[1]刘 波a,张惠琴b,邹荣莉a.血清DBIL,TBIL,DBIL/TBIL检测在药物性肝损伤诊断中的应用[J].现代检验医学杂志,2017,32(06):151-153,159.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　LIU Boa,ZHANG Hui-qinb,ZOU Rong-lia.Application of Serum DBIL,TBIL,DBIL/TBI Detection in the Diagnosis of Drug-induced Liver Injury[J].Journal of Modern Laboratory Medicine,2017,32(06):151-153,159.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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血清DBIL,TBIL,DBIL/TBIL检测在药物性肝损伤诊断中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
151-153,159
栏目:
检验与临床
出版日期:
2017-12-25

文章信息/Info

Title:
Application of Serum DBIL,TBIL,DBIL/TBI Detection in the Diagnosis of Drug-induced Liver Injury
文章编号:
1671-7414(2017)06-151-04
作者:
刘 波a; 张惠琴b; 邹荣莉a
陕西省人民医院a.超声科; b.药剂科,西安 710068
Author(s):
LIU Boa; ZHANG Hui-qinb; ZOU Rong-lia
a.Department of Ultrasound; b.Department of Pharmacy,Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
药物性肝炎;  临床特点;  预测因素
分类号:
R575; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 分析血清直接胆红素(DBIL),总胆红素(TBIL),DBIL/TBIL检测在药物性肝损伤(DILI)诊断中的作用。方法 选择陕西省人民医院2014年1月～2016年12月期间住院药物性肝炎患者作为目标人群,回顾性分析临床资料及实验室结果,提取与转归有关指标进行单因素及多因素分析。结果 共有162例入组该研究,中药及中成药所致比例最高,约88例(54.3%),162例中肝细胞损伤型124例(76.5%),胆汁淤积型30例(18.5%),混合型8例(4.9%)。有效共120例(74.1%),未愈共41例(25.3%),死亡1例(0.6%)。黄疸,TBIL,DBIL,DBIL/TBIL作为未愈组独立预测因素。结论 DILI的最常见病因是中药,以肝细胞型最多见,患者是否进展为慢性DILI,与黄疸、TBIL,DBIL水平相关。
Abstract:
Abstract:Objective To analyze the functions of total bilirubin(TBIL)and direct bilirubin(DBIL),DBIL/TBIL detection in the diagnosisof drug-induced liver injury(DILI).Methods The clinical data and laboratory examination results of the patients with drug-induced liver disease in Shaanxi Provincial People's Hospital were collected from January2014 to December 2016.The factors were assessed by uni-variate and multivariate logistic regression analysis.Results In all,162 casesidentified as DILI were included in the study.The main causative group of drugs was Chinese herb(about 88 cases,54.3%).Among these 162 cases,124 cases(76.5%)were hepatocellular damage type,30 cases(18.5%)cholestatic damagetype and 8 cases(4.9%)mixed type damage.It showed that the complete recovery occurred in 120 patients(74.1%)and the non-recovery occurred in 41(25.3%),of which one death(0.6%).The binary logistic regression analysis identifiedthe jaundice,DBIL,TBIL and DBIL/TBIL as independent factors of the non-recovery of DILI.Conclusion The main causative group of drugswas Chinese herb and the hepatocellular damage type was the commonest one.What's more,whether the case progress into non-recovery one,was related to jaundice,TBIL,DBIL and DBIL/TBIL.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:刘 波(1982-),女,硕士,主治医师,研究方向:介入超声,E-mail:38170444@qq.com。 通讯作者:张惠琴(1964-),女,大专,主管药师,研究方向:医院药学,E-mail:zhq1589173@163.com。
更新日期/Last Update: 2017-12-26