[1]王刚强,杨丽华,程 翔,等.高胆红素血症患者尿液微量蛋白、胱抑素C及尿常规检测对早期肾功能损伤的诊断价值[J].现代检验医学杂志,2018,33(05):70-73.[doi:10.3969/j.issn.1671-7414.2018.05.019]
　WANG Gang-qiang,YANG Li-hua,CHENG Xiang,et al.Diagnostic Value of Urine Microprotein,Cystatin C and Urine Routine Detection in Patients with Hyperbilirubinemia for Early Renal Injury[J].Journal of Modern Laboratory Medicine,2018,33(05):70-73.[doi:10.3969/j.issn.1671-7414.2018.05.019]
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高胆红素血症患者尿液微量蛋白、胱抑素C及尿常规检测对早期肾功能损伤的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
70-73
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Diagnostic Value of Urine Microprotein,Cystatin C and Urine Routine Detection in Patients with Hyperbilirubinemia for Early Renal Injury
文章编号:
1671-7414(2018)05-070-04
作者:
王刚强1; 杨丽华1; 程 翔1; 江 岩1; 秦 爽1; 郑善銮1; 郝晓柯1; 陈 茜2; 李 岩3
1.空军军医大学第一附属医院全军临床检验医学中心,西安 710032; 2.延安大学,陕西延安 716000; 3.空军军医大学唐都医院检验科,西安 710038
Author(s):
WANG Gang-qiang1; YANG Li-hua1; CHENG Xiang1; JIANG Yan1;  QIN Shuang1; ZHENG Shan-luan1; HAO Xiao-ke1; CHEN Qian2; LI Yan3
1.PLA Center for Clinical Laboratory Medicine,the First Affiliated Hospital of Air Force Medical University, Xi'an 710032,China; 2.Yan'an University,Shaanxi Yan'an 716000,China; 3.Department of Clinical Laboratory,Tangdu Hospital Affiliated to Air Force Medical University,Xi'an 710038,China
关键词:
高胆红素血症;  尿α1-微球蛋白;  尿β2-微球蛋白;  胱抑素;  尿液常规
分类号:
R575; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.05.019
文献标志码:
A
摘要:
目的 探讨高胆红素血症患者尿液微量蛋白、胱抑素C及尿常规检测在早期肾功能损伤中的诊断价值。方法 选取西京医院临床科室2016年3～12月间中、重度高胆红素血症(TBIL>171 μmol/L)患者160例为高胆红素血症组,同时选取同期正常查体人员100例为正常对照组,比较两组尿液微量蛋白[尿α1-微球蛋白(尿α1-MG),尿β2-微球蛋白(尿β2-MG)],尿液常规[尿胆红素(尿BIL),尿沉渣镜检肾小管上皮细胞],肾功能[血清胱抑素C(Cys C),肌酐(Cr),尿素氮(BUN)]水平和阳性率。结果 高胆红素血症组尿α1-MG,尿β2-MG,尿BIL和血清Cys C与正常对照组水平比较,差异均有统计学意义(t=-8.328,-2.669,-31.86,-8.246,均P<0.01),BUN和Cr差异无统计学意义(t=-0.629,2.769,均P>0.5); 高胆红素血症组尿α1-MG,尿β2-MG,尿BIL,血清Cys C和尿沉渣镜检肾小管上皮细胞与正常对照组阳性率比较,差异均有统计学意义(χ2=260.000,45.549,251.654,68.734, 247.694,均P<0.01)。结论 尿α1-MG,尿β2-MG,血清Cys C,尿BIL和尿沉渣镜检肾小管上皮细胞检测可提示中、重度高胆红素血症引发的早期肾功能损伤情况。
Abstract:
Objective To investigate the diagnostic value of urine microprotein,cystatin C and urine routine detection in patients with hyperbilirubinemia in early renal injury.Methods A totalof 160 patients with moderate to severe hyperbilirubinemia(TBIL>171 μmol/L)from March to December 2016 in clinical department of the Xijing Hospital were enrolled in the high bilirubin group,and at the same time,100 normal physical examination personnel were selected as the normal control group.Comparison of urine microalbuminuria [α1-microglobulin(urine α1-MG),urine β2-microglobulin(urine β2-MG)],urine routine urinary [bilirubin(urine BIL),urine sediment Microscopic examination of renal tubular epithelial cells],renal function[serum cystatin C(Cys C),creatinine(Cr),urea nitrogen(BUN)] level and positive rate.Results The levels of urinary α1-MG,urinary β2-MG,urinary BIL,and serum Cys C in the hyperbilirubinemia group were significantly different from those in the normal control group(t=-8.328,-2.669,-31.86,-8.246,both P<0.01),but difference of BUN,Cr was not statistically significant(t=-0.629,2.769,both P>0.5),urinary α1-MG,urine β2-MG,urine BIL,serurn Cys C and the positive rate of renal tubularepithelial cells in urine sediments of hyperbilirubinemia group were compared with the normal control group was statistically significant(χ2=260.000,45.549,251.654,68.734,247.694,both P<0.01).ConclusionUrine α1-MG,urine β2-MG,serum Cys C,urinary BIL,urine sediment microscopic examination of renal tubular epithelial cells may indicate early renal damage caused by moderate and severe hyperbilirubinemia.

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备注/Memo

备注/Memo:
作者简介:王刚强(1987-),男,本科,主管检验技师,主要从事临床血液及体液学检验,E-mail:wanggangqiang0802@126.com。
通讯作者:程 翔(1986-),女,本科,主管检验技师,主要从事临床血液及体液学检验,E-mail:mk921@163.com。
更新日期/Last Update: 2018-09-30