[1]吴剑锋.复发性自然流产患者血浆D-二聚体、抗凝血酶Ⅲ和蛋白C检测的临床意义[J].现代检验医学杂志,2018,33(04):112-114.[doi:10.3969/j.issn.1671-7414.2018.04.030]
　WU Jian-feng.Detection and Analysis of D-Dimer,Antithrombin Ⅲ and Protein C in Patients with Recurrent Spontaneous Abortion[J].Journal of Modern Laboratory Medicine,2018,33(04):112-114.[doi:10.3969/j.issn.1671-7414.2018.04.030]
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复发性自然流产患者血浆D-二聚体、抗凝血酶Ⅲ和蛋白C检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
112-114
栏目:
论著
出版日期:
2018-08-30

文章信息/Info

Title:
Detection and Analysis of D-Dimer,Antithrombin Ⅲ and Protein C in Patients with Recurrent Spontaneous Abortion
文章编号:
1671-7414(2018)04-112-03
作者:
吴剑锋
佛山市南海区妇幼保健院检验科,广东佛山528200
Author(s):
WU Jian-feng
Department of Clinical Laboratory, Nanhai Maternity and Child Health Care Hospital of Foshan,Guangdong Foshan 528200,China
关键词:
复发性自然流产;  D-二聚体;  抗凝血酶Ⅲ;  蛋白C
分类号:
R714.21; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.04.030
文献标志码:
A
摘要:
目的 探讨复发性自然流产(RSA)患者孕早期的D-二聚体(D-Dimer)、抗凝血酶Ⅲ(AT-Ⅲ)和蛋白C(PC)变化的临床意义。方法 选取150例有RSA病史且早孕的患者作为RSA组,其中根据流产的次数分为RSAⅠ组94例(流产次数2～3次)和RSAⅡ组56例(流产次数≥4次),另外选择100例健康且无流产史的早孕孕妇作为正常早孕组。对上述各组患者进行D-Dimer,AT-Ⅲ和PC的检测和对比分析。结果 RSA组和正常早孕组的D-Dimer,AT-Ⅲ和PC的结果分别为1.67±0.35 mg/L vs 0.37±0.29 mg/L,(84.57±10.88)% vs(99.28±9.01)%和(82.63±11.32)% vs(100.26±10.61)%,差异均有统计学意义(t=8.21,7.87,7.97,均P<0.01); RSAⅡ组和RSAⅠ组上述各参数比较结果分别为(1.84±0.31)mg/L vs(1.53±0.37)mg/L,(80.48±9.87)% vs(88.62±11.23)%和(79.89±11.64)% vs(86.77±12.78)%,差异均有统计学意义(t=3.86,4.31,4.50,均P<0.05)。结论 RSA患者在孕早期血栓形成的风险比正常孕妇高,且与既往的流产次数有一定的相关,D-Dimer,AT-Ⅲ和PC的检测对RSA患者血栓状态的筛查和改善妊娠结局有重要的临床意义。
Abstract:
Abastract:Objective To investigate the changes of D-Dimer(D-Dimer),antithrombin III(AT- III)and protein C(PC)in the early pregnancy of recurrent spontaneous abortion(RSA).Methods A total of 100 patients with a history of RSA and early pregnancy patients as RSA group,according to the number of miscarriages were divided into RSA group Ⅰ 64cases(abortion 2～3 times)and RSA Ⅱ Group 36 cases(abortion more than 4 times),another 100 healthy pregnant and no history of abortion as a normal pregnancygroup.Detection and analysis of D-Dimer,AT-Ⅲ and PC in all the above groups were done.Results The results of D-Dimer,AT-Ⅲ andPC in group RSA and normal pregnancy group were(1.67+0.35)mg/L vs(0.37+0.29)mg/L,(84.57+10.88)% vs(99.28+9.01)% and(82.63+11.32)% vs(100.26+10.61)% respectively,and the difference was statistically significant(t=8.21,7.87,7.97,all P<0.01).The results of the above parameters in group RSA Ⅱ and RSA Ⅰ were(1.84+0.31)mg/L vs(1.53+0.37)mg/L,(80.48+9.87)% vs(88.62+11.23)% and(79.89+11.64)% vs(86.77+12.78)% respectively,and the differences were statistically significant(t=3.86,4.31,4.50,all P<0.05).Conclusion The risk of thrombosis in RSApatients was higher than that of normal pregnant women in early pregnancy,andhad a certain correlation with the number of previous abortions.The detection of D-Dimer,AT-Ⅲ and PC has important parturient value for screening RSA patients and improving pregnancy outcomes.

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备注/Memo

备注/Memo:
作者简介:吴剑锋(1984-),男,大学本科,医学检验主管技师,主要从事出凝血方面研究,E-mail:9093361@qq.com。
更新日期/Last Update: 2018-08-16