[1]黄红波a,刘庚勋b.ALK阳性表达相关肿瘤临床病理学及靶向治疗研究进展[J].现代检验医学杂志,2018,33(02):160-164.[doi:10.3969/j.issn.1671-7414.2018.02.001]
 HUANG Hong-boa,LIU Geng-xunb.Advances in Clinicalpathology and Targeted Therapy of ALK-positive Expression Tumor[J].Journal of Modern Laboratory Medicine,2018,33(02):160-164.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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ALK阳性表达相关肿瘤临床病理学及靶向治疗研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
160-164
栏目:
综述
出版日期:
2018-04-05

文章信息/Info

Title:
Advances in Clinicalpathology and Targeted Therapy of ALK-positive Expression Tumor
文章编号:
1671-7414(2018)02-160-05
作者:
黄红波a刘庚勋b
解放军163中心医院a.影像科; b.病理科,长沙 410003
Author(s):
HUANG Hong-boaLIU Geng-xunb
a.Department of Medical Imaging; b.Department of Pathology,the 163th Hospital of PLA,Changsha 410003,China
关键词:
间变性淋巴瘤激酶 ALK肿瘤 靶向 治疗
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目前已发现多种实体瘤中存在间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)阳性表达,与肿瘤的发生发展及预后相关。正确诊断ALK阳性肿瘤和判断ALK阳性表达的亚细胞定位对ALK重排的类型、肿瘤的诊断、预后判断及指导ALK抑制剂的个体化精准治疗具有重要意义。该文主要围绕ALK阳性肿瘤的临床病理特点及靶向治疗现状进行介绍。
Abstract:
Abstract:It has been found that multiple solid tumors were positive for anaplastic lymphoma kinase(ALK)currently.ALK might be associated with the genesis,development and prognosis of tumor.It is important to localization accurately diagnose the tumor expressed ALK and the subcellular of positive expression of ALK to underway individual precise therapy on rearrangement type ofALK,diagnosis of carcinoma and prognosis and using of ALK inhibitor.This paper mainly reviews the clinicopathological features of ALK positive tumor and itstargeted treatment status.

参考文献/References:

[1] Morris SW,Kirstein MN,Valentine MB.Fusion of a kinase gene,ALK,to a nucleolar protein gene,NPM,in non-Hodgkin's lymphoma[J].Science,1994,263(5151):1281-1284.
[2] Cazzola M.Introduction to a review seties:The 2016 revision of the WHOclassification of tumors of bematopietic and lymphoid tissues[J].Blood,2016,127(20):2361-2364.
[3] Gorczynski A,Prelowska M,Adam P,et al.ALK-positive cancer:still a growing entity[J].Future Oncol,2014,10(2):305-321.
[4] Gascoyne RD,Lamant L,Martin-Subero JI,et al.ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements:report of6 cases[J].Blood,2003,102(7):2568-2573.
[5] Wass M,Behlendorf T,Schaedlich B,et al.Crizotinib in refractory ALK-positive large-cell lymphoma:a case report with a short-term response[J].Eur J Haematol,2014,92(3):268-270.
[6] Soda M,Choi YL,Enomoto M,et al.Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer[J].Nature,2007,448(7153):561-566.
[7] 曹培龙,王 凯,王鸿雁,等.ALK阳性非小细胞肺癌72例临床病理分析[J].临床与实验病理学杂志,2017,33(10):1092-1096. Cao PL,Wang K,Wang HY,et al.Non-small cell lung cancer with EML4-ALK positive expression:a clinicopathological analysis of 72 cases[J].J Clin Exp Pathol,2017,33(10):1092-1096.
[8] 黎谢梦丹,罗 凯,吴顺芳,等.华南地区非小细胞肺癌患者肿瘤组织EGFR,ALK和ROS1基因突变分析[J].现代检验医学杂志,2017,32(5):16-18,23. Lixie MD,Luo K,Wu SF,et al.Mutation analysis of EGFR,ALK and ROS1 in tumor tissues of patient with non-small cell lung cancer in South of China[J].Journal of Modern Laboratory Medicine,2017,32(5):16-18,23.
[9] National Comprehensive Cancer Network(NCCN).Clinical Practice Guidelinesin Oncology.Non-Small Cell Lung Cancer,Version 2,2017.
[10] Viala M,Brossau S,Planchard D,et al.Second generation ALK inhibitors in non-small cell lung cancer:systemic review[J].Bull Cancer,2015,102(4):381-389.
[11] Ou SH,Jannoe PA,Bartlett CH,et al.Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients withadvanced ALK-positive NSCLC[J].Ann Oancol,2014,25(2):415-422.
[12] Friboulet L,Li N,Kaiayama R,et al.The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung[J].Cancer Discov,2014,4(6):662-673.
[13] Kodama T,Tsukaguchi T,Yoshida M,et al.Selective ALK inbibitor alectinib with potent antitumor activity in models of crizotinib resistance[J].Cancer Lett,2014,351(2):215-221.
[14] Schulte JH,Schulte S,Heukamp LC,et al.Targeted therapy for neuroblastoma:ALK inhibitors[J].Klin Padiatr,2013,225(6):303-308.
[15] Shi H,Wei L,Sun L,et al.Prinary gastrie inflammatory myofibroblastictumor:a clinicopathologic and immunohistochemical study of 5 eases[J].Pathol Res pract,2010,206(5):287-291.
[16] Antonescu CR,Suurmeijer AJ,Zhang L,et al.Molecular characterizationof inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement[J].Am J Surg Pathol,2015,39(7):957-967.
[17] Butrynski JE,D'Adamo DH,Hornick JL,et al.Crizotinib in ALK-raerranged inflammatory myofibroblastic tumor[J].N Engl J Med,2010,363(18):1727-1733.
[18] Lamant L,Pulford D,Bischof D,et al.Expression of the ALK tyrosine kinase gene in neuroblastoma[J].2000,156(5):1711-1721.
[19] Wang M,Zhon C,Sun Q,et al.ALK amplification and protein expression prediet inferior prognosis in neuroblastoma[J].Exp Mol Pathol,2013,95(2):124-130.
[20] Busam KL,Kutzner H,Cerroni L,et al.Clinical and pathologic findingsof spitz nevi and atypical spitz tumors with ALK fusions[J].Am J Surg Pathol,2014,38(7):925-933.
[21] Lin E,Li L,Guan Y,et al.Exon array profiling detests EML4-ALK fusion in breast,colorectal,and non-small cell lung cancers[J].Mol Cancer Res,2009,7(9):1466-1476.
[22] Ren H,Tan ZP,Zhu X,et al.Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovrtion cancer[J].Cancer Res,2012,72(13):3312-3323.
[23] Lee C,Park JW,Suth JH,et al.ALK-Positive renal cell carcinoma in alarge serise of consecutively resected Korean renal cell carcinoma patients[J].Korean J Pathol,2013,47(5):452-457.
[24] Jazii FR,Najafi Z,Malekzadeh R,et al.Identification of squamous cellcarcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer[J].World Cancer Gastroenterol,2006,12(44):7104-7122.
[25] Murugan AK,Xing M.Anaplastic thyrorid cancers harbor novel oncogenic mutations of the ALK gene[J].Cancer Res,2011,71(13):4403-4411.
[26] Chou A,Fraser S,Toon CW,et al.A detailed clinicopathologie study ofALK-translocated papillary thyroid carcinoma[J].Am J Surg Pathol,2015,39(5):652-659.
[27] Kim SML,Kim MJ,Jung HA,et al.Presence of anaplastic lymphoma kinasetranslocation in sarcomatoid carcinoma of head and neck and treatment effect ofcrizotinib:A case series[J].Head Neek,2015,37(5):E66-E69.
[28] Chiarle R,Gong JZ,Guasparri I,et al.NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors[J].Blood,2003,101(5):1919-1927.
[29] 宋蓉蓉,任国平,刘晓燕,等.前列腺癌间变性淋巴瘤激酶基因改变与蛋白表达及其临床意义[J].中华病理学杂志,2015,44(6):382-385. Song RR,Ren GP,Liu XY,et al.Alterations of ALK gene and protein expression in prostatic cancer and its clinical significance[J].Chinese Journal Pathology,2015,44(6):382-385.
[30] 刘建化,金浩生,田红霞,等.HBsAg阳性肝癌患者预后及病理因素与ALK基因表达的相关性研究[J].中国病理生理杂志,2016,32(5):841-846. Liu JH,Jin HS,Tian HX,et al.Status and clinical siguificance of ALK gene expression in HBsAg-positive hepatocellular carcinoma patients[J].ChineseJournal of Pathophysiology,2016,32(5):841-846.

备注/Memo

备注/Memo:
作者简介:黄红波(1967-),男,本科,副主任医师,研究方向:肿瘤影像诊断,E-mail:453452372@qq.com。 通讯作者:刘庚勋(1967-),男,本科,副主任医师,主要从事常规病理和分子病理检测与诊断,E-mail:lgengxun@sina.com。
更新日期/Last Update: 2018-04-16