[1]许 娜a,刘永霞a,高莉莉a,等.肝硬化细菌感染患者血清中Presepsin检测的临床意义[J].现代检验医学杂志,2017,32(06):92-95.[doi:10.3969/j.issn.1671-7414.2017.06.001]
 XU Naa,LIU Yong-xiaa,GAO Li-lia,et al.Clinical Value of Presepsin in the Diagnosis and Prognosis of Bacterial Infection in Cirrhosis[J].Journal of Modern Laboratory Medicine,2017,32(06):92-95.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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肝硬化细菌感染患者血清中Presepsin检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
92-95
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Clinical Value of Presepsin in the Diagnosis and Prognosis of Bacterial Infection in Cirrhosis
文章编号:
1671-7414(2017)06-092-04
作者:
许 娜a刘永霞a高莉莉a王兴宁b
延安大学附属医院a.输血科; b.检验科,陕西延安 716000
Author(s):
XU NaaLIU Yong-xiaaGAO Li-liaWANG Xing-ningb
a.Department of Blood Transfusion; b.Department of Clinical Laboratory, Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China
关键词:
Presepsin 肝硬化 细菌感染 检测
分类号:
R575.2; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 观察和探讨肝硬化细菌感染患者血presepsin水平的变化对疾病检测的临床意义。方法 选取30例肝硬化细菌感染患者作为研究组,同期选取60例非感染肝硬化患者作为对照组。比较两组患者临床资料和血presepsin水平的差异; 对比研究组存活与死亡患者血presepsin水平; 应用COX多因素分析肝硬化细菌感染的预后危险因素; 比较PCT,CRP与presepsin检测灵敏度及特异度。结果 研究组患者血presepsin水平为1 002.3(575.1~2 149.5)pg/ml,对照组患者血presepsin水平为475.0(332.7~680.2)pg/ml,研究组患者血presepsin水平显著高于对照组,差异有统计学意义(t=1.865,P<0.05)。研究组死亡患者血presepsin水平显著高于存活患者(t=5.875,P<0.05); COX多因素分析显示presepsin水平是影响肝硬化细菌感染患者预后的独立危险因素。presepsin与CRP检测肝硬化细菌感染灵敏度和特异度相比,差异有统计学意义(P<0.05)。结论 血清presepsin水平可以作为预测肝硬化细菌感染新的生物标记物,其水平明显升高可作为判断肝硬化细菌感染的一项重要指标,值得临床加以关注。
Abstract:
Abstract:Objective To observe and evaluate the clinicalvalue of presepsin level in cirrhosis-associated bacterial infections.Methods 30 cirrhosis patients with bacterial infections were enrolled as study group.At admission,60 cirrhosis patients without bacterial infections were enrolled as control group.The difference of blood presepsin level between two groups were analyszed and compared the relationship between level of presepsin patients.The level of presepsin of survival and death group were compared and analyszed risk factors for the prognosis of bacterial infection by COXmulti-factor analysis.The sensitivity and specificity were compared by PCT,CRP and presepsin detection.Results The blood presepsin level of study group was 1 002.3(575.1 2~149.5)pg/ml,the blood presepsin level of control group was 475.0(332.7~680.2)pg/ml.The presepsin of study group was significantly higher than control group,the difference was statisticallysignificant(t=1.865,P<0.05).The presepsin level of death patients wassignificantly higher than survival patients(t=5.875,P<0.05).COX multi-factor analysis showed that presepsin levels were independent risk factors affecting the prognosis of bacterial infection in patients with liver cirrhosis.There were statistically significant of sensitivity and specific degrees between presepsin and CRP(P<0.05).Conclusion Presepsin levelis a valuable new biomarker for defining severe infections in cirrhosis.The increase of Presepsin level can be used as a judgment is an important index indicator of liver cirrhosis bacterial infection.It was worthy of clinical attention.

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备注/Memo

备注/Memo:
基金项目:陕西省延安市科技惠民计划,编号:2015HM-06-01。 作者简介:许 娜(1981-),女,本科,主管检验师,研究方向:临床免疫学检验,E-mail:xuna1981abc@163.com。 通讯作者:王兴宁,E-mail:ydfywxn@163.com。
更新日期/Last Update: 2017-12-26