[1]刘永玲a,罗厚龙b,刘行超b,等.血清SOD和hsCRP等指标在急性冠脉综合征中的应用及相关性分析[J].现代检验医学杂志,2017,32(06):115-117,121.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　LIU Yong-linga,LUO Hou-longb,LIU Xing-chaob,et al.Level and Correlationship of Serum SOD and hsCRP and Other Indicators in Acute Coronary Syndrome[J].Journal of Modern Laboratory Medicine,2017,32(06):115-117,121.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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血清SOD和hsCRP等指标在急性冠脉综合征中的应用及相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
115-117,121
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Level and Correlationship of Serum SOD and hsCRP and Other Indicators in Acute Coronary Syndrome
文章编号:
1671-7414(2017)06-118-04
作者:
刘永玲1a; 罗厚龙2; 1b; 刘行超1b; 赵静1b; 潘子湘1b; 农 妍1b
1.中国人民解放军第一八一医院 a.医务处; b.检验科,广西桂林 541002; 2.广东医科大学,广东湛江 524000
Author(s):
LIU Yong-ling1a; LUO Hou-long2; 1b; LIU Xing-chao1b; ZHAO Jing1b; PAN Zi-xiang1b; NONG Yan1b
1a.Medical Department; 1b.Department of Clinical Laboratory, the 181st Hospital of PLA,Guangxi Guilin 541002,China; 2.Guangdong Medical University,Guangdong Zhanjiang 524000,China
关键词:
急性冠脉综合征;  超氧化物歧化酶;  超敏C反应蛋白
分类号:
R541.4; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 探讨急性冠脉综合征(acute coronary syndrome,ACS)患者血清超氧化物歧化酶(superoxide dismutase,SOD)、超敏C反应蛋白(high-sensitive C-reactive protein,hsCRP)以及心肌损伤标志物之间的临床应用价值及其相关性。方法 采用病例对照研究,选择2015年1～12月入住解放军第一八一医院的ACS患者64例,同期因冠心病住院的非ACS患者(对照组)50例,检测患者血清SOD,hsCRP及心肌损伤标志物肌红蛋白(myoglobin, MYO)、心肌肌钙蛋白I(cardiac troponin I,cTnI)和肌酸激酶MB亚型(creatin kinase MB,CK-MB)。统计学分析采用t检验,Pearson相关分析。结果 ACS组SOD水平低于对照组(t=4.136,P<0.001),hsCRP,MYO,cTnI,CK和CK-MB水平明显高于对照组,差异均有统计学意义(t=-5.396,-3.495,-5.578,-4.655,-4.614; 均P<0.001)。ROC曲线分析SOD,hsCRP,MYO,cTnI,CK和CK-MB曲线下面积(area under curve,ROC AUC)分别为0.713,0.758,0.699,0.879,0.841和0.802。血清SOD与hsCRP,总胆固醇(total cholesterol,TC),低密度脂蛋白(low density lipoprotein,LDL-C)相关(r=-0.493,0.548,0.404,均P<0.01); 血清hsCRP与cTnI,三酰甘油(triglyceride,TG),SOD相关(r=0.671,-0.417,-0.493,均P<0.01)。结论 cTnI与hsCRP以及心肌损伤标志物呈正相关,hsCRP与SOD呈负相关,说明氧化应激、炎症刺激、血液脂质沉积在ACS的发生发展过程中均起到一定的作用。
Abstract:
Abstract:Objective To investigate the level of serum superoxide dismutase(SOD),high-sensitive C-reactive protein(hsCRP)and myocardial injury markers in acute coronary syndrome(ACS)and evaluate their relationship and diagnostic values.Methods Case control study was conducted.This studyenrolled 64 ACS patients and 50 non-ACS patients from the 181st Hospital of Chinese PLA in 2015.Serum SOD,hsCRP were tested and myocardial injury markers such as cardiac troponin I(cTnI),creatin kinase MB(CK-MB)were also tested.Student t test and Pearson test were used as statistical methods.Results Compared with control group,SOD of ACS group were significantlower(t=4.136,P<0.001)and hsCRP,Mb,cTnI,CK and CK-MB were significant higher(t=-5.396,-3.495,-5.578,-4.655 and -4.614,all P<0.001).The area under ROC curve of SOD,hsCRP,MYO,cTnI,CK and CK-MB was 0.713,0.758,0.699,0.879,0.841 and 0.802 respectively.After pearman test,the serum SOD were correlated to hsCRP,total cholesterol(TC)and low density lipoprotein(LDL-C)(r=-0.493,0.548 and 0.404,all P<0.01).Serum hsCRP was correlated to cTnI,triglyceride(TG)and SOD(r=0.671,-0.417 and -0.493,all P<0.01).Conclusion cTnI was positively correlated to hsCRP and markers of myocardial injury.hsCRP was negatively correlated with SOD.It implicated that oxidative stress,inflammatory response and serum lipid deposition may act an important role in the occurrence and development of ACS.

参考文献/References:

[1] 曾桂芬,徐宝灵,刘行超,等.血清心肌酶和超敏C反应蛋白联合检测在急性冠脉综合征诊断中的应用价值[J].中国老年学杂志,2017,37(5):1106-1108. Zeng GF,Xu BL,Liu XC,et al.The diagnosis value of combined detection of serum myocardial enzyme and high-sensitive C-reactive protein in acutecoronary syndrome[J].Chinese Journal of Gerontology, 2017,37(5):1106-1108.
[2] 罗厚龙,刘行超,谭秋培,等.急性冠状动脉综合征患者CysC,hs-CRP及Mb水平及相关性研究[J].检验医学与临床,2016,13(9):1156-1157,1160. Luo HL,Liu XC,Tan QP,et al.The level and correlationship of serum cystatin C,high-sensitive C-reactive protein and myoglobin in acute coronary syndrome patients[J].Lab Med Clin,2016,13(9): 1156-1157,1160.
[3] Vink A,Pasterkamp G.Atherosclerotic plaque burden,plaque vulnerabilityand arterial remodeling:the role of inflammation[J].Minerva Cardioangiol,2002,50(2):75-83.
[4] 万基伟,樊小农,王 舒,等.氧化应激与高血压发病机制研究[J].中医学报,2015(1):101-104. Wan JW,Fan XN,Wang S,et al.Research progress of relation betweenoxidative stress and hypertension[J].China Journal of Chinese Medicine,2015(1):101-104.
[5] Assadpoor-Piranfar M,Pordal AH,Beyranvand MR.Measurement of oxidizedlow-density lipoprotein and superoxide dismutase activity in patients with hypertension[J].Arch Iran Med,2009,12(2):116-120.
[6] Marti-Carvajal AJ,Sola I,Lathyris D.Homocysteine-lowering interventions for preventing cardiovascular events[J].Cochrane Database Syst Rev,2009,1(4):CD006612.
[7] Jensen MK,Wang Y,Rimm EB,et al.Fluorescent oxidation products and risk of coronary heart disease:a prospective study in women[J].J Am Heart Assoc,2013,2(5):e000195.
[8] Su X,He Y,Yang W,et al.Effect of danhong injection on PON1, SOD activity and MDA levels in elderly patients with coronary heart disease[J].Int JClin Exp Med,2014,7(12):5886-5889.
[9] 姚创利,黎 阳,鲁旭娟,等.超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系[J].现代检验医学杂志,2016,31(5):73-75. Yao CL,Li Y,Lu XJ,et al.Relationship of superoxide dismutase isoenzyme and high sensitive C-reactive protein with coronary heart disease[J].J Mod Lab Med,2016,31(5):73-75.
[10] 褚现明,李 冰,安 毅,等.炎症与动脉粥样硬化关系研究进展[J].中国分子心脏病学杂志,2010,11(3):184-188. Chu XM,Li B,An Y,et al.The progress of the relation between inflammation and atherosclerosis[J].Molecular Cardiology of China,2010,11(3):184-188.
[11] Abu-Farha M,Behbehani K,Elkum N.Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors andmetabolic syndrome in Arabs[J].Cardiovasc Diabetol,2014(13):76.
[12] Kuoppamaki M,Salminen M,Vahlberg T,et al.Hi-gh sensitive C-reactive protein(hsCRP),cardiovascular events and mortality in the aged:a prospective 9-year follow-up study[J].Arch Gerontol Geriatr,2015,60(1):112-117. 收稿日期:2016-12-09 修回日期:2017-07-20

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备注/Memo

备注/Memo:
作者简介:刘永玲(1986-),女,硕士,助理研究员,主要研究生化标志物的临床应用,E-mail:kxb 181@163.com。 通讯作者:农 妍,女,本科,主管技师,主要研究生化标志物的临床应用,E-mail:568430534@qq.com。
更新日期/Last Update: 2017-12-26