[1]张维贞,向 丽,黄 山a,等.NT-ProBNP和cTnI联合检测对心律失常不同类型的鉴别诊断价值探讨[J].现代检验医学杂志,2018,33(01):102-105.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　ZHANG Wei-zhen,XIANG Li,HUANG Shana,et al.Differential Diagnosis Value of Combined Detection NT-ProBNP and cTnI for Different Types of Arrhythmia[J].Journal of Modern Laboratory Medicine,2018,33(01):102-105.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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NT-ProBNP和cTnI联合检测对心律失常不同类型的鉴别诊断价值探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
102-105
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Differential Diagnosis Value of Combined Detection NT-ProBNP and cTnI for Different Types of Arrhythmia
文章编号:
1671-7414(2018)01-102-04
作者:
张维贞1; 向 丽1; 黄 山2a; 田 野2b
1.贵州医科大学检验学院,贵阳 550001; 2.贵州省人民医院a.临床检验中心; b.心内科,贵阳 550002
Author(s):
ZHANG Wei-zhen1; XIANG Li1; HUANG Shan2a; TIAN Ye2b
1.Clinical Laboratory Medicine Department,Guizhou Medical University,Guiyang 550001,China; 2a.the Clinical Laboratory Center; 2b.Department of Cardiology,Guizhou Provincial People's Hospital,Guiyang 550002,China
关键词:
氨基端脑钠肽前体;  肌钙蛋白I;  心律失常;  诊断;  鉴别诊断
分类号:
R541.7; R446.11
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 探讨氨基端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)和肌钙蛋白I(cardiac troponin I,cTnI)对心律失常的诊断价值,以及对心律失常不同疾病类型之间的鉴别诊断价值。方法 收集2016年5月～2017年4月贵州省人民医院心内科确诊的114例心律失常住院患者血清作为疾病组,并选择同期体检的健康者108例作为对照组,以化学发光法检测NT-proBNP和cTnI血清水平。对所有资料进行正态性和方差齐性检验,采用t检验比较心律失常疾病组和对照组NT-proBNP和cTnI血清水平差异,采用单因素方差分析比较室性早搏、心房扑动、心房颤动和室性心动过速等不同疾病类型中NT-proBNP和cTnI血清水平差异。结果疾病组与对照组在性别与年龄上差异无统计学意义(t=0.24,1.47,P>0.05)。疾病组与对照组比较,血清NT-proBNP(855.96±101.46 pg/ml vs 369.77±194.88 pg/ml),cTnI(1.357±0.43 ng/ml vs 0.037±0.015 ng/ml)浓度均升高,且血清NT-proBNP,cTnI升高水平与健康对照组比较差异具有统计学意义(t=2.29,5.68,均P<0.05)。在室性早搏、心房扑动、心房颤动和室性心动过速等不同心律失常疾病类型中,心房扑动患者的NT-pro BNP血清水平(1 427.07 pg/ml)和室性心动过速患者cTnI(2.52ng/ml)血清水平最高,在四类疾病中NT-pro BNP和cTnI血清水平有着不同的分布差异(均P<0.05)。结论 NT-proBNP和cTnI血清水平对心律失常的诊断,以及心律失常不同疾病类型的鉴别,具有一定的参考价值。
Abstract:
Abstract:Objective To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide(NT-proBNP)and cardiac troponinI(cTnI)in cardiac arrhythmia.And the value of differential diagnosis between different types of arrhythmia.Methods The 114 patients with arrhythmia inpatients diagnosed were collected as the disease group and 108 healthy subjects were collected as the control group in Department of Cardiology,Guizhou Province People's Hospital from May 2016 to April 2017.The serum levels of NT-proBNP and cTnI were detected by chemiluminescence method.All the datawere tested for normality and homogeneity of variance.T test was usedto compare the serum levels of NT-proBNP and cTnI between patients with arrhythmia and control group.The level of serological differences of NT-ProBNP and cTnI in patients with ventricular premature beats,atrial flutter,atrial fibrillation and ventricular tachycardia were compared by One-way ANOVA.Results There was no significant differences in sex and age betweenthe disease group and the control group(t=0.24,1.47,all P> 0.05).Compared with the control group,the serum levels of NT-proBNP(855.96 ± 101.46 pg/ml vs 369.77 ± 194.88 pg/ml)and cTnI ± 0.43 ng/ml vs 0.037 ± 0.015 ng/ml)were increased,and the serum levels of NT-proBNP and cTnI were significantly higher than those in healthy control group(t=2.29,5.68,all P<0.05).The serum level of NT-pro BNP in atrial flutter patients(1 427.07pg / ml)and the serum level of cTnI(2.52 ng/ml)in ventricular tachycardia patients were the highest in premature ventricular contractions,atrial flutter, atrial fibrillation,ventricular tachycardia and other types of arrhythmia.There had different distribution(P<0.05)of NT-pro BNP and cTnI serum levelsamong the four kinds of diseases.Conclusion The serum levels of NT-pro BNP and cTnI have some reference value in the diagnosis of arrhythmia and in the differential diagnosis of different types of arrhythmia.

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备注/Memo

备注/Memo:
基金项目:贵州省科技厅社发公关项目,黔科合SY(2015)3045号。 作者简介:张维贞(1990-),女,硕士研究生,主要从事检验医学方法学与临床应用研究,E-mail:751356743@qq.com。 通讯作者:黄 山(1966-),男,大学本科,主任技师,主要从事检验医学方法学与临床应用研究,E-mail:huangshan263@sina.com。 田 野,男,硕士,主任医师,主要从事心血管内科临床与科研工作,E-mail:tianyemd@sina.com。共同通讯作者。
更新日期/Last Update: 2018-02-07