[1]周晓艳,李 越,何 谦,等.不同基因型HCV感染患者血清Lpa水平检测分析[J].现代检验医学杂志,2018,33(01):49-51.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　ZHOU Xiao-yan,LI Yue,HE Qian,et al.Analysis of Serum Lp(a)Levels in Patients with Different Genotypes of HCV Infection[J].Journal of Modern Laboratory Medicine,2018,33(01):49-51.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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不同基因型HCV感染患者血清Lpa水平检测分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
49-51
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Analysis of Serum Lp(a)Levels in Patients with Different Genotypes of HCV Infection
文章编号:
1671-7414(2018)01-049-03
作者:
周晓艳; 李 越; 何 谦; 姬 婧; 刘佳丽; 薛 丽; 杨锐华
西安交通大学第二附属医院检验科,西安 710004
Author(s):
ZHOU Xiao-yan; LI Yue; HE Qian; JI Jing; LIU Jia-li; XUE li; YANG Rui-hua
Department of Clinical Laboratory, the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China
关键词:
脂蛋白a;  丙型肝炎病毒;  基因型
分类号:
R512.63; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 探讨丙型肝炎病毒感染患者不同基因型与血清脂蛋白(a)水平的相关性。方法 收集2016年6月～2017年6月在西安交通大学医学院第二附属医院就诊的105例HCV感染患者(男性59例,女性46例,平均年龄43.4±19.8岁)血清及同期健康对照患者30例血清标本和临床相关诊断资料,采用PCR-反向点杂交法检测HCV基因型分型,采用贝克曼AU5800全自动生化分析仪对其血清Lp(a)水平进行检测,两样本均数的比较采用t检验,多样本均数比较采用单因素方差分析。结果 在105例HCV感染患者中共检出5种亚型,其中1b基因型31例,2a基因型30例,3a基因型19例,3b基因型12例,6a基因型13例; HCV感染组的血清Lp(a)水平(10.87±6.21 mg/L)低于对照组(21.51±12.99 mg/L),差异有统计学意义(t=6.281,P<0.000 1); 3b,6a,2a,3a和1b五个基因型HCV感染患者的Lp(a)水平分别为12.51±6.11,9.75±5.73,12.28±7.63,9.22±4.47和10.37±5.75mg/L,均低于健康对照组,差异有统计学意义(t=2.288～4.355,均P<0.05); 各个基因型之间Lp(a)水平差异无统计学意义(F=1.091,P=0.365 4)。结论 与健康对照组相比,HCV感染能降低Lp(a)血清水平,且其在血清中表达水平与丙型肝炎的基因型不相关。
Abstract:
Abstract:Objective To investigate whether serum Lp(a)level was related to the different genotypes of hepatitis C virus.Methods The serum and corresponding clinical data of 105 patients(male: 59,female:46; average age:43.4±19.8)infected HCV and 30 healthy controls in the Second Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017 were collected.HCV genotypes was detected by PCR-reverse pointhybridization,all Lp(a)levels of serum were detected by using automatic biochemical analyzer AU5800 of Beckman.The comparison of the mean of the twosamples was applied with t-test,analysis of variance was appliedto compare among samples.Results There were 5 genotypesfound in 105 patients,including 31 patients with genotype 1b of HCV infection,30 patients with genotype 2a infection,19 patients with genotype 3a infection,12 patients with genotype 3b infection,13 patients with genotype 6a infection.The serum levels of Lp(a)in patients infected with HCV(10.87±6.21 mg/L)were significantly lower than that of healthy controls(21.51±12.99 mg/L),thedifference was statistically significant(t=6.281,P<0.000 1),meanwhile,the level of each genotype(3b,6a,2a,3a and 1b was 12.51±6.11,9.75±5.73,12.28±7.63,9.22±4.47和10.37±5.75 mg/L,respectively)was lower than that of healthy controls,respectively(t=4.355,3.356,3.965,2.288and 3.119,all P<0.05),and the difference among genotypes was no statistically significant (F=1.091,P=0.365 4).Conclusion Compared with healthy controls,HCV could reduce the expression of serum Lp(a),but the serum Lp(a)levels were not associated with the genotypes of HCV.

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备注/Memo

备注/Memo:
作者简介:周晓艳(1990-),女,硕士研究生,从事临床生化和免疫学研究,E-mail:xiaoyanzhou10@163.com。 通讯作者:何 谦(1971-),女,博士,主任技师,从事临床生化和免疫学研究,E-mail:qianh0511@163.com。
更新日期/Last Update: 2018-02-07