[1]朱 峰,张 鹏,宋建荣,等.EDNRA基因rs5335多态性与aSAH后迟发性脑血管痉挛的关联性研究[J].现代检验医学杂志,2017,32(06):56-59.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　ZHU Feng,ZHANG Peng,SONG Jian-rong,et al.Association between Polymorphism of Endothelin Receptor Type A and Delayed Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage[J].Journal of Modern Laboratory Medicine,2017,32(06):56-59.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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EDNRA基因rs5335多态性与aSAH后迟发性脑血管痉挛的关联性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
56-59
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Association between Polymorphism of Endothelin Receptor Type A and Delayed Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
文章编号:
1671-7414(2017)06-056-04
作者:
朱 峰; 张 鹏; 宋建荣; 何 蓓; 梁 媛
宝鸡市中心医院神经外科,陕西宝鸡 721008
Author(s):
ZHU Feng; ZHANG Peng; SONG Jian-rong; HE Bei; LIANG Yuan
Department of Neurosurgery,Baoji Central Hospital,Shaanxi Baoji 721008,China
关键词:
内皮素受体A;  动脉瘤性蛛网膜下腔出血;  迟发性脑血管痉挛;  基因多态性
分类号:
R743.9; Q786
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 探讨动脉瘤性蛛网膜下腔出血(aSAH)后迟发性脑血管痉挛(DCVS)与内皮素受体A(EDNRA)基因rs5335多态性的关系。方法 选择2015年1月～2017年1月在宝鸡市中心医院神经外科治疗的133例aSAH患者纳入研究,按照是否并发DCVS分为DCVS组78例和对照组55例,采用聚合酶链反应-限制性片段长度多态性法检测EDNRA基因rs5335位点多态性。结果 DCVS组和对照组基因型分布均符合Hardy-Weinberg遗传平衡(χ2=0.295,P=0.863; χ2=0.652,P=0.722)。在等位基因模型和显性基因模型下,DCVS组和对照组比较,rs5335位点等位基因、基因型分布频率差异均具有统计学意义(χ2=4.213,P=0.040; χ2=4.790,P=0.029),隐性基因模型下两组基因型差异无统计学意义(χ2=1.299,P=0.254)。多因素Logistic回归法分析结果显示对于aSAH患者,携带等位基因C可降低DCVS发生风险(OR=0.572,95% CI 0.401～0.872,P=0.021)。结论 EDNRA基因rs5335位点多态性与aSAH患者发生DCVS相关。
Abstract:
Abstract:Objective To investigate the genetic association between endothelin receptor type A(EDNRA)gene polymorphism and delayed cerebral vasospasm(DCVS)in patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods 133 aSAH patients from January 2015 to January2017 were recruited to participate in the study.According to whether combined with DCVS,they were divided into the DCVS group(78 cases)and the control group(55 cases).Genotype was determined by polymerase chain reaction- restrictionfragment length polymorphism combined with DNA direct sequencing technique for the polymorphism of the EDNRA gene.Results Samples of DCVS group and control group both were consistent with Hardy-Weinberg's law of inheritance(χ2=0.295,P=0.863; χ2=0.652,P=0.722).There were significant differences of EDNRA gene rs5335 polymorphism between DCVS group and control group,under allele model(χ2=4.213,P=0.040)and the dominant model(χ2=4.790,P=0.029).However,there was no difference of EDNRA gene polymorphism between DCVS group and control group under recessive model(χ2=1.299,P=0.254).Multivariate Logistic regression analysis showed that allele C was protective factor of DCVS for aSAH patients(OR=0.572,95%CI 0.401～0.872,P=0.021).Conclusion For aSAH patients,EDNRA gene rs5335 polymorphism may closely related to DCVS.

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备注/Memo

备注/Memo:
作者简介:朱 峰(1981-),男,大学本科学历,主治医师,研究方向:神经疾病临床研究治疗,E-mail:zhufeng198102@163.com。
更新日期/Last Update: 2017-12-26