[1]郭长青,曹玉亭,杨学文.血清淀粉样蛋白A检测对成年人群早期预测流感疫苗接种效果探讨[J].现代检验医学杂志,2018,33(04):140-143.[doi:10.3969/j.issn.1671-7414.2018.04.039]
　GUO Chang-qing,CAO Yu-ting,YANG Xue-wen.Study on the Effect of Serum Amyloid A Test on Early Influenza Vaccination in Adult Population[J].Journal of Modern Laboratory Medicine,2018,33(04):140-143.[doi:10.3969/j.issn.1671-7414.2018.04.039]
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血清淀粉样蛋白A检测对成年人群早期预测流感疫苗接种效果探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
140-143
栏目:
检验与临床
出版日期:
2018-08-30

文章信息/Info

Title:
Study on the Effect of Serum Amyloid A Test on Early Influenza Vaccination in Adult Population
文章编号:
1671-7414(2018)04-140-04
作者:
郭长青1; 曹玉亭2; 杨学文1
1.江苏省中医院检验科,南京 210029; 2.南湖社区卫生服务中心检验科,南京 210017
Author(s):
GUO Chang-qing1; CAO Yu-ting2; YANG Xue-wen1
1.Department of Clinical Laboratory,Jiangsu Provincial Hospital of TCM,Nanjing 210029,China; 2.Department of Clinical Laboratory,Nanhu Community Health Service Center,Nanjing 210017,China
关键词:
流感疫苗;  血清淀粉样蛋白A;  抗体效价
分类号:
R186.3; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.04.039
文献标志码:
A
摘要:
目的 探讨成人接种流感疫苗后血清淀粉样蛋白A(SAA)的变化及SAA对接种效果的预测意义。方法 选取南京市南湖社区卫生服务中心2016～2017年45例受试者并分为三组,每组15人,分别接受甲型流感疫苗注射、乙型丙型流感联合疫苗注射、甲型乙型丙型流感三联疫苗注射,并于疫苗注射前、注射后6 h、注射后24 h三个时间点抽取静脉血检测SAA; 疫苗注射后2周后抽血测流感抗体效价,分别与6 h及24 h SAA进行相关性分析。结果 疫苗注射后6,24 h三组间SAA变化水平差异无统计学意义(P>0.05); 疫苗注射2周后各受试者相应流感抗体效价与疫苗注射后6 h内SAA变化水平无线性相关,与疫苗注射后24 h内SAA变化水平呈线性相关。结论 SAA可作为成年人群流感疫苗注射效果的标志物,在短时间内预测注射效果。
Abstract:
Abstract:Objective To investigate the changes of serumamyloid protein A(SAA)after influenza vaccination in adults and the predictivesignificance of SAA on the inoculation effect.Methods From 2016 to 2017,45 subjects from Nanjing Nanhu Community Health Service Centerwere selected and divided into three groups,each group of 15 people,respectively,to accept A flu vaccine,B and C combined vaccine,A,B and C combined vaccine,at three time points:before the vaccination,6 hours after injection,24 hours after injection,extract venous blood serum for amyloid A measurement.Theantibody titer was detected by 2 weeks after injection,and the correlation between serum amyloid A and influenza antibody titer was analyzed.Results There was no significant difference in SAA levels between the 6h and 24h groups after the injection(P>0.05).There was no linear correlationbetween the corresponding influenza antibody titer after 2 weeks of vaccine injection and SAA change level in 6h,which was linearly correlated with the changelevel of SAA in 24h.Conclusion SAA can be used as a marker for the efficacy of influenza vaccination in adults,and can predict the efficacy of influenza vaccination in a short period of time.

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备注/Memo

备注/Memo:
作者简介:郭长青(1983-),男,大学本科,主管检验师,主要研究方向:临检、生化、免疫,E-mail:chgl-gcq@126.com。
更新日期/Last Update: 2018-08-16