[1]田 宇a,杨 超a,徐妍妍b,等.孕妇产后甲状腺炎患者血清中IL-6,IFN-γ,TNF-a,TPO-Ab含量检测的临床意义[J].现代检验医学杂志,2017,32(06):106-108,111.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　TIAN Yua,YANG Chaoa,XU Yan-yanb,et al.Clinical Significance of Detecting Serum IL-6,IFN-γ,TNF-α and TPO-Ab in Pregnant Women of Patients with Postpartum Thyroiditis[J].Journal of Modern Laboratory Medicine,2017,32(06):106-108,111.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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孕妇产后甲状腺炎患者血清中IL-6,IFN-γ,TNF-a,TPO-Ab含量检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
106-108,111
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Clinical Significance of Detecting Serum IL-6,IFN-γ,TNF-α and TPO-Ab in Pregnant Women of Patients with Postpartum Thyroiditis
文章编号:
1671-7414(2017)06-106-04
作者:
田 宇1; 2a; 杨 超2a; 徐妍妍2b; 王欢2b; 陈 葳1; 3
1.西安交通大学医学院,西安 710061; 2.西安医学院第一附属医院, 2a.检验科; 2b.产科,西安 710077; 3.西安交通大学医学院第一附属医院检验科,西安 710061
Author(s):
TIAN Yu1; 2a; YANG Chao2a; XU Yan-yan2b; WANG Huan2b; CHEN Wei1; 3
1.Xi'an Jiaotong University College of Medicine,Xi'an 710061,China; 2a.Department of Clinical Laboratory; 2b.Department of Obstetrics,the First Affiliated Hospital of Xi'an Medical University,Xi'an 710077,China; 3.Department of Clinical Laboratory, the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China
关键词:
炎性因子;  产后甲状腺炎;  白细胞介素-6;  肿瘤坏死因子;  干扰素
分类号:
R581.4; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 探讨孕妇产后甲状腺炎(postpartum thyroiditis,PPT)患者血清中白细胞介素6(IL-6)、干扰素γ(IFN-γ)、肿瘤坏死因子(TNF-α)和抗甲状腺过氧化物酶抗体(TPO-Ab)含量的临床意义。方法 选取2013年9月～2015年8月于西安医学院第一附属医院产科就诊的34例产后甲状腺炎患者和同期在该院进行健康体检的34例产妇作为研究对象。各清晨空腹抽取两管静脉血,依次使用放射免疫法测定甲状腺抗体(radioimmunologic assaycanti,thyrodid antibogy,RATA),ELISA双抗体夹心法检测两组实验对象IL-6,IFN-γ,TNF-α和TPO-Ab的浓度,对比两组的差异。结果 观察组IL-6,IFN-γ,TNF-α和TPO-Ab的结果分别为224.62±6.37 pg/ml,2.14±0.10 ng/ml,112.38±4.35 ng/ml,54.13±1.60 u/ml与对照组的82.07±5.58 pg/ml,0.92±0.05 ng/ml,36.78±1.74 ng/ml,14.02±2.14 u/ml相比,差异均有统计学意义(t=-98.154,-63.627,-94.090,-87.530,均P<0.05)。观察组IL-6,IFN-γ,TNF-α均与TPO-Ab呈正相关关系(RIL-6=0.852,RTNF-α=0.658,RIFN-γ=0.836)。结论 PPT患者的IL-6,IFN-γ,TNF-α和TPO-Ab浓度均明显增加,且前三者均与TPO-Ab浓度呈正相关关系。由此可推断三类炎性因子参与了PPT的发病,继而可以作为PPT患者诊断依据并为此类患者的治疗效果提供参考。
Abstract:
Abstract:Objective To investigate the serum of patientswith postpartum thyroiditis(Postpartum thyroiditis,PPT)in the serum of patients with interleukin 6(IL-6)and interferon gamma(IFN-γ)tumor necrosis factor(TNF-α)and anti thyroid peroxidase antibody(TPO-Ab)the clinical significance of detecting content.Methods 34 cases of postpartum thyroiditis were selected in the First Affiliated Hospital of Xi'an Medical University from September 2013 to August 2015.They were treated as the observation group,and selected 34 subjects for health check in the First Affiliated Hospital of Xi'an Medical College at the time as control group.Early in the morning,they all were taken 2 tube of verous blood on an emptystomach and separatedserum.Serum IL-6,INF-γ,TNF-α and TPO-Ab of the goups were detected with RATA and antibody sandwich ELISA,and the differences were compared between the two groups.Results Compared to healthy subjects of 3 kinds of cytokines and antibody levels in the blood of patients with PPT,the data were significantly higher and the difference was statistically significant(t=-98.154,-63.627,-94.090,P<0.05).The content correlated positively with the content of TPO-Ab between the 3 kinds of cytokines in blood ofPPT patients(RIL-6=0.852,RTNF-α=0.658.RIFN-γ=0.836).Conclusion Postpartum inflammatory factors and immune factors in the blood of patients with thyroiditis in secretion increased significantly,the content of TPO-Ab and the 3 factor was positively related to the pathogenesis of PPT,concluded that the 3 kinds of inflammatory factors are involved,so it can be used as basis for diagnosis of patients with PPT,and can provide reference for effective treatment.

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备注/Memo

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更新日期/Last Update: 2017-12-26