[1]曹 英,刘春华,杨亚莉.孕妇血清淀粉样蛋白A水平检测与早期原发性不明原因复发性流产的临床相关性研究[J].现代检验医学杂志,2017,32(06):43-45,49.[doi:10.3969/j.issn.1671-7414.2017.06.001]
 CAO Ying,LIU Chun-hua,YANG Ya-li.Clinical Research on Detecting the Serum Amyloid A Level of Pregnant Woman in Early Primary Unexplained Recurrent Spontaneous Abortion[J].Journal of Modern Laboratory Medicine,2017,32(06):43-45,49.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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孕妇血清淀粉样蛋白A水平检测与早期原发性不明原因复发性流产的临床相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
43-45,49
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Clinical Research on Detecting the Serum Amyloid A Level of Pregnant Woman in Early Primary Unexplained Recurrent Spontaneous Abortion
文章编号:
1671-7414(2017)05-043-04
作者:
曹 英刘春华杨亚莉
宝鸡市妇幼保健院产科,陕西宝鸡 721000
Author(s):
CAO YingLIU Chun-huaYANG Ya-li
Department of Obstetrics, Baoji Maternal and Child Care Hospital,Shaanxi Baoji 721000,China
关键词:
原发性不明原因早期复发性流产 血清淀粉样蛋白A 合胞体化 滋养细胞侵入
分类号:
R714.21; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 检测原发性不明原因早期复发性流产(recurrent early pregnancy loss,REPL)孕妇血清淀粉样蛋白A(serum amyloid A,SAA)水平,并探讨其对不明原因REPL的预测价值。方法 将2014年1~12月间宝鸡市妇幼保健院妇产科收治的96例原发性不明原因REPL孕妇作为REPL组,并以96例无REPL史的正常孕妇作为对照组。采用酶联免疫法检测两组患者血清SAA水平,多因素Logistic回归分析REPL发病的危险因素,并采用ROC曲线评估SAA对REPL的诊断价值。结果 REPL组孕妇血清SAA中位浓度(50.0 μg/ml)显著高于正常孕妇(11.6 μg/ml)(Z=2.153,P=0.000<0.01)。SAA对REPL的诊断价值较高(AUC=0.91),最佳筛查阳性界值为18μg/ml。矫正孕妇年龄和孕周因素,SAA水平是原发性不明原因REPL发生的危险因素(OR值:1.12,P=0.000)。结论 原发性不明原因REPL孕妇血清SAA水平升高可作为REPL发病的新的生物标志。
Abstract:
Abstract:Objective To research the serum amyloid A(SAA)levels of primary unexplained recurrent early pregnancy loss(REPL),and discuss the viability of regarding the SAA as a independent indicator of REPL.Methods A prospective study was conducted among 96 women with missed spontaneous abortion at Baoji Maternal and Child Care Hospital from January to December 2014.A control group was formed of pregnant women with no history of REPL.Serum samples of both groups were collected to measure SAA levels by enzyme linked immunosorbent assay.The association between SAA and primary unexplained REPL were analyzed according to the multiple factors Logistic models,and the diagnostic value of SAA to REPL were detected through receiver operating characteristic.Results Median SAA level was significantly higher among women withREPL(50 μg/ml,interquartile range 26.0~69.0 μg/ml),than that in the control group(11.6 μg/ml,interquartile range 6.2~15.5 μg/ml,P=0.000<0.01).The diagnose value of SAA to REPL was perfect good(AUC=0.91),andthe most accurate value was 18 μg/ml.The SAA level was an independent indicator of primary unexplained REPL,after adjusting for maternal age and gestational age(OR:1.12,P=0.000).Conclusion Elevated SAA levels found among women with primary unexplained REPL could represent anovel biomarker for this complication of pregnancy.

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备注/Memo

备注/Memo:
基金项目:宝鸡市2013年科学技术研究发展计划项目(13SF4_2)。 作者简介:曹 英(1977-),女,本科,主治医师,研究方向:产科门诊孕妇膳食营养指导及妇科肿瘤临床治疗,E-mail:caoying197711@126.com。 通讯作者:杨亚莉(1978-),女,本科,主治医师,研究方向:产后康复,E-mail:longxianrenda@163.com。
更新日期/Last Update: 2017-12-26