[1]唐红秀,王 璐,万 楠,等.慢性心力衰竭患者外周血RDW与HDL-C水平的相关性分析[J].现代检验医学杂志,2018,33(06):88-90+94.[doi:10.3969/j.issn.1671-7414.2018.06.023]
　TANG Hong-xiu,WANG Lu,WAN Nan,et al.Relationship between High-density Lipoprotein Cholesterol and the Red Cell Distribution Width in Patients with Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2018,33(06):88-90+94.[doi:10.3969/j.issn.1671-7414.2018.06.023]
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慢性心力衰竭患者外周血RDW与HDL-C水平的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
88-90+94
栏目:
论著
出版日期:
2018-12-24

文章信息/Info

Title:
Relationship between High-density Lipoprotein Cholesterol and the Red Cell Distribution Width in Patients with Chronic Heart Failure
文章编号:
1671-7414(2018)06-088-04
作者:
唐红秀1; 王 璐2; 万 楠2; 胡晓芳2
1.锦州医科大学沈阳军区总医院研究生培养基地,辽宁锦州 121000; 2.沈阳军区总医院检验科,沈阳 110016
Author(s):
TANG Hong-xiu1; WANG Lu2; WAN Nan2; HU Xiao-fang2
1.Post Graduate Training Base of Shenyang Military Region General Hospital of Jizhou Medical University,Liaoning Jinzhou 121000 China; 2.Department of Clinical Laboratory,the General Hospital of Shenyang Military,Shenyang 110016,China
关键词:
慢性心衰;  红细胞分布宽度;  高密度脂蛋白胆固醇
分类号:
R541.6; R446.11
DOI:
10.3969/j.issn.1671-7414.2018.06.023
文献标志码:
A
摘要:
目的 研究慢性心力衰竭患者外周血红细胞分布宽度(RDW)与高密度脂蛋白胆固醇(HDL-C)水平之间的关系。方法 以沈阳军区总医院2016年8月～2018年8月门诊收治的162例慢性心力衰竭(chronic heart failure,CHF)患者为研究对象,用四分位数法将CHF患者分为四组,检测其RDW,HDL-C,hs-CRP和NT-proBNP等值,观察RDW与HDL-C之间的关系,采用单因素方差分析、秩和检验(Kruskal Wallis)与Pearson相关对数据进行统计学分析。结果 四组患者分别为39例、41例、38例和44例; 四组HGB(g/L)的水平分别为129.16±27.54,133.07±21.51,130.89±16.08和121.86±26.04; 四组Cr(μmol/L)的水平分别为74.2(55.62～88.08),80.14(63.00～95.25),77.30(64.03～91.57)和84.36(66.5～106.91); 四组LDL-C(mmol/L)的水平分别为2.45±0.69,2.40±0.85,2.43±0.87和2.12±0.53,将HGB,Cr和LDL-C值在四组间进行比较,差异均无统计学意义(F=1.854,P=0.140; H=4.740,P=0.192; F=1.865,P=0.138)。四组hs-CRP(mg/L)的水平分别为1.60(0.80～2.60),2.80(2.00～6.30),5.8(3.00～13.30)和8.80(4.20～19.45); 四组HDL-C(mmol/L)的水平分别为1.11±0.28,1.05±0.21,1.01±0.33和0.87±0.23,将hs-CRP和HDL-C值在四组间进行比较,差异有统计学意义(H=44.106,P<0.001; F=6.546,P<0.001)。CHF患者的RDW与HDL-C水平呈负相关(r=-0.509,P<0.001),与hs-CRP呈正相关(r=0.341,P<0.001),与NT-proBNP相关性较低,且无统计学意义(r=0.107,P=0.174)。心功能分级越高,RDW的值也越高,心功能Ⅳ级患者的RDW值与心功能Ⅱ,Ⅲ级患者比较,差异均具有统计学意义(F=9.391,P=0.003; F=8.648,P=0.004)。结论 CHF患者RDW与血清HDL-C存在负相关,并且RDW值随着心衰的严重程度增加而增加。
Abstract:
Objective To explore the relationship betweenred blood cell distribution width and high-density lipoprotein cholesterol inpatients with chronic heart failure(CHF).Methods 162 patients with CHF in the General Hospital of Shenyang Military from August 2016 toAugust 2018 were enrolled with a retrospective analysis,the levels of RDW,HDL-C,hs-CRP and NT-proBNP were detected and Statistical analysis with One-wayANOVA,rank sum test(Kruskal Wallis)and Pearson on the data.Results The four groups of patients were 39,41,38 and 44.The levels ofthe four groups of HGB(g/L)were 129.16±27.54,133.07±21.51,130.89±16.08 and 121.86±26.04,the levels of the four groups of Cr(μmol/L)were 74.2(55.62～88.08),80.14(63.00～95.25),77.30(64.03～91.57)and 84.36(66.5～106.91).The levels of the four groups of LDL-C(mmol/L)were 2.45±0.69,2.40±0.85,2.43±0.87 and 2.12±0.53.HGB,Cr and LDL-C valueswere compared between the four groups,and the difference was not statisticallysignificant(F=1.854,P=0.140; H=4.740,P=0.192; F=1.865,P=0.138).The levels of the four groups of hs-CRP(mg/L)were 1.60(0.80～2.60),2.80(2.00～6.30),5.8(3.00～13.30)and 8.80(4.20～19.45).The levels of thefour groups of HDL-C(mmol/L)were 1.11±0.28,1.05±0.21,1.01±0.33 and 0.87±0.23,hs-CRP and HDL-C values were compared between the four groups,and the difference was statistically significant(F=44.106,P<0.001; H=6.546,P<0.001).RDW was negatively correlated with HDL-C level in CHF patients(r=-0.509,P<0.001),positively correlated with hs-CRP(r=0.341,P<0.001),low correlation with NT-proBNP and had no significantly statistical differences.The change of RDW value increases with the increasing of cardiac function classification,there were significantly statistical differences between Cardiac function grade Ⅳ and cardiac function grade II,III in CHF patients(F=9.391,P=0.003; F=8.648,P=0.004).Conclusion There was a negative correlation between RDW and serum HDL-C in patients with chronic heart failure and increases with the severity of heart failure.

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备注/Memo

备注/Memo:
作者简介:唐红秀(1992-),女,硕士研究生,E-mail:756213220@qq.com。
通讯作者:胡晓芳,E-mail:hxf630212@msn.com.cn。
更新日期/Last Update: 2018-11-30