[1]侯光华,冯 斌,王俊妨,等.特应性皮炎患者结膜囊细菌分布及药敏分析[J].现代检验医学杂志,2018,33(03):151-153.[doi:10.3969/j.issn.1671-7414.2018.03.039]
　HOU Guang-hua,FENG Bin,WANG Jun-fang,et al.Study on the Drug Sensitivity and Distribution of Conjunctival Sac Bacteria in Patients with Atopic Dermatitis[J].Journal of Modern Laboratory Medicine,2018,33(03):151-153.[doi:10.3969/j.issn.1671-7414.2018.03.039]
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特应性皮炎患者结膜囊细菌分布及药敏分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年03期
页码:
151-153
栏目:
检验与临床
出版日期:
2018-07-17

文章信息/Info

Title:
Study on the Drug Sensitivity and Distribution of Conjunctival Sac Bacteria in Patients with Atopic Dermatitis
文章编号:
1671-7414(2018)03-151-03
作者:
侯光华1; 冯 斌2; 王俊妨1; 马文江1
1.天津医科大学眼科医院,天津 300384; 2.天津医科大学总医院,天津 300070
Author(s):
HOU Guang-hua1; FENG Bin2; WANG Jun-fang1; MA Wen-jiang1
1.Ophthalmological Hospital Affiliated to Tianjin Medical University,Tianjin 300384,China; 2.Tianjin Medical University General Hospital,Tianjin 300070,China
关键词:
结膜囊;  细菌;  特应性皮炎;  眼内炎;  耐甲氧西林金黄色葡萄球菌
分类号:
R753; R446.5
DOI:
10.3969/j.issn.1671-7414.2018.03.039
文献标志码:
A
摘要:
目的 分析特应性皮炎(atopic dermatitis,AD)患者结膜囊细菌分布特征,并进行药敏分析,为AD患者行内眼手术围手术期眼内炎预防措施提供依据。方法 研究采集30例AD患者结膜囊拭子标本,进行细菌培养鉴定,并进行药物敏感试验,另外采集30例正常患者标本作为对照。结果 结膜囊菌培养,对照组结膜囊细菌阳性检出率为56.67%,AD组为86.67%(χ2=6.538,P=0.110); 对照组金黄色葡萄球菌检出率为10.00%,AD组为70.00%,两组比较差异有统计学意义(χ2=22.125,P<0.001); 对照组耐甲氧西林金黄色葡萄球菌(methicillin resistant staphylococcus aureus,MRSA)检出率为3.33%,AD组为40.00%,两组比较差异有统计学意义(χ2=11.684,P=0.001)。药敏分析中,除两组革兰染色阳性球菌对万古霉素敏感率都为100%外,AD组革兰染色阳性球菌对左氧氟沙星、庆大霉素和头孢唑啉的敏感率均低于对照组,两组比较差异均有统计学意义(χ2=4.367,6.440,4.063; P=0.037,0.011,0.044)。结论 AD组结膜囊金黄色葡萄球菌、MRSA检查率均高于正常对照组,并且AD组革兰染色阳性球菌对一些抗菌素敏感率降低,此类患者进行内眼手术时围手术期眼内炎防控措施应加强。
Abstract:
Abstract:Objective To analyze the drug susceptibility and the distribution of conjunctival sac bacterial in patients with atopic dermatitis(AD),and provide evidence for the endophthalmitis prevention measures in perioperative eye surgery.Methods The conjunctival sac swabs of 30 patients with atopic dermatitis were collected for bacterial culture identification and drug susceptibility testing.30 specimens of normal patients were also collected as controls.Results Conjunctival sac specimens were cultured in bacteria.The positive rate of bacteria was 56.67% inthe control group and 86.67% in the AD group(χ2=6.538,P=0.110).Thepositive rate of the Staphylococcus aureus was 10.00% in the control groupand 70.00% in the AD group.The difference between the two groups was statistically significant(χ2=22.125,P<0.001).The positive rate of methicillin-resistant Staphylococcus aureus(MRSA)was 3.33% in the control groupand 40.00% in the AD group.The difference between the two groups was statistically significant(χ2=11.684,P=0.001).In drug susceptibility analysis,the sensitivity rate of Gram-positive cocci to vancomycin was 100% in both groups.The sensitivity of gram-positive cocci to levofloxacin,gentamycin and cefazolin in the AD group was lower than that in the control group.The differences between the two groups were statistically significant(χ2= 4.367,6.440,4.063; P= 0.037,0.011,0.044).Conclusion The positiverates of Staphylococcus aureus and MRSA were higher in AD patients than in the control group.Gram-staining positive cocci in the AD group were lesssensitive to some antibiotics.When AD patients underwent intraocular surgery,perioperative endophthalmitis prevention and control measures should be strengthened.

参考文献/References:

[1] Werfel T,Schwerk N,Hansen G,et al.The diagnosis and graded therapy of atopic dermatitis[J].Dtsch Arztebl Int,2014,111(29/30):509-520.
[2] 张云凤,高芸璐,王秀丽,等.特应性皮炎伴白内障1例[J].中国皮肤性病学杂志,2016,30(6):650-651. Zhang YF,Gao YL,Wang XL,et al.One case of atopic dermatitis withcataract[J].The Chinese Journal of Dermatovenereology,2016,30(6):650-651.
[3] Fasciani R,Agresta A,Caristia A,et al.Methicllin-resistant Staphylococcus aureus ocular infection after corneal cross-linking for keratoconus:potential association with atopic dermatitis[J].Case Rep Ophthalmol Med,2015,2015:613273.
[4] Luo WX,Xu WD,Xia L,et al.Family-based whole exome sequencing of atopic dermatitis complicated with cataracts[J].Oncotarget,2017,8(35):59446-59454.
[5] 韦 祝,刘向宇,罗勇奇,等.特应性皮炎患者皮损部位的金黄色葡萄球菌定植情况及药敏分析[J].药物流行病学杂志,2016,25(6):350-353. Wei Z,Liu XY,Luo YQ,et al.Staphylococcus atreus colonizationin the skin lesions of patients with atopic dermatitis and its drug sensitivityanalysis[J].Chin J Pharmacoepidemiol,2016,25(6):350-353.
[6] 姬爱华,王广新,史传奎,等.苦参洗剂对儿童特应性皮炎皮损定植金黄色葡萄球菌影响的体内外研究[J].遵义医学院学报,2017,40(6):641-645. Ji AH,Wang GX,Shi CK,et al.Impact of anti-inflammatory sophoramoisturizing lotion on Staphylococcus aureus atopic dermatitis in children:in vitro and in vivo researches[J].Journal of Zunyi Medical University,2017,40(6):641-645.
[7] 何 侦,林陈娟,李俊宁,等.预防白内障手术后感染的术中应对策略探讨[J].实用防盲技术,2017,12(2):53-57. He Z,Lin CJ,Li JN,et al.Investigation on the intraoperative strategies to prevent postoperative infection in cataract surgery[J].Journal of Practical Preventing Bind,2017,12(2):53-57.
[8] Tyson SL,Bailey R,Roman JS,et al.Clinical outco-mes after injectionof a compounded pharmaceutical for prophylaxis after cataract surgery:a large-scale review[J].Curr Opin Ophthalmol,2017,28(1):73-80.
[9] 龙巧燕,陈青山,成洪波,等.白内障术后感染性眼内炎的临床特点及治疗[J].中华实验和临床感染病杂志(电子版),2017,11(3):265-268. Long QY,Chen QS,Cheng HB,et al.Clinical characteristics and treatment of infective endophthalmitis after cataract surgery[J].Chin J Exp ClinInfect Dis(Electronic Edition),2017,11(3):265-268.
[10] Blaiewicz I,Jas kiewicz M,Bauer M,et al.Decolonization of Staphylococcus aureus in patients with atopic dermatitis:a reason for increasing resistance to antibiotics[J].Postepy Dermatol Alergol,2017,34(6):553-560.
[11] Nakatsuji T,Chen TH,Narala S,et al.Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient inatopic dermatitis[J].Science Translational Medicine,2017,9(378):pii:eaah4680.
[12] 王 昕,李 荔,计紫超,等.393例眼内炎病原菌药敏结果及临床用药分析[J].临床药物治疗杂志,2017,15(8):38-41. Wang X,Li L,Ji ZC,et al.Analysis of drug sensitivity of pathogenic bacteria and medication selection in 393 cases of endophthalmitis[J].Clinical Medication Journal,2017,15(8):38-41.
[13] Wong IT,Tsuyuki RT,Cresswell-melville A,et al.Guidelines for the management of atopic dermatitis(eczema)for pharmacists[J].Can Pharm J(Ott),2017,150(5):285-297.
[14] Nowicki R,Trzeciak M,Wilkowska A,et al.Atopic dermatitis:current treatment guidelines.Statement of the experts of the Dermatological Section,Polish Society of Allergology,and the Allergology Section,Polish Society of Dermatology[J].Postepy Dermatol Alergol,2015,32(4):239-249.

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备注/Memo

备注/Memo:
作者简介:侯光华(1979-),女,大学本科,主管技师,主要从事临床微生物检验及感染性眼病实验室诊断研究,E-mail:jiayinini@hotmail.com。 通讯作者:马文江(1974-),男,研究生,副主任技师,主要从事感染性眼病实验室诊断研究及临床微生物学检验工作,E-mail:mwj707@sohu.com。
更新日期/Last Update: 2018-04-16