[1]朱文芳,韩 双,邹爱民,等.血清TBA,CG检测在妊娠期肝内胆汁淤积症早期诊断及围产儿不良结局影响的临床意义[J].现代检验医学杂志,2017,32(06):112-114.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　ZHU Wen-fang,HAN Shuang,ZOU Ai-min,et al.Clinical Significance of Detecting Serum TBA and CG in Early Diagnosis of Intrahepatic Cholestasis of Pregnancy and Perinatal Adverse Outcomes Influence[J].Journal of Modern Laboratory Medicine,2017,32(06):112-114.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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血清TBA,CG检测在妊娠期肝内胆汁淤积症早期诊断及围产儿不良结局影响的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
112-114
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Clinical Significance of Detecting Serum TBA and CG in Early Diagnosis of Intrahepatic Cholestasis of Pregnancy and Perinatal Adverse Outcomes Influence
文章编号:
1671-7414(2017)06-112-03
作者:
朱文芳; 韩 双; 邹爱民; 张 静; 熊丹锋
长安医院检验科,西安 710016
Author(s):
ZHU Wen-fang; HAN Shuang; ZOU Ai-min; ZHANG Jing; XIONG Dan-feng
Department of Clinical Laboratory,Chang'an Hospital,Xi'an 710016,China
关键词:
妊娠期肝内胆汁淤积症;  血清甘胆酸;  血清总胆汁酸;  围产儿结局
分类号:
R714.255; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 探讨血清总胆汁酸(TBA)、甘胆酸(CG)检测在妊娠期肝内胆汁淤积症(ICP)的早期诊断及围产儿不良结局的临床意义。方法 选取长安医院产科2015年6月～2017年6月诊治的ICP孕妇67例作为观察组,根据2015年《妊娠期肝内胆汁淤积症诊疗指南》的诊断标准分为轻度ICP组和重度ICP组,同时选择健康妊娠孕妇60例作为对照组。采用第五代循环酶法检测血清总胆汁酸(TBA)浓度,胶乳增强免疫比浊法检测血清甘胆酸(CG)浓度。比较各组血清TBA和CG检测结果以及结果异常率,同时比较各组间围产儿不良结局的发生率,评价血清TBA,CG检测对ICP的早期诊断及围产儿不良结局的临床价值。结果 血清TBA,CG检测结果在对照组、轻度ICP组、重度ICP组三组之间,差异均有统计学意义(F=267.13,201.09,均P<0.01),轻度ICP组血清TBA和CG检测结果高于对照组,差异有统计学意义(t=22.27,39.68,P<0.05),重度ICP组血清TBA,CG检测结果高于轻度ICP患者组,差异有统计学意义(t=10.24,70.87,P<0.05),且对照组、轻度ICP组、重度ICP组孕妇血清TBA,CG检测结果随着病情的加重而升高; 血清TBA,CG异常结果在60例对照组中均未检出,在67例ICP组(轻度ICP组和重度ICP组)分别为63例和61例,两组结果异常率比较,差异有统计学意义(χ2=29.35,31.27,P<0.01); 围产儿发生早产、胎儿窘迫、围产儿死亡及死胎的不良围产儿结局发生率在对照组、轻度ICP组、重度ICP组三组之间有明显差异(χ2=39.17,56.31,13.02,6.92,均P<0.01)。结论 ICP时,血清TBA和CG升高明显,可作为ICP诊断的敏感指标,提高ICP的检出率,并能有效预测围产儿结局,对ICP的早发现、早诊断具有重要的临床意义。
Abstract:
Abstract:Objective To investigate the clinical significance of serum total bile acid(TBA)and cholyglycine(CG)detection in the earlydiagnosis of intrahepatic cholestasis of pregnancy(ICP)and perinatal adverse outcomes.Methods Chose 67 cases of ICP pregnant women diagnosed and treated in Chang'an Hospital from June 2015 to June 2017 and they were selected as observation group.According to the 2015 edition of the diagnostic guidelines for the diagnosis and treatment of intrahepatic cholestasis of pregnancy.The patients were divided into mild ICP group and severe ICP group,and 60 healthy pregnant women were selected as the control group.The serum TBA concentration was measured by fifth generation cyclic enzyme method and the concentration of serum CG was detected by latex enhanced turbidimetric immunoassay.Theserum TBA,CG test results and the rate of abnormal test results,the incidencerate of perinatal adverse outcomes were compared between groups.Evaluation of serum TBA and CG detection of pregnancy early diagnosis of intrahepatic cholestasis and clinical value of perinatal adverse outcomes.Results The detection results of serum TBA and CG in the control group,mild ICP group and severe ICP group,there were significant differences between the three groups,the difference was statistically significant(P<0.01),the detectionresults in the CG group,serum TBA,ICP slightly higher than the control group,the difference was statistically significant(t=22.27,39.68,P<0.05).Weight of serum TBA and ICP group,the results of CG was higher than that of patients with mild ICP group,the difference was statistically significant(t=10.24,70.87,P<0.05).And in the control group,mild ICP group,severe ICP group pregnant women serum TBA,CG test results increased with the aggravation of the disease.Serum TBA and CG abnormal results in 60 cases of the control group were not detected.In 67 cases of group ICP(mild ICP group and severe ICP group)were 63 cases and 61 cases,two groups of abnormal results rate comparison,andthe difference was statistically significant(χ2=29.35, 31.27,P<0.01).Perinatal premature labor,fetal distress,perinatal death and stillbirth incidence of adverse perinatal outcomes in the control group,mild ICP group and severe ICP group were significantly different between the three groups(χ2=39.17,56.31,13.02,6.92,P<0.01).Conclusion Intrahepatic cholestasis of pregnancy,serum TBA and CG increased significantly,canbe used as a sensitive indicator of ICP diagnosis,improve the detection rate ofICP,and effectively predict perinatal outcome.For intrahepatic cholestasis ofpregnancy early detection and early diagnosis,it has important clinical significance.

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备注/Memo

备注/Memo:
作者简介:朱文芳(1976-),女,本科,主管检验师,研究方向临床生物化学检验,E-mail: qq15728784@sina.com。
更新日期/Last Update: 2017-12-26