肺栓塞危险因素与预后评价的研究进展[J].中华危重症医学杂志(电子版),2016,9(1):58-66.
[11] 秦艳茹,张春芳.急性肺栓塞患者血小板动态变化与预后的相关性分析[J].临床肺科杂志,2016,21(7):1264-1267. Qin YR,Zhang CF.Correlation analysis between dynamic platelet variation and prognosis in patients with acute pulmonary embolism[J].Journal Clinical Pulmonay Medicine,2016,21(7):1264-1267.
[12] Sunbul M,Gerin F,Durmus E,et al.Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension[J].Clinical & Experimental Hypertension,2014,36(4):217-221.
[13] Ghaffari S,Nadiri M,Pourafkari L,et al.The predictive value of totalneutrophil count and neutrophil/lymphocyte ratio in predicting in-hospital mortality and complications after STEMI[J].Journal of Cardiovascular & ThoracicResearch,2014,6(1):35-41.
[14] Cavus UY,Yildirim S,S(¨overo)nmez E,et al.Prognostic value of neutrophil/lymphocyte ratio in patients with pulmonary embolism[J].Turkish Journal of Medical Sciences,2014,44(1):50-55.
[15] 刘挺挺,李 虎,马 炜,等.重症肌无力患者外周血中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值的临床意义[J].现代检验医学杂志,2016,131(1):65-68. Liu TT,Li H,Ma W,et al.Clinical significance of neutrophils/lymphocyteand platelet/lymphocyte ratio of peripheral blood in patients with myasthenia gravis[J].J Mod Lab Med,2016,31(1):65-68.
[16] Yildiz A,Yuksel M,Oylumlu M,et al.The utility of the platelet-lymphocyte ratio for predicting no reflow in patients with ST-segment elevation myocardial infarction[J].Clinical & Applied Thrombosis/hemostasis,2015,21(3):223-228.

备注/Memo

备注/Memo:
作者简介:白金娥(1983-),女,本科,主治医师,主要从事呼吸系统及心脑血管系统急危重症,E-mail:baijine1983419@163.com。 通讯作者:林小艳,主治医师,E-mail:63695808@qq.com。
更新日期/Last Update: 1900-01-01