[1]唐元艳,张利铭,张江召,等.骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析[J].现代检验医学杂志,2017,32(06):71-73.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　TANG Yuan-yan,ZHANG Li-ming,ZHANG Jiang-zhao,et al.Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients[J].Journal of Modern Laboratory Medicine,2017,32(06):71-73.[doi:10.3969/j.issn.1671-7414.2017.06.001]
点击复制

骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
71-73
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients
文章编号:
1671-7414(2017)06-071-03
作者:
唐元艳; 张利铭; 张江召; 熊 涛; 梁 艳; 余卓君; 刘荟敏; 刘 敏; 黄知平
华中科技大学同济医学院附属荆州医院血液内科,湖北荆州 434020
Author(s):
TANG Yuan-yan; ZHANG Li-ming; ZHANG Jiang-zhao; XIONG Tao;  LIANG Yan; YU Zhuo-jun; LIU Hui-min; LIU Min; HUANG Zhi-ping
Department of Hematology,Jingzhou Hospital Affilited to TongjiMedical College of Huazhong University of Science and Technology,Hubei Jingzhou 434020,China
关键词:
骨髓增生异常综合征;  发育异常;  荧光原味杂交
分类号:
R551.3; R446.113
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 总结分析骨髓增生异常综合征患者(MDS)细胞形态学异常与染色体异常的相关性。方法 回顾性分析82例MDS患者完整的病例资料,探讨MDS细胞形态学异常与FISH检测染色体异常的相关性。结果 82例MDS患者中,染色体异常45例,+8为出现频率最高的染色体异常,其中单纯+8异常8例,-5和5q-各6例、20q- 7例、-7和7q-各5例、复杂核型(>3种异常)6例、+8伴20q- 1例,5q-伴20q- 1例。核型异常组与核型正常组之间原始细胞比例、幼红细胞巨幼样变及核畸形、巨核细胞系发育异常(单圆核巨核细胞、多圆核巨核细胞、小巨核细胞)比例差异有统计学意义(P<0.05)。高危组与低危组间、低危组与中危组间核型异常比例差异有统计学意义(P<0.05)。结论 MDS患者的染色体异常与形态学改变可能相关。
Abstract:
Abstract:Objective To investigate the correlation between morphological abnormalities and abnormal myelodysplastic syndromes(MDS)cloning.Methods 82 cases of MDS were collected with completeFISH and morphological abnormalities.The relationship between MDS cell morphology and chromosome abnormality was investigated.Results 45 cases of chromosomal abnormalities were found,and +8 were the most frequent chromosomal abnormalities.8 cases were +8,-5 and 5q- were 6,20q- were 7,-7and 7q- were 5,complex karyotypes(>3 abnormalities)were 6.There were statistically significant differences in the proportion of primordial cells,megakaryocyte dysplasia,megakaryocyte abnormalities between karyotype abnormal group andkaryotype normal group(P<0.05).There were statistically significant differences in the proportion of abnormal karyotype among high risk group and low risk group,the low risk group and medium risk group(P<0.05).Conclusion The chromosomal abnormalities of MDS patients would be relatedto morphological changes.

参考文献/References:

[1] Garcia-Manero G.Prognosis of myelodysplastic syndromes[J].Hematology Am Soc Hematol Educ Program,2010,2010(1):330-337.
[2] Kawankar N,Vundinti BR.Cytogenetic abnormalities in myelodysplastic syndrome:an overview[J].Hematology,2011,16(3):131-138.
[3] Arber DA,Orazi A,Hasserjian R,et al.The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia[J].Blood,2016,127(20):2391-2405.
[4] 肖志坚.骨髓增生异常综合征的精确诊断[J].中华血液学杂志,2015,36(5):361-362. Xiao ZJ.The precise diagnosis of myelodysplastic syndromes[J].Chin J Hematol,2015,36(5):361-362.
[5] 唐元艳,梁 艳,熊 涛,等.荧光原位杂交技术与细胞遗传学分析在骨髓增生异常综合征患者-5/5q和-7/7q-检测中的评价应用[J].现代检验医学杂志,2011,26(6):86-88. Tang YY,Liang Y,Xiong T,et al.Detection of -5/5q- and -7/7q-in myelodysplastic syndromes by fluorescence in situ hybridization and cytogenetic analysis[J].Journal of Modern Laboratory Medicine,2011,26(6):86-88.
[6] 韩秀蕊,杨娣娣,赵 园,等.281例骨髓增生异常综合征患者染色体核型分析及临床意义的研究[J].现代检验医学杂志,2015,30(4):91-92,95. Han XR,Yang DD,Zhao Y,et al.Study on chromosome karyotype and its clinical significance in 281 cases of myelodysplastic syndromes[J].Journalof Modern Laboratory Medicine,2015,30(4):91-92,95.
[7] Greenberg P,Cox C,LeBeau MM,et al.International scoring system for evaluating prognosis in myelodysplastic syndromes[J].Blood,1997,89(6):2079-2088.
[8] Voso MT,Fenu S,Latagliata R,et al.Revised international prognostic scoring system(IPSS)predicts survival and leukemic evolution of myelodysplasticsyndromes significantly better than IPSS and WHO prognostic scoring system:validation by the gruppo romano mielodisplasie italian regional database[J].J Clin Oncol,2013,31(21):2671-2677.
[9] Greenberg PL,Tuechler H,Schanz J,et al.Revised international prognostic scoring system for myelodysplastic syndromes[J].Blood,2012,120(12):2454-2465. 收稿日期:2017-07-12 修回日期:2017-07-30

相似文献/References:

[1]张宇洋,孙雪静.骨髓穿刺涂片联合骨髓活检切片在骨髓增生异常综合征诊断中的应用[J].现代检验医学杂志,2016,31(02):139.[doi:10.3969/j.issn.1671-7414.2016.02.042]
　ZHANG Yu-yang,SUN Xue-jing.Value of Both Bone Marrow Biopsy and Smear in Diagnosis of Myelodysplastic Syndrome[J].Journal of Modern Laboratory Medicine,2016,31(06):139.[doi:10.3969/j.issn.1671-7414.2016.02.042]
[2]韩秀蕊,杨娣娣,赵 园,等.281例骨髓增生异常综合征患者染色体核型分析及临床意义的研究[J].现代检验医学杂志,2015,30(04):91.[doi:10.3969/j.issn.1671-7414.2015.04.025]
　HAN Xiu-rui,YANG Di-di,ZHAO Yuan,et al.Study on Chromosome Karyotype and Its Clinical Significance in 281 Cases of Myelodysplastic Syndromes[J].Journal of Modern Laboratory Medicine,2015,30(06):91.[doi:10.3969/j.issn.1671-7414.2015.04.025]
[3]聂 群,陈卓诚a,聂李平a,等.自动血细胞分析参数对骨髓增生异常综合征和再生障碍性贫血的鉴别诊断价值[J].现代检验医学杂志,2017,32(05):74.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　NIE Qun,CHEN Zhuo-chenga,NIE Li-pinga,et al.Performance of Automatic Blood Cell Analysis Parameters for Differential Diagnosis of Myelodysplastic Syndromes and Aplastic Anemia[J].Journal of Modern Laboratory Medicine,2017,32(06):74.[doi:10.3969/j.issn.1671-7414.2017.05.017]
[4]张冬梅,万顺伦,于丽华.骨髓增生异常综合征患者外周血单个核细胞中OTC4，Gli1 基因的表达及与预后的COX 回归分析[J].现代检验医学杂志,2022,37(06):58.[doi:10.3969/j.issn.1671-7414.2022.06.011]
　ZHANG Dong-mei,WANG Shun-lun,YU Li-hua.Expression of OTC4 and Gli1 Genes in Peripheral Blood Mononuclear Cells of Patients with Myelodysplastic Syndrome and Their Correlation with Prognosis by COX Regression Analysis[J].Journal of Modern Laboratory Medicine,2022,37(06):58.[doi:10.3969/j.issn.1671-7414.2022.06.011]
[5]张良子,左琴琴,吴大洲,等.1 例骨髓增生异常综合征多次受血患者血清存在抗-M，抗-cE 和抗-Jkb 抗体的鉴定及配血输血策略[J].现代检验医学杂志,2023,38(01):195.[doi:10.3969/j.issn.1671-7414.2023.01.037]
　ZHANG Liang-zi,ZUO Qin-qin,WU Da-zhou,et al.Identification and Transfusion Strategy of Anti-M，Anti-cE and Anti-Jkb Antibodies in the Serum of Patients with Myelodysplastic Syndromes Receiving Multiple Blood Transfusions[J].Journal of Modern Laboratory Medicine,2023,38(06):195.[doi:10.3969/j.issn.1671-7414.2023.01.037]
[6]曲志梅,董 伟,刘艳萍.维奈克拉增强MDS 细胞系对地西他滨化疗敏感性机制的实验研究[J].现代检验医学杂志,2023,38(03):53.[doi:10.3969/j.issn.1671-7414.2023.03.010]
　QU Zhi-mei,DONG Wei,LIU Yan-ping.Experimental Study on the Mechanism of Venetoclax Enhancing the Sensitivity of MDS Cell Lines to Decitabine Chemotherapy[J].Journal of Modern Laboratory Medicine,2023,38(06):53.[doi:10.3969/j.issn.1671-7414.2023.03.010]
[7]徐 娟a,贲海祥a,丁琳琳a,等.白细胞介素-1β 基因（rs16944）单核苷酸多态性与骨髓增生异常综合征易感性及临床特征的相关性研究[J].现代检验医学杂志,2023,38(04):51.[doi:10.3969/j.issn.1671-7414.2023.04.009]
　XU Juana,BEN Haixianga,DING Linlina,et al.Study on the Relationship between Single Nucleotide Polymorphism of Interleukin-1β (rs16944) Gene and Susceptibility and Clinical Characteristics of Myelodysplastic Syndromes[J].Journal of Modern Laboratory Medicine,2023,38(06):51.[doi:10.3969/j.issn.1671-7414.2023.04.009]
[8]杨艳敏,郝秀君,赵志芳,等.骨髓增生异常综合征患者骨髓中ABAT mRNA表达和ABAT甲基化水平对预后预测价值研究[J].现代检验医学杂志,2024,39(06):84.[doi:10.3969/j.issn.1671-7414.2024.06.014]
　YANG Yanmin,HAO Xiujun,ZHAO Zhifang,et al.Prognostic Value of ABAT mRNA Expression and ABAT Methylation Level in Bone Marrow of Patients with Myelodysplastic Syndrome[J].Journal of Modern Laboratory Medicine,2024,39(06):84.[doi:10.3969/j.issn.1671-7414.2024.06.014]

备注/Memo

备注/Memo:
作者简介:唐元艳(1980-),女,副主任医师,主要从事血液病规范化诊疗,E-mail:huangsir8@126.com。
更新日期/Last Update: 2017-12-26