[1]赵娟,毛达勇.糖尿病血管病变患者血清补体C1q和B因子检测的临床意义[J].现代检验医学杂志,2018,33(04):98-99/103.[doi:10.3969/j.issn.1671-7414.2018.04.026]
　ZHAO Juan,MAO Da-yong.Clinical Significance of Detecting Serum Complement C1q and Factor B in Patients with Type 2 Diabetic Vascular Disease[J].Journal of Modern Laboratory Medicine,2018,33(04):98-99/103.[doi:10.3969/j.issn.1671-7414.2018.04.026]
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糖尿病血管病变患者血清补体C1q和B因子检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
98-99/103
栏目:
论著
出版日期:
2018-08-30

文章信息/Info

Title:
Clinical Significance of Detecting Serum Complement C1q and Factor B in Patients with Type 2 Diabetic Vascular Disease
文章编号:
1671-7414(2018)04-098-03
作者:
赵娟; 毛达勇
湖北省十堰市太和医院/湖北医药学院附属医院,湖北十堰 442000
Author(s):
ZHAO Juan; MAO Da-yong
Taihe Hospital of Shiyan, Affiliated to Hubei University of Medicine,Hubei Shiyan 442000,China
关键词:
糖尿病血管病变;  补体C1q;  B因子
分类号:
R587.2; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.04.026
文献标志码:
A
摘要:
目的 测定2型糖尿病血管病变患者血清补体C1q(C1q)和B因子(BF)的水平,分析C1q和BF与糖尿病血管病变患者的相关性。方法 透射免疫比浊法测定155例2型糖尿病血管病变患者、133例单纯性2型糖尿病患者(T2DM)和150例正常对照组的血清C1q和BF水平,并测定各组的生化指标:血糖(Glu)、糖化血红蛋白(HbA1c)、三酰甘油(TG)和总胆固醇(TC),做统计分析。结果 糖尿病血管病变组与T2DM组、对照组比较,C1q和BF均升高,差异有统计学意义(P<0.01),糖尿病血管病变组和T2DM组与对照组比较,C1q和BF均升高,差异有统计学意义(P<0.01); C1q和BF均与Glu,HbA1c,TG,TC呈正相关(C1q:r=0.35,0.40,0.34,0.36; BF:r=0.29,0.38,0.28,0.26)。结论 血清C1q和BF在T2DM及其血管病变的发生和发展过程中可能起重要作用。
Abstract:
Abstract:Objective To investigate the changes and relationship of the level of serum complement C1q(C1q)and factor B(BF)in patientswith type 2 diabetes mellitus(T2DM)with vascular disease.MethodsThe concentrations of C1q and BF in serum were investigated with transmission immune turbidimetric method.The biochemical indexes include blood glucose(Glu),glycosylated hemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC)were measured with colorimetric method in 155 cases of type 2 diabetes with vascular disease,133 cases of type 2 diabetes without any complications(T2DM),and 150 cases of normal control group.Analyzed the statistical parametersand correlations among the groups.Results Compared withthe T2DM and the control groups,both C1q and BF were significantly increased(P<0.01)in type 2 diabetic vascular disease.Compared with the control group,both C1q and BF were significantly increased(P<0.01)in T2DM.C1q and BF were positively correlated to Glu,HbA1c,TG and TC(C1q:r=0.35,0.40,0.34,0.36; BF:r=0.29,0.38,0.28,0.26).Conclusion Serum C1q and BF may played important roles in the occurrence and development of T2BM and its vascular disease.

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备注/Memo

备注/Memo:
作者简介:赵 娟(1975-),女,本科,副主任护师,研究方向:内科疾病护理学,E-mail:810670866@qq.com。 通讯作者:毛达勇(1969-),男,本科,副教授,主任技师,研究方向:2型糖尿病慢性并发症分子生物学机制的研究,E-mail:380067290@qq.com。
更新日期/Last Update: 2018-08-16