[1]曾纪扬,吴碧云,陆美环.红细胞相关参数与HbA2联合检测在α-珠蛋白生成障碍性贫血并发缺铁性贫血诊断中的应用[J].现代检验医学杂志,2018,33(06):103-106.[doi:10.3969/j.issn.1671-7414.2018.06.027]
　ZENG Ji-yang,WU Bi-yun,LU Mei-huan.Application of Combined Detection of Red Blood Cell Related Parameters and HbA2 in the Diagnosis of Alpha-Globin-Producing Anemia Complicated with Iron Deficiency Anemia[J].Journal of Modern Laboratory Medicine,2018,33(06):103-106.[doi:10.3969/j.issn.1671-7414.2018.06.027]
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红细胞相关参数与HbA2联合检测在α-珠蛋白生成障碍性贫血并发缺铁性贫血诊断中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
103-106
栏目:
论著
出版日期:
2018-12-24

文章信息/Info

Title:
Application of Combined Detection of Red Blood Cell Related Parameters and HbA2 in the Diagnosis of Alpha-Globin-Producing Anemia Complicated with Iron Deficiency Anemia
文章编号:
1671-7414(2018)06-103-04
作者:
曾纪扬; 吴碧云; 陆美环
英德市妇幼保健计划生育服务中心,广东英德 513000
Author(s):
ZENG Ji-yang; WU Bi-yun; LU Mei-huan
Department of Clinical Laboratory,Maternity and Child Health Care Hospital of Yingde,Guangdong Yingde 513000,China
关键词:
血红蛋白A2;  红细胞相关参数;  α-珠蛋白生成障碍性贫血;  缺铁性贫血
分类号:
R556.61; R446.11
DOI:
10.3969/j.issn.1671-7414.2018.06.027
文献标志码:
A
摘要:
目的 探讨红细胞相关参数与血红蛋白A2(HbA2)联合检测在α-珠蛋白生成障碍性贫血并发缺铁性贫血诊断中的应用。方法 回顾性分析选取2017年1月～2018年6月α-珠蛋白生成障碍性贫血和缺铁性贫血患者,其中α-珠蛋白生成障碍性贫血组1 164例、缺铁性贫血组974例、α-珠蛋白生成障碍性贫血并发缺铁性贫血组765例,所有患者均经过地贫基因诊断和铁蛋白测定。另选同期健康体检者500例作为对照组。所有研究对象进行红细胞相关参数(包括Hb,MCV,MCH,MCHC,RDW)和HbA2检测并比较检测结果。结果 α-珠蛋白生成障碍性贫血组的HbA2,Hb,MCV,MCH,MCHC高于缺铁性贫血组,α-珠蛋白生成障碍性贫血并发缺铁性贫血组的HbA2水平低于缺铁性贫血组,MCV平均值高于缺铁性贫血组,差异均有统计学意义(P<0.05); 不同基因型珠蛋白生成障碍性贫血中HbA2,Hb,MCV,MCH,MCHC水平比较,在-α3,7(4,2)/ αα,-sea/αα,-α3,7(4,2)/--sea中依次降低。与对照组比较,其余各组红细胞指标与HbA2水平统计方差值F=53.3～1103.7,均P<0.01; 与ααcs/αα比较,其余各基因型组红细胞指标与HbA2水平统计方差值F=71.8～903.2,均P<0.01。结论利用红细胞相关参数各项指标与HbA2相结合检测,能够有效地鉴别出缺铁性贫血和α-珠蛋白生成障碍性贫血以及α-珠蛋白生成障碍性贫血并缺铁性贫血。
Abstract:
Objective To discuss the application of combined detection of red blood cell(RBC)related parameters and HbA2 in the diagnosisof alpha-globin-producing anemia complicated with iron deficiency anemia(IDA).Methods A retrospective analysis was conducted for patients with alpha-globin-producing anemia and iron deficiency anemia from January 2017 to June 2018 which were divided into 1 164 cases of alpha-globin-producing anemia group,974 cases of iron deficiency anemia group and 765 cases of alpha-globin-producing anemia complicated with IDA group.Another 500 healthy persons in the same period were selected as control group.All patients were diagnosed by genetic diagnosis of thalassemia and ferritin.Another 500 healthy persons in the same period were selected as control group.All subjects were tested for RBC related parameters(including Hb,MCV,MCH,MCHC and RDW)and HbA2 and theresults were compared.Results The HbA2,Hb,MCV,MCH and MCHC in the alpha-globin-producing anemia group were higher than that of theiron deficiency anemia group.The HbA2 level of the alpha-globin-producing anemia combined with the IDA group was lower than that of the iron deficiency anemia group and the MCV average was higher than that of the iron deficiency anemiagroup.The differences were statistically significant(P<0.05).The levelsof HbA2,Hb,MCV,MCH and MCHC in different genotypes of thalassemia decreasedfrom -α3,7(4,2)/αα,-sea/αα to -α3,7(4,2)/--sea.Compared with control group,statistical variance of erythrocyte indexand HbA2 level were(F=53.3～1 103.7,P<0.01).Compared with ααcs/αα,statistical variance of erythrocyte index and HbA2 level were F=71.8～903.2,P<0.01.Conclusion The combination of allRBC related parameters indicators and HbA2 can effectively identify iron deficiency anemia,alpha-globin-producing anemia and alpha-globin-producing anemia with IDA.

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备注/Memo

备注/Memo:
作者简介:曾纪扬(1980-),男,大学本科,主管检验师,主要从事临床生化与检验研究,E-mail:zjy801027@126.com。
更新日期/Last Update: 2018-11-30