[1]晁满香,李建军,许昌泰,等.腰椎间盘突出症伴疼痛患者血清细胞因子的改变[J].现代检验医学杂志,2018,33(02):19-22.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　CHAO Man-xiang,LI Jian-jun,XU Chang-tai,et al.Changes of Serum Cytokines in Patients with Lumbar Intervertebral Disc Herniation and Pain[J].Journal of Modern Laboratory Medicine,2018,33(02):19-22.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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腰椎间盘突出症伴疼痛患者血清细胞因子的改变()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
19-22
栏目:
论著
出版日期:
2018-04-05

文章信息/Info

Title:
Changes of Serum Cytokines in Patients with Lumbar Intervertebral Disc Herniation and Pain
文章编号:
1671-7414(2018)02-019-04
作者:
晁满香1; 李建军1; 许昌泰2; 赵 钢3
1.解放军第323医院神经内科,西安 710054; 2.第四军医大学神经解剖学杂志编辑部, 西安 710032; 3.第四军医大学西京医院神经内科,西安 710032
Author(s):
CHAO Man-xiang1; LI Jian-jun1; XU Chang-tai2; ZHAO Gang3
1.Department of Neurology,the 323rd Hospital of the PLA,Xi'an 710054,China; 2.Editorial Office of Chinese Journal of Neuroanatomy,Fourth Military Medical University, Xi'an 710032,China; 3.Department of Neurology,Xijing Hospital, the Fourth Military Medical University,Xi'an 710032,China
关键词:
腰椎间盘突出症;  疼痛;  血清;  细胞因子
分类号:
R441.1; R446.1
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的 研究腰椎间盘突出症患者疼痛与血清细胞因子变化的关系,并讨论其临床意义。方法 选择解放军323医院2014年1月～2016年12月确诊的腰椎间盘突出症患者74例,男性45例,女性29例,年龄46.2±16.1岁,病程22.6±7.8个月。根据VAS疼痛评分为轻度37例,中度23例和重度14例。对照选择同期健康体检者30例,男性18例,女性12例,年龄45.3±15.8岁。全部研究对象于空腹抽取静脉血,采用放射免疫法测定丙二醇(MDA)、超氧化物歧化酶(SOD)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF),血栓素(TX)、内皮素(ET)、前列腺素E(PGE)和降钙素(CA)水平。结果经统计学分析。结果 与正常对照比较,腰椎间盘突出症血清细胞因子MDA,SOD,IL-6,TNF,TX,ET,PGE和CA均有不同程度升高(P<0.05～0.01)。VAS评估腰椎间盘突出症重度疼痛者明显高于中度或轻度疼痛(P<0.05～0,01)。经Logistic分析,这些血清细胞因子与腰椎间盘突出症疼痛密切相关(OR=2.415～4.127,95%CI=1.146～11.735,P<0.05)。结论 腰椎间盘突出患者多项血清细胞因子与其疼痛程度存在密切关系,提示血清中这些细胞因子在疼痛过程可能影响机体生化代谢。
Abstract:
Abstract:Objective To study the relationship between thepain of the patients with lumbar intervertebral disc herniation(LIDH)and thechanges of serum cytokine,and to discuss the clinical significance.Methods From January 2014 to December 2016,74 cases of LIDH diagnosed in the 323rd Hospital of the PLA were selected,including 45 males and 29 females,whose age was 46.2±16.1 years,and the duration 22.6±7.8 months.According to the VAS pain score,37 cases were mild,23 cases were moderate and 14cases were severe.The control was 30 cases of healthy physical examination in the same period,18 males and 12 females,age 45.3±15.8 years.All subjects were collected for venous blood on fasting.MDA,superoxide dismutase(SOD),interleukin -6(IL-6),tumor necrosis factor(TNF),thromboxane(TX),endothelin(ET),prostaglandin E(PGE)and calcitonin(CA)were all measured by radioimmunoassay.The results were analyzed statistically.Results Thecompared with normal control group,serum cytokines MDA,SOD,IL-6,TNF,TX,ET,PGE and CA increased in different degrees(P<0.05～0.01).The VAS assessment of severe pain in LIDH was significantly higher than that of moderate or mild pain(P<0.05～0.01).Logistic analysis showed that these serum cytokines were closely related to the pain of LIDH(OR=2.415～4.127,95%CI=1.146～11.735,P<0.05).Conclusion The serum cytokines in patients with LIDH are closely related to the degree of pain,suggesting that these cytokines in serum may affect biochemical metabolism in the process of pain.

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相似文献/References:

[1]赵英伦,马 元,莫 森,等.腰椎间盘突出症患者血清中Caspase-3和Caspase-9活性研究[J].现代检验医学杂志,2018,33(02):13.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　ZHAO Ying-Lun,MA Yuan,MO Sen,et al.Serum Caspase-3 and Caspase-9 Activity in Patients with Lubar Intervertebral Disc Protrusion[J].Journal of Modern Laboratory Medicine,2018,33(02):13.[doi:10.3969/j.issn.1671-7414.2018.02.001]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(N0.30770670)。 作者简介:晁满香(1976-),女,学士,主治医师,研究方向:神经内科疾病和疼痛诊治等,E-mail:xuct2008@qq.com。 通讯作者:许昌泰(1959-),男,硕士,教授,研究方向:医学编辑和医学情报,E-mail:xuct2001@qq.com。 赵 钢(1960-),男,博士,教授,研究方向:临床神经内科疾病诊治,E-mail:zhaogang@fmmu.edu.cn。
更新日期/Last Update: 2018-04-16