[1]高 硕,徐学静,王 森,等.免疫性血小板减少患者外周血Treg及Th1,Th2细胞检测及其临床意义[J].现代检验医学杂志,2018,33(01):112-114.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　GAO Shuo,XU Xue-jing,WANG Sen,et al.Detection and Clinical Significance of Treg and Th1,Th2 Cells in Peripheral Blood of Patients with Immune Thrombocytopenia[J].Journal of Modern Laboratory Medicine,2018,33(01):112-114.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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免疫性血小板减少患者外周血Treg及Th1,Th2细胞检测及其临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
112-114
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Detection and Clinical Significance of Treg and Th1,Th2 Cells in Peripheral Blood of Patients with Immune Thrombocytopenia
文章编号:
1671-7414(2018)01-112-03
作者:
高 硕; 徐学静; 王 森; 程 莉; 陈军浩; 孙 健
南京大学医学院附属鼓楼医院检验科,南京 210008
Author(s):
GAO Shuo; XU Xue-jing; WANG Sen; CHENG Li; CHEN Jun-hao; SUN Jian
Department of Medical Laboratory,the Drum Tower Hospital Affiliated to the Medical School of Nanjing University,Nanjing 210008,China
关键词:
免疫性血小板减少;  Treg;  Th1/Th2
分类号:
R558.2; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 研究免疫性血小板减少症(primary immune thrombocytopenia,ITP)患者外周血中CD4+CD25+FoxP3+细胞(Treg细胞)及Th1/Th2细胞水平并探讨其临床意义。方法 选取27例临床确诊ITP患者作为实验组,采用流式细胞术检测患者外周血Treg细胞及Th1/Th2细胞的比例,并与25例健康志愿者检测结果进行比较。结果 ITP患者外周血中Treg细胞比例为(2.20±0.93)%,健康对照组为(2.99±0.45)%,ITP患者组Treg细胞低于健康对照组(t=3.820,P<0.01); ITP患者组和健康对照组Th1/Th2细胞水平差异无统计学意义(tTh1=0.655,tTh2=0.467,均P>0.05)。结论 ITP患者外周血Treg细胞减少,其对ITP疾病发生发展的重要作用值得深入研究。
Abstract:
Abstract:Objective To detect the level of CD4+CD25+FoxP3+(Treg)and Th1,Th2 cells in peripheral blood of patients with immune thrombocytopenia and discuss its clinical significance.Methods Flow cytometry was used to detect the percentage of Treg cells and Th1,Th2 cells in peripheral blood of 27 patients with ITP.25 healthy volunteers were detected as control group.Results The percentage of Treg cellsin the peripheral blood of patients with ITP was(2.20±0.93)%,which significantly decreased compared with the healthy control group(2.99±0.45)%(t=3.820,P<0.01)respectively,and the levels of Th1,Th2 cells were not statistically different between the two groups(tTh1=0.655,tTh2=0.467,all P>0.05).Conclusion Treg cells in patients with ITP were decreased,and its important role in the development of ITP deserves further study.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:南京市医学科技发展资金(YKK15138)。 作者简介:高 硕(1987-),女,硕士,检验技师,主要研究方向:临床血液学检验,E-mail:shuoshuo65@163.com。 通讯作者:孙 健,副主任技师,E-mail:seine_med@163.com。
更新日期/Last Update: 2018-02-07