[1]张同庆,杨文东.急性脑梗死并发幽门螺旋杆菌感染者血脂水平及氧化应激反应的观察[J].现代检验医学杂志,2018,33(02):66-69.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　ZHANG Tong-qing,YANG Wen-dong.Observation of Serum Lipid Level and Oxidative Stress Response in Patients with Acute Cerebral Infarction Complicated with Helicobacter Pylori Infection[J].Journal of Modern Laboratory Medicine,2018,33(02):66-69.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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急性脑梗死并发幽门螺旋杆菌感染者血脂水平及氧化应激反应的观察()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
66-69
栏目:
论著
出版日期:
2018-04-05

文章信息/Info

Title:
Observation of Serum Lipid Level and Oxidative Stress Response in Patients with Acute Cerebral Infarction Complicated with Helicobacter Pylori Infection
文章编号:
1671-7414(2018)02-066-04
作者:
张同庆1; 杨文东2
1.德州市立医院检验科,山东德州 253000; 2.利津县第二人民医院检验科与病理科,山东东营 257447
Author(s):
ZHANG Tong-qing1; YANG Wen-dong2
1.Department of Clinical Laboratory, Dezhou Municiple Hospital,Shandong Dezhou 253000,China; 2.Department of Laboratory Medicine and Pathology,the Second People's Hospital of Lijin,Shandong Dongying 257447,China
关键词:
急性脑梗死;  幽门螺旋杆菌;  血脂;  氧化应激
分类号:
R743.33; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的 通过检测急性脑梗死(ACI)并发幽门螺旋杆菌(Hp)感染者血清血脂和丙二醛(MDA)水平及超氧化物歧化酶(SOD)活性,观察Hp感染对血脂代谢及氧化应激反应的影响。方法 选择ACI组350例和对照组80例,检测血清Hp-IgG抗体(胶体金法)和14C尿素呼气试验(14C-UBT),采用美国贝克曼库尔特AU680全自动生化分析仪检测血清血脂及SOD活性(比色法),采用上海现科752可见分光光度计(532 nm)检测血清MDA水平(TBA法)。结果 ACI组Hp感染率(69.5%)显著高于对照组(33.8%),差异有统计学意义(χ2=18.882,P<0.01)。Hp感染组与Hp非感染组比较,血清TC,TG,LDL-C及HDL-C水平差异均具有统计学意义(t=4.167～5.521,均P<0.01)。对照组、Hp非感染组及Hp感染组的血清MDA水平和SOD活性差异均具有统计学意义(F=34.891,46.613,均P<0.01)。Hp感染组与Hp非感染组血清MDA水平和SOD活性比较差异具有统计学意义(t=5.197,9.713,P<0.01),Hp非感染组与对照组比较差异也具有统计学意义(t=3.173,8.228,P<0.01)。结论 急性脑梗死并发幽门螺旋杆菌感染者,机体内血脂代谢紊乱加剧及氧化应激反应增强,此可能是幽门螺旋杆菌感染加剧急性脑梗死病情的原因之一。
Abstract:
Abstract:Objective To observe the Hp infection effect onblood lipid metabolism and oxidative stress through detecting acute cerebral infarction(ACI)with Helicobacter pylori(Hp)infection serum lipid and malondialdehyde(MDA)level and superoxide dismutase(SOD)activity.Methods Chose ACI 350 cases of ACI group,80 cases of control group and detected serum Hp-IgG antibody(by colloidal gold)and 14C urea breath test(by14C-UBT).Used the American beckman coulter AU680 fullautomatic biochemical analyzer to detect the serum lipid and SOD activity(colorimetry),and used Shanghai now 752 visible spectrophotometer(532 nm)to detect the serum MDAlevel(TBA).Results The Hp infection rate of ACI group(69.5%)was significantly higher than that in the control group(33.8%),the differences was statistically significant(χ2=18.882,P<0.01).The differences in serum TC,TG,LDL-C and HDL-C levels were statistically significant(t=4.167～5.521,all P<0.01)compared with Hp non-infection group.The serum MDA level and SOD activity of the control group and Hp infection groupwere statistically significant(F=34.891～46.613,all P<0.01).Hp infection with Hp infection group to compare serum MDA level and SOD activity differences statistically significant(t=5.197,9.713,all P<0.01),theHp infection group and control group in comparative differences were statistically significant(t=3.173,8.228,all P<0.01).ConclusionAcute cerebral infarction merger of HP infection,blood lipid metabolic disturbance in body increased and enhanced oxidative stress reaction,thismay be intensified HP infection is one of the reasons for acute brain infarctiondisease.

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备注/Memo

备注/Memo:
作者简介:张同庆(1965-),男,本科,副主任技师,主要从事临床检验学研究,E-mail:dytqzh@sina.com。 通讯作者:杨文东(1963-),男,本科,副主任技师,主要从事临床检验学与病理学研究,E-mail:yangwendong007@126.com。
更新日期/Last Update: 2018-04-16