[1]高玉芳,王 敏,刘振社,等.血浆hs-CRP和血清HCY水平检测对缺血性眼病的诊断价值[J].现代检验医学杂志,2018,33(05):105-107.[doi:10.3969/j.issn.1671-7414.2018.05.028]
　GAO Yu-fang,WANG Min,LIU Zhen-she,et al.Clinical Value of High Sensitivity C-reactive Protein and Homocysteine in Patients with Ischemic Ophthalmopathy[J].Journal of Modern Laboratory Medicine,2018,33(05):105-107.[doi:10.3969/j.issn.1671-7414.2018.05.028]
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血浆hs-CRP和血清HCY水平检测对缺血性眼病的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
105-107
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Clinical Value of High Sensitivity C-reactive Protein and Homocysteine in Patients with Ischemic Ophthalmopathy
文章编号:
1671-7414(2018)05-105-03
作者:
高玉芳1; 王 敏2; 刘振社1; 张芝亚1; 闻啟富1
1.咸阳市中心医院检验科,陕西咸阳 712000; 2.咸阳市第一人民医院,陕西咸阳 712000
Author(s):
GAO Yu-fang1; WANG Min2; LIU Zhen-she1; ZHANGZhi-ya1; WEN Qi-fu1
1.Department of Clinical Laboratory,Central Hospital of Xianyang,Shaanxi Xianyang 712000,China; 2.the First People's Hospital of Xianyang,Shaanxi Xianyang 712000,China
关键词:
缺血性眼病;  同型半胱氨酸;  超敏C反应蛋白
分类号:
R771; R466.112
DOI:
10.3969/j.issn.1671-7414.2018.05.028
文献标志码:
A
摘要:
目的 探讨血浆超敏C-反应蛋白(hs-CRP)和血清同型半胱氨酸(HCY)水平在缺血性眼病(IOP)中的临床诊断价值。方法 已确诊为IOP的175例患者作为试验组,以年龄、性别与试验组患者一比一配对,选取175例健康体检者作为对照组。采用全自动特定蛋白分析系统及配套试剂,以散射免疫比浊法对血浆hs-CRP水平进行测定; 采用全自动生化分析仪及HCY检测试剂盒,以速率法对血清HCY水平进行测定。高水平半胱氨酸血症定义为总HCY浓度>15.0 μmol/L; 高水平hs-CRP定义为血浆hs-CRP浓度>0.5 mmol/L。对血浆hs-CRP和血清HCY检测数据进行回顾性分析。结果 IOP组患者中血浆hs-CRP(3.65±3.60 mmol/L)和血清HCY水平(49.45±31.04 μmol/L)明显高于健康对照组(0.66±0.30 mmol/L和12.69±5.23 μmol/L),差异均有统计学意义(t=2.623,3.557,均P<0.05); IOP组患者中高同型半胱氨酸血症的发病率为82.9%,高水平hs-CRP的发病率为72.6%,明显高于健康对照组,差异均有统计学意义(χ2=117.978,56.149,均P=0.000)。结论 血浆hs-CRP和血清HCY可作为诊断IOP的标志分子,有助于IOP患者的诊断。
Abstract:
Objective To investigate the clinical value ofplasma high sensitivity C-reactive protein(hs-CRP)and serum homocysteine(HCY)levels in patients with ischemic ophthalmopathy(IOP).Methods 175 cases of IOP patients were selected as experimental group.Accordingto sex and age,175 cases of health examination subjects were collected as control group by a way of same-size ratio.The plasma hs-CRP level was determined by scatter immunoturbidimetry with automatic specific protein analysis system andmatching reagent,and serum HCY level was measured by rate method with automatic biochemical analyzer and HCY detection kit.Total HCY concentration>15.0 μmol/L was defined as high level homocysteinemia,and plasma hs-CRP concentration>0.5 mmol/L plasma concentration >0.5 mmol/L was defined as high level hs-CRP.Hs-CRP and HCY levels were analyzed retrospectively.Results The levels of hs-CRP(3.65±3.60 mmol/L)and HCY(49.45±31.04 μmol/L)were significantly higher than those in control groups(0.66±0.30 mmol/Land 12.69±5.23 μmol/L),and the difference had statistical significance(t=2.623,3.557,all P<0.05).The incidence of Hyperhomocysteinemia was 82.9%,and that of high-level hs-CRP was 72.6%,the difference had statistical significance(χ2=117.978,56.149,all P=0.000).Conclusion The levels of hs-CRP and HCY played an important role in the diagnosis of IOP.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生科研基金资助项目(编号:2014E12)。
作者简介:高玉芳(1982-),女,硕士,副主任医师,研究方向:临床检验诊断,E-mail:gaoyf06@126.com。
通讯作者:王 敏(1979-),男,硕士,主治医师,研究方向:眼底病,E-mail:angin200l@126.com。
更新日期/Last Update: 2018-09-30