[1]凡瞿明,杜 琴,卢小岚,等.SLE患者外周血单核细胞CD36水平与血脂紊乱的关系[J].现代检验医学杂志,2018,33(03):50-53.[doi:10.3969/j.issn.1671-7414.2018.03.014]
　FAN Qu-ming,DU Qin,LU Xiao-lan,et al.Relationship between CD36 Expression on Peripheral Blood Monocytes and Dyslipidemia in SLE Patients[J].Journal of Modern Laboratory Medicine,2018,33(03):50-53.[doi:10.3969/j.issn.1671-7414.2018.03.014]
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SLE患者外周血单核细胞CD36水平与血脂紊乱的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年03期
页码:
50-53
栏目:
论著
出版日期:
2018-07-17

文章信息/Info

Title:
Relationship between CD36 Expression on Peripheral Blood Monocytes and Dyslipidemia in SLE Patients
文章编号:
1671-7414(2018)03-050-04
作者:
凡瞿明1; 3; 杜 琴1; 3; 卢小岚1; 3; 王强2; 3; 汪光蓉2; 3; 王东生1; 3; 蔡艳娟1; 邓仁兵1; 刘 萍4; 张国元1; 3
1.川北医学院附属医院检验科,四川南充 637000; 2.川北医学院检验系,四川南充 637000; 3.川北医学院转化医学研究中心,四川南充 637000; 4.博奥赛斯天津生物科技有限公司,天津 300300
Author(s):
FAN Qu-ming1; 3; DU Qin1; 3; LU Xiao-lan1; 3; WANG Qiang2; 3; WANG Guang-rong2; 3;  WANG Dong-sheng1; 3; CAI Yan-juan1; DENG Ren-bing1; LIU Ping4; ZHANG Guo-yuan1; 3
1.Department of Clinical Laboratory,Affiliated Hospital of North Sichuan Medical College, Sichuan Nanchong 637000,China; 2.Faculty of Clinical Laboratory,North Sichuan Medical College,Sichuan Nanchong 637000,China; 3.Translational MedicineResearch Center, North Sichuan Medical College,Sichuan Nanchong 637000,China; 4.Bioscience Biotechnology Co.,LTD,Tientsin,Tianjin 300300,China
关键词:
系统性红斑狼疮;  单核细胞;  簇分化抗原36;  脂蛋白
分类号:
R593.241; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.03.014
文献标志码:
A
摘要:
目的 通过检测系统性红斑狼疮(systemic lupus erythematosus,SLE)患者及表观健康自愿者外周血单核细胞CD36的表达及其血清脂蛋白水平,探讨SLE患者单核细胞CD36表达对脂代谢的影响,为临床早期提示SLE并发心血管疾病风险提供依据。方法 利用流式细胞仪检测SLE患者30例和健康体检者31例外周血单核细胞CD36强度,采用生化仪测定血清脂蛋白水平,统计分析患者与健康对照组间单核细胞CD36表达平均荧光强度与血清脂蛋白浓度差异性,及SLE患者CD36与脂蛋白间的相关性。结果 SLE患者单核细胞CD36表达低于健康对照组(|Z|=4.198,P=0.000),TG,VLDLC和apoB100高于对照组(|Z|=4.603,P=0.000; |Z|=3.620,P=0.001; |Z|=2.208,P=0.027),HDLC与apoA1低于对照组(|Z|=3.751,P=0.000; |Z|=3.918,P=0.000),差异均有统计学意义; TC和LDLC在两组间差异无统计学意义(|Z|=0.159,P=0.874; |Z|=0.476,P=0.634)。SLE患者单核细胞CD36表达强度与血清脂蛋白水平无显著相关性(P>0.05)。结论 系统性红斑狼疮患者外周血单核细胞CD36表达相较健康人群降低,其可能是SLE心血管疾病高发的独立风险因素。
Abstract:
Abstract:Objective To explore the relationship between expression level of CD36 on peripheral monocytes and dyslipidemia,and evaluatethe clinical significance in prediction risk of cardiovascular disease in patients with systemic lupus erythematosus(SLE).Methods Monocytes CD36 and serum lipoprotein levels were determined in 30 patients with SLE and 31 cases healthy volunteers.Compared CD36 of monocytes expression intensityand lipoprotein concentration in SLE patients and health controls.Meanwhile,the correlation between CD36 and lipoprotein was analyzed in SLE patients.Results The CD36 expression on monocytes in patients with SLE was significantly lower than that in the control group(|Z|=4.198,P=0.000).TG,VLDLC and apoB100 levels of SLE patients were significantly higher than the control group(|Z|=4.603,P=0.000.|Z|=3.620,P=0.001.|Z|=2.208,P=0.027).HDLC and apoA1 levels of SLE patients were significantly lower than thecontrol group(|Z|=3.751,P=0.000.|Z|=3.918,P=0.000).There were no statistically significant difference in TC and LDLC between SLE patients and healthy volunteers(|Z|=0.159,0.476,P=0.874,0.634).There was no significant correlation between CD36 expression intensity and serum lipoprotein levels in SLE patients(P>0.05).Conclusion The expression of CD36 on peripheral blood monocytes of patients with SLE was lower than that ofhealthy people,and the decrease of CD36 expression on monocytes may be an independent risk factor for cardiovascular disease in SLE.

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备注/Memo

备注/Memo:
基金项目:国家科技支撑计划项目,编号:2015BAK45B01。 作者简介:凡瞿明(1971-),男,学士,副教授,研究方向:临床免疫学检验与应用开发,E-mail: fanquming@126.com。 通讯作者:张国元(1965-),男,学士,教授,E-mail:13508099826@163.com。
更新日期/Last Update: 2018-04-16