[1]梁培松,王结珍,王伟佳,等.广东省中山地区孕中期产前筛查血清标志物中位数方程的建立[J].现代检验医学杂志,2018,33(05):46-48+52.[doi:10.3969/j.issn.1671-7414.2018.05.013]
　LIANG Pei-song,WANG Jie-zhen,WANG Wei-jia,et al.Establishment of the Median Equation of Prenatal Screening Serum Marker of the Second Trimester in Zhongshan of Guangdong Province[J].Journal of Modern Laboratory Medicine,2018,33(05):46-48+52.[doi:10.3969/j.issn.1671-7414.2018.05.013]
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广东省中山地区孕中期产前筛查血清标志物中位数方程的建立()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
46-48+52
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Establishment of the Median Equation of Prenatal Screening Serum Marker of the Second Trimester in Zhongshan of Guangdong Province
文章编号:
1671-7414(2018)05-046-04
作者:
梁培松; 王结珍; 王伟佳; 陈 康; 卢建强
中山大学附属中山医院检验医学中心,广东中山 528403
Author(s):
LIANG Pei-song; WANG Jie-zhen; WANG Wei-jia; CHEN Kang; LU Jiang-qiang
Department of Clinical Laboratory,the Affiliated Sun Yat-sen Hospital of Sun Yat-sen University,Guangdong Zhongshan 528403,China
关键词:
孕中期;  产前筛查;  甲胎蛋白;  人绒毛膜促性腺激素;  游离雌三醇;  中位数
分类号:
R715.3; R446
DOI:
10.3969/j.issn.1671-7414.2018.05.013
文献标志码:
A
摘要:
目的 探讨中山地区孕妇孕中期产前筛查血清标志物中位数方程的建立。方法 采用德国SIEMENS公司生产的IMMULITE2000全自动化学发光免疫分析系统对11 779例105～146孕天妇女进行甲胎蛋白、人绒毛膜促性腺激素、游离雌三醇(AFP,HCG,uE3)浓度检测; 采用SPSS19.0软件进行统计分析,采用spearman相关分析法分析孕龄、体重及年龄与AFP,HCG和uE3浓度的相关性; 采用加权回归分析法,构建中山地区血清标志物中位数曲线方程及体重校正曲线方程; 采用配对t检验进行中山地区数据与Prisca4风险评估软件内置数据进行比较。结果 体重与AFP,HCG,uE3呈低度相关; 孕龄与AFP/HCG/uE3呈中度相关; 中山地区的AFP,HCG,uE3浓度中位数与软件内置数据差异有统计学意义; 中山地区的AFP-MOM,HCG-MOM和uE3-MOM体重校正中位数与软件内置数据差异有统计学意义; 中山地区人群模型所得AFP-mMOM,HCG-mMOM和uE3-mMOM值更接近1。结论 建立中山地区孕中期孕妇的血清标志物中位数方程及体重校正方程是产前筛查实验室质量控制的保证,势在必行。
Abstract:
Objective To study and establish the median equation of prenatal screening serum marker of the second trimester in Zhongshan region.Methods Used IMMULITE2000 automatic chemiluminescence immunoassay system to detect the concentration of alpha-fetoprotein,humanchorionic gonadotropin and unconjugated estriol 3(AFP,HCG,uE3)of 11 779 cases women with pregnant 105～146 days.Used SPSS19.0 software to analyze all thedata.Used the spearman correlation analysis to analyze the correlation of age,weight and gestational age with the concentration of AFP,HCG and uE3.Using the weighted regression analysis method to establish the serum marker median equation and the weight calibration equation of Zhongshan,and using paired t test to compare the data of Zhongshan with the built-in data of the Prisca4 riskevaluation's software.Results Weight and AFP,HCG and uE3 concentration were appeared low correlation.Gestational age and AFP,HCG anduE3 were appeared moderate correlation.The difference of the median of AFP,HCG,uE3 concentration of Zhongshan and the software built-in data was statistically significant.The difference of the weight corrected median of AFP-MOM,HCG-MOM and u3-MOM of Zhongshan and the software built-in data was statisticallysignificant.The AFP-mMOM,HCG-mMOM and uE3-mMOM of the crowd model in Zhongshan were closer to 1.Conclusion To establish the medianequation and the weight correction equation of the prenatal screening serum marker of the second trimester pregnant women in Zhongshan region is the guaranteeof prenatal screening laboratory quality control and imperative.

参考文献/References:

[1] 邬玲仟,张 学.医学遗传学[M].北京:人民卫生出版社,2016:97-105.
Wu LQ,Zhang X.Medical Genetics[M].Beijing:People's Medical Publishing House,2016:97-105.
[2] Duan Y,Li Y,Xue Q.Serological prenatal screening and diagnosis for Down's syndrome[J].Clinical and Experimental Obstetrics & Gynecology,2014(41)5:572-574.
[3] 姜淑芳,符玉荣,马 莹,等.9 033例孕中期血清学筛查唐氏综合征模拟调整结果分析[J].解放军医学杂志,2017,42(4):342-346.
Jiang SF,Fu YR,Ma Y,et al.Simulati analysis of 9 033 cases of secnd trimester maternal serum screening for Down's syndrome[J].Medical Journal of Chinese PLA,2017,42(4):342-346.
[4] 龙 耀,刘艳秋,马鹏鹏,等.江西省中北部地区孕中期唐氏综合征筛查血清标志物中位数的构建[J].中南大学学报(医学版),2017,42(7):831-835.
Long Y,Liu YQ,Ma PP,et al.Establishment of medians for maternalserum markers in Down's syndrome screening during the second trimester of pregnancy in north-central region of Jiangxi province[J].Journal of Central SouthUniversity(Medical Scienc),2017,42(7):831-835.
[5] 苏 立,倪 敏,赵德华,等.河南地区孕中期唐氏综合征筛查人群中位数研究[J].中国妇幼保健,2016,31(8):1576-1578.
Su L,Ni M,Zhao DH,et al.Study on the median number of Down's syndrome screening population in Henan Province[J].Maternal and Child Health Care of China,2016,31(8):1576-1578.
[6] Alvarez-Nava F,Soto M,Lanes R,et al.Elevated second-trimester maternal serum β-human chorionic gonadotropin and amniotic fluid alpha-fetoproteinas indicators of adverse obstetric outcomes in fetal Turner syndrome[J].TheJournal of Obstetrics and Gynaecology Research,2015,41(12):1891-1898.
[7] Gu W,Lin J,Hou Y.The value of maternal first and second trimester serum data of β-hCG,PAPP-A,AFP and uE3 in the prediction of preeclampsia[J].Chinese Journal of Obstetrics and Gynecology,2015,50(2):101-107.
[8] Celik HG,Celik E,Yildirim G,et al.Do triple test results predict riskfor neonatal hyperbilirubinemia?[J].Pak J Med Sci,2017,33(4):979-983.
[9] 李华锋,张艳丽,杨海林,等.临沂地区孕中期产前筛查血清标志物中位数方程的建立及其与体重相关性研究[J].山东医学高等专科学校学报,2014,36(6):401-408.
Li HF,Zhang YL,Yang HL,et al.To establish the median equation ofprenatal screening serum marker of the second trime ster and study of its correlation with weight in Linyi region[J].Journal of Shandong Medical College,2014,36(6):401-408.
[10] Tu S,Rosenthal M,Wang D,et al.Performance of prenatal screening using maternal serum and ultrasound markers for Down syndrome in Chinese women: a systematic review and meta-analysis[J].BJOG,2016,123(Suppl 3):12-22.
[11] Yang F,Wang H,Shi JC,et al.Validity of different methods to prenatalscreening for Down's syndrom during first and second trimester pregnancy of Chinese-women[J].Biomed Environ Sci,2013,26(2):87-93.
[12] 何法霖,王 薇,钟 堃,等.2015年全国中孕期母血清产前筛查相关指标的调查与分析[J].现代检验医学杂志,2017,32(1):154-156,164.
He FL,Wang W,Zhong K,et al.Survey and analysis for maternal serum marker of prenatal screening in second trimester in 2015[J].Journal of Modern Laboratory Medicine,2017,32(1):154-156,164.
[13] 蒋宇林,刘俊涛,边旭明.唐氏综合征产前筛查的质量控制专题讨论:唐氏综合征产前筛查指标中位数倍数值中位数的监测和质量评价方法[J].实用妇产科杂志,2014,30(2):84-86.
Jiang YL,Liu JT,Bian XM.The panel discussion of the quality control ofdown syndrome prenatal screening:Monitoring and quality evalution method of median value of prenatal screening index for Down's syndrome[J].Journal of Practical Journal of Obstetrics and Gynecology,2014,30(2):84-86.

备注/Memo

备注/Memo:
基金项目:2017年度中山市社会公益科技研究项目(2017B1024)。
作者简介:梁培松(1976-),男,本科,副主任技师,主要从事临床检验免疫学工作和研究,E-mail:mark113388@163.com。
通讯作者:王伟佳,男,主任技师,博士后,硕士研究生导师,E-mail:xuelangchichao@163.com。
更新日期/Last Update: 2018-09-30