[1]苏 洋,梅秋雁.血浆NGAL,Cys C和尿NAG/Crea联合检测对早期糖尿病肾病诊断价值的研究[J].现代检验医学杂志,2018,33(01):99-101,106.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　SU Yang,MEI Qiu-yan.Study on Combined Determination Plasma NGAL,Cys C and Urinary NAG/Crea for the Diagnosis of Early Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2018,33(01):99-101,106.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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血浆NGAL,Cys C和尿NAG/Crea联合检测对早期糖尿病肾病诊断价值的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
99-101,106
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Study on Combined Determination Plasma NGAL,Cys C and Urinary NAG/Crea for the Diagnosis of Early Diabetic Nephropathy
文章编号:
1671-7414(2018)01-099-04
作者:
苏 洋; 梅秋雁
昆明医科大学第一附属医院检验科,昆明 650032
Author(s):
SU Yang; MEI Qiu-yan
Department of ClinicalLaboratory, the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China
关键词:
中性粒细胞明胶酶相关脂质运载蛋白;  半胱氨酸蛋白酶抑制剂C;  尿微量清蛋白与肌酐比;  尿N-乙酰-β-D-氨基葡萄糖苷酶与肌酐比;  早期糖尿病肾病
分类号:
R587.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 探讨血浆中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、半胱氨酸蛋白酶抑制剂C(Cys C)和尿N-乙酰-β-D-氨基葡萄糖苷酶与尿肌酐的比值(NAG/Crea)联合检测对早期糖尿病肾病的诊断价值。方法 收集2016年12月～2017年2月于昆明医科大学第一附属医院住院治疗的67例2型糖尿病患者,根据尿微量清蛋白与肌酐比(UALB/Crea)的值分为两组:糖尿病尿微量清蛋白正常组(UALB/Crea<30mg/gCrea)35例与早期糖尿病肾病组(即微量清蛋白尿组,UALB/Crea 30～300mg/gCrea)32例,另选择20例同期体检正常志愿者作为对照组,收集所有入组人员的临床资料,采用全自动生化分析仪检测其血浆NGAL,Cys C和尿NAG/Crea,并采用受试者工作特征(ROC)曲线对各检测指标进行分析。结果 ①早期糖尿病肾病患者血浆NGAL,Cys C和尿NAG/Crea明显高于对照组,差异有统计学意义(Z=-5.740～-5.386,P<0.05); ②患者血浆NGAL,Cys C和尿NAG/Crea的ROC曲线下面积较其他指标有明显优势,分别为0.858,0.911和0.714。结论 联合检测血浆NGAL,Cys C和尿NAG/Crea对于临床糖尿病肾病的早期诊断有较高价值。
Abstract:
Abstract:Objective To investigate the value of plasma neutrophil gelatinase-associated lipocalin(NGAL),cystatin C(Cys C)and the ratio of urinary N-acetyl-beta-D-glucosaminidase to creatinine(NAG/Crea)combined determination in the diagnosis of early diabetic nephropathy.Methods Collected 67 cases of patients with type 2 diabetes hospitalized in the First Affiliated Hospital of Kunming Medical University from December 2016 to February 2017.According to the value of UALB/Crea was divided into two groups:Diabetic urinary microalbumin normal group(UALB/Crea<30 mg/gCrea)had35 patients and early diabetic nephropathy group(namely the trace albuminuriagroup,UALB/Crea 30～300 mg/gCrea)had 32 patients.Other selected 20 normal volunteers as control group,compared with a medical group to gather all the staffof the clinical data,using automatic biochemical analyzer detected the plasmaNGAL,Cys C and urine NAG/Crea,and adopted the receiver-operating characteristic(ROC)curve of the detection index was analyzed.Results ①Plasma NGAL,Cys C and urinary NAG/Crea of diabetic nephropathy patients was significantly higher than those of healthy control group(Z=-5.740～-5.386,P<0.05).②The areaunder receiver operating characteristic(ROC)curve of plasma NGAL,Cys C and urine NAG/Crea were 0.858,0.911 and 0.714.Conclusion Plasma NGAL,Cys C and urinary NAG/Crea combined determination have a higher value for early diagnosis of diabetic nephropathy.

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备注/Memo

备注/Memo:
基金项目:云南省卫生系统领军人才项目(L-201202)。 作者简介:苏 洋(1988-),女,本科,检验师,主要从事临床化学检验工作,E-mail:393381385@qq.com。 通讯作者:梅秋雁(1987-),E-mail:494897341@qq.com。
更新日期/Last Update: 2018-02-07