[1]严晓华,白涛敏,马 娟,等.儿童川崎病患者血浆和肽素,IL-17A,TNF-α检测与冠脉病变的相关性研究[J].现代检验医学杂志,2017,32(06):50-52.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　YAN Xiao-hua,BAI Tao-min,MA Juan,et al.Study on the Relationship between Peptides and Interleukin-17A, Tumor Necrosis Factor α in Children Kawasaki Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2017,32(06):50-52.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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儿童川崎病患者血浆和肽素,IL-17A,TNF-α检测与冠脉病变的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
50-52
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Study on the Relationship between Peptides and Interleukin-17A, Tumor Necrosis Factor α in Children Kawasaki Coronary Artery Disease
文章编号:
1671-7414(2017)06-050-03
作者:
严晓华; 白涛敏; 马 娟; 贺 望; 高 娜; 周 南
陕西省人民医院 西安交通大学医学院第三附属医院,西安 710068
Author(s):
YAN Xiao-hua; BAI Tao-min; MA Juan; HE Wang; GAO Na; ZHOU Nan
Shaanxi Provincal People's Hospital,the Third Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710068,China
关键词:
儿童川崎病;  和肽素;  白介素17A;  肿瘤坏死因子α;  冠脉病变
分类号:
R725.5; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 探讨血浆和肽素,IL-17A及TNF-α在儿童川崎病冠脉病变中的诊断意义。方法 选取经临床确诊的川崎病冠脉病变患儿60例(男性32例,女性28例,平均年龄2.5岁),同时选取健康体检儿童40例(男性23例,女性17例,平均年龄3岁)为对照组。采用酶联免疫吸附试验(ELISA)法检测各组血浆和肽素、白介素17A(IL-17A)、肿瘤坏死因子α(TNF-α)的含量。结果 ①川崎病冠脉病变组血浆中的和肽素(21.09±2.72 pmol/L),IL-17A(21.20±2.35 pg/ml),TNF-α(50.84±5.81 pg/ml)含量均高于对照组(18.45±2.96 pmol/L,18.80±2.20 pg/ml,45.24±6.15 pg/ml),t=6.13,8.586,7.278,均P<0.01。②受试者工作曲线(receiver operating characteristic curve,ROC)显示,和肽素预测川崎病冠脉病变敏感度为88.2%,特异度为75.0%; IL-17A敏感度为85.3%,特异度为79.2%; TNF-α敏感度为88.2%,特异度为73.6%。结论 川崎病冠脉病变患儿急性期血浆和肽素,IL-17A和TNF-α水平均升高,三者联合可以预测川崎病患儿冠脉病变的发生。
Abstract:
Abstract:Objective To investigate the diagnostic valueof Peptides and Interleukin-17A,Tumor necrosis factorαin children kawasaki coronary artery disease.Methods 60 patients,made adefinite diagnosis as kawasaki coronary artery disease(32 cases of male,28 cases of female,average age 2.5 years),40 healthy subject were enrolled in the study(23 cases of male,female 17 cases,with an average age of 3 years of age).The plasma levels of Peptides,Interleukinin 17A(IL-17A)and Tumor necrosis factorα(TNF-α)in each group was detected by ELISA.Results ①The plasma levels of Peptides,Interleukinin 17A(IL-17A)and Tumor necrosis factorα(TNF-α)was significantly higher than healthy controls,respectively(21.09±2.72)vs(18.45±2.96)pmol/L,t=6.13,P<0.01,(21.20±2.35)vs(18.80±2.20)pg/ml,t=8.586,P<0.01;(50.84±5.81)vs(45.24±6.15)pg/ml,t=7.278,P<0.01.②Results of ROC curves showed,the sensitivity of Peptides in kawasaki coronary artery disease was 88.2%,thespecificity was 75.0% and the sensitivity of IL-17A was 85.3%,the specificity was 79.2%,the sensitivity of TNF-α was 88.2%,the specificity was 73.6%.Conclusion The plasma levels of Peptides,IL-17A and TNF-α in acute phase of kawasaki coronary artery disease were all increased.Combined detections of peptide,IL-17A and TNF-α may predict the incidence of coronary artery disease in children with kawasaki disease.

参考文献/References:

[1] 中华医学会儿科分会心血管学组,中华医学会儿科分会免疫学组,《中华儿科杂志》编辑委员会.川崎病冠状动脉病变的临床处理建议[J].中华儿科杂志,2012,50(10):746-749. Chinese Pediatric Society,Chinese Medical Association Cardiovascular Group.Chinese Pediatric Society,Chinese Medical Association Immunology Group,《ChineseJournal of Pediatrics》Editorial Committee.Kawasaki disease of coronary arterylesions in clinical treatment advice[J].Chinese Journal Pediatrics,2012,50(10):746-749.
[2] Tu WJ,Ma GZ,Ni Y,et al.Copeptin and NT-proBNP for prediction of all-cause and cardiovascular death in ischemic stroke[J].Neurology,2017,88(20):1899-1905.
[3] Jia J,Chang GL,Qin S,et al.Comparative evaluation of copeptin and NT-proBNP in patients with severe acute decompensated heart failure,and prediction of adverse events in a 90-day follow-up period:A prospective clinical observation trial[J].Exp Ther Med,2017,13(4):1554-1560.
[4] Zittema D,van Den Brand JA,Bakker SJ,et al.Copeptin,a surrogate marker for arginine vasopressin,is associated with disease severity and progressionin IgA nephropathy patients[J].Nephrol Dial Transplant,2017,32(suppl 1):i146-i153.
[5] 严晓华,高 娜,周 南.170例儿童川崎病临床分析[J].昆明医科大学学报,2016,36(10):122-124. Yan XH,Gao N,Zhou N.Clinical analysis of 170 cases of children kawasaki disease[J].Journal of Kunming Medical University,2016,36(10):122-124.
[6] Chen YL,Wang JL,Li WQ.Prediction of the risk of coronary arterial lesions Kawasaki disease by serum 25-hydroxyvitamin D3[J].Eur J Pediatr,2014,173(11):1467-1471.
[7] Galeotti C,Kaveri SV,Cimaz R,et al.Predisposing factors,pathogenesisand therapeutic intervention of Kawasaki disease[J].Drug Discov Today,2016,21(11):1850-1857.
[8] Stengaard C,Sorensen JT,Ladefoged SA,et al.The potential of optimizing prehospital triage of patients with suspected acute myocardial infarction using high-sensitivity cardiac troponin T and copeptin[J].Biomarkers,2017,22(3-4):351-360.
[9] Zabarovskaja S,Hage C,Gabrielsen A,et al.Copeptin in heart failure,post-left ventricular assist device and post-heart transplantation[J].HeartLung Circ,2017,26(2):143-149.
[10] 汪 芸,崔小岱,伏 瑾,等.川崎病心肌和冠状动脉损伤与血清TNF-α和IL-6水平的研究[J].北京医学,2011,33(5):395-398. Wang Y,Cui XD,Fu J,et al.The study on level of serum TNF alpha,IL-6levels and its role in myocardial injury coronary artery lessions in children with Kawasaki disease[J].Beijing Medical Journal,2011,33(5):395-398.
[11] 王娟莉,周 南,苏德成,等.川崎病患儿血11β-羟基类固醇脱氢酶的变化研究[J].中国妇幼健康研究,2013,24(5):643-645. Wang JL,Zhou N,Su DC,et al.Changes in 11 beta-Hydroxysteroid Dehydrogenase level in plasma of Children with Kawasaki Disease[J].Chinese Journal Women's and Child Health Research,2013,24(5):643-645. 收稿日期:2017-07-16 修回日期:2017-08-04

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展科技攻关项目(2015SF130)。 作者简介:严晓华(1981-),女,硕士研究生,副主任医师,主要从事儿童川崎病、肾病等风湿免疫相关性疾病的研究,E-mail:105490180@qq.com。 通讯作者:马 娟,女,主治医师,E-mail:18991903955@163.com。
更新日期/Last Update: 2017-12-26