[1]汪照函,陈建勇,余志强,等.功能性便秘患者胃分泌功能改变的实验研究[J].现代检验医学杂志,2018,33(02):11-12,15.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　WANG Zhao-han,CHEN Jian-yong,YU Zhi-qiang,et al.Study on Altered Gastric Secretary Function in Patients with Functional Constipation[J].Journal of Modern Laboratory Medicine,2018,33(02):11-12,15.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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功能性便秘患者胃分泌功能改变的实验研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
11-12,15
栏目:
论著
出版日期:
2018-04-05

文章信息/Info

Title:
Study on Altered Gastric Secretary Function in Patients with Functional Constipation
文章编号:
1671-7414(2018)02-011-03
作者:
汪照函; 陈建勇; 余志强; 刘 晖; 罗 斌; 胡坚方
江西省人民医院消化内科,南昌 330006
Author(s):
WANG Zhao-han; CHEN Jian-yong; YU Zhi-qiang; LIU Hui; LUO Bin; HU Jian-fang
Department of Gastroenterology and Hepatology, Jiangxi Provincial People's Hospital,Nanchang 330006,China
关键词:
功能性便秘;  胃泌素17;  胃蛋白酶原Ⅰ;  胃蛋白酶原Ⅱ
分类号:
R574.62; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的: 了解功能性便秘患者胃分泌功能,明确有无胃肠轴激动。方法 研究纳入51例体检者为对照组,42例功能性便秘患者为便秘组,检测各组清晨胃液pH值、血清胃泌素17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平以及幽门螺杆菌感染比率并进行统计学分析。结果 对照组和便秘组患者Hp阳性率、PGⅡ水平差异无统计学意义(Hp阳性率:χ2=0.031,P=0.861; PGⅡ:t=1.666,P=0.100),两组间胃液pH值,G-17和PGⅠ水平差异具有统计学意义(pH值:t=2.180,P=0.032; G-17:t=2.703,P=0.008; PGⅠ:t=7.388,P<0.001)。结论 功能性便秘患者胃分泌功能亢进,提示功能性便秘患者可能存在胃肠分泌轴激动并促进胃酸分泌。
Abstract:
Abstract:Objective In order to detect gastric fluid pH value,Gastrin-17(G-17),pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PGⅡ)and figure out gastric secretory function in patients of functional constipation(FC).Methods 51 healthy individuals were chosen as control group and 42 patients with FC were chosen as FC group,of which serum gastric fluid pH value,Hp ratio,G-17,PGⅠand PGⅡ were detected and analyzed.Results Compared with control group,gastric fluid pH value were marked reduced(t=2.180,P=0.032),and G-17,PGⅠ level in bloodwere marked increased in FC group(G-17:t=2.703,P=0.008; PGⅠ:t=7.388,P<0.001).Hp ratio and blood level of PGⅡ in two groups showed no significant difference(Hp ratio:χ2=0.031,P=0.861; PGⅡ:t=1.666,P=0.100).Conclusion Increased gastric secretory function level were found in patients of functional constipation.It gave a hint that stimulated gastroenteritic axis existed in patients of functional constipation.

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备注/Memo

备注/Memo:
基金项目:江西省科技厅基金资助项目(20142BBG70094),名称:肝病患者肠源性内毒素血症发生机制的研究。江西省卫计委资助项目(20171002)名称:P120-catenin对急性肝衰竭大鼠肝组织及内皮炎症损伤的保护作用的研究。 作者简介:汪照函(1984-),男,医学博士,主治医师,主要从事消化内科临床及基础研究工作,E-mail:w43016472@163.com。 通讯作者:胡坚方(1959-),男,硕士生导师,主任医师,主要从事消化内科临床、基础及消化内镜研究工作,E-mail:hjf5513@126.com。
更新日期/Last Update: 2018-04-16