[1]张 振,潘 晴,刘 旭,等.circRNA与肿瘤发生的研究进展[J].现代检验医学杂志,2018,33(02):157-159,164.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　ZHANG Zhen,PAN Qing,LIU Xu,et al.Research Progress of the Relationship between Circular RNA and Tumorigenesis[J].Journal of Modern Laboratory Medicine,2018,33(02):157-159,164.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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circRNA与肿瘤发生的研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
157-159,164
栏目:
综述
出版日期:
2018-04-05

文章信息/Info

Title:
Research Progress of the Relationship between Circular RNA and Tumorigenesis
文章编号:
1671-7414(2018)02-157-04
作者:
张 振; 潘 晴; 刘 旭; 李 芬
淮安市淮阴医院检验科,江苏淮安 223300
Author(s):
ZHANG Zhen; PAN Qing; LIU Xu; LI Fen
Department of Clinical Laboratory,Huaiyin Hospital of Huai'an City,Jiangsu Huai'an 223300,China
关键词:
环状RNA;  竞争性内源RNA;  肿瘤
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
环状RNA(Circular RNA,circRNA)是近年来发现的一种新的内源性非编码RNA。circRNA不具有5'末端帽子和3'末端多聚A尾,呈现闭合环状结构,这种特殊结构使circRNA具有高度的保守性和稳定性。circRNA主要由外显子形成,大量存在于真核细胞中。circRNA比线性的mRNA含有更丰富的转录本,能够在转录或转录后水平调控多种生命活动。而且,circRNA还可作为竞争性内源RNA(ceRNA)的组成部分,抑制miRNA的活性,从而调控基因转录、翻译等功能。作为一种新型调控分子及研究热点,circRNA在肿瘤等多种疾病中异常表达,有望成为新的诊断及预测肿瘤发生发展的生物标志物。
Abstract:
Abstract:Circular RNA(circRNA)is a special kind of newly confirmed noncoding RNA.CircRNA is a closed cyclic RNA molecule and lack of the 5' end cap and the 3' end of poly(A)tail structure,showing highly conservative and stability.CircRNA is mainly composed of exons,exists in a variety of eukaryotic cells.CircRNA are showed to be the most predominant transcripts compared with linear mRNAs,acting as regulators in transcription or post-transcription in almost all kingdoms of life.CircRNA function as competing endogenousRNA to inhibit miRNA activity,involving the regulation of gene transcription and translation.As a new regulatory molecules,circRNA has a dysregulated expression in different kinds of disease including tumor,and may be a newly marker fordiagnosis of tumors and prediction the progress of tumors.

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相似文献/References:

[1]张 振,李 芬.ceRNA与肿瘤[J].现代检验医学杂志,2016,31(04):128.[doi:10.3969/j.issn.1671-7414.2016.04.036]

备注/Memo

备注/Memo:
作者简介:张 振(1986-),男,硕士,检验师,专业:分子诊断学研究,E-mail:zzconquerer@163.com。 通讯作者:李 芬,E-mail:3063892835@qq.com。
更新日期/Last Update: 2018-04-16