[1]毛彤瑶,郭佳培,李 宁,等.肾性贫血患者外周血红细胞参数与微炎症指标相关性分析[J].现代检验医学杂志,2018,33(06):146-148+152.[doi:10.3969/j.issn.1671-7414.2018.06.038]
　MAO Tong-yao,GUO Jia-pei,LI Ning,et al.Detection of Erythrocyte Parameters in Patients with Renal Anemia and Its Correlation with the Index of Microinflammation[J].Journal of Modern Laboratory Medicine,2018,33(06):146-148+152.[doi:10.3969/j.issn.1671-7414.2018.06.038]
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肾性贫血患者外周血红细胞参数与微炎症指标相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
146-148+152
栏目:
检验与临床
出版日期:
2018-12-24

文章信息/Info

Title:
Detection of Erythrocyte Parameters in Patients with Renal Anemia and Its Correlation with the Index of Microinflammation
文章编号:
1671-7414(2018)06-146-04
作者:
毛彤瑶; 郭佳培; 李 宁; 韩 雪; 石 峻; 赵俊暕
华北理工大学附属医院检验科,河北唐山 063000
Author(s):
MAO Tong-yao; GUO Jia-pei; LI Ning; HAN Xue; SHI Jun; ZHAO Jun-jian
Department of Clinical Laboratory, Affiliated Hospital of NorthChina University of Science and Technology,Hebei Tangshan 063000,China
关键词:
肾性贫血;  红细胞参数;  微炎症状态;  红细胞体积分布宽度;  清蛋白/球蛋白比值
分类号:
R556; R446.11
DOI:
10.3969/j.issn.1671-7414.2018.06.038
文献标志码:
A
摘要:
目的 通过分析肾性贫血患者红细胞参数与微炎症指标的相关性,对肾性贫血患者微炎症做出有效提示,利于微炎症状态尽早纠正。方法选取2017年3月～2018年3月在肾内科住院的慢性肾衰竭(CRF)伴贫血患者120例作为病例组,选同期体检正常人群150例作为对照组。对病例组与对照组血细胞参数RBC,HGB,MCV,MCH,MCHC和RDW进行检测; 对肾性贫血患者红细胞形态学进行检查; 对微炎症相关指标CRP,ALB和A/G进行检测; 对红细胞参数和微炎症指标进行相关性分析。结果 病例组RDW和CRP明显高于对照组,RBC,ALB和A/G值明显低于对照组,差异均有统计学意义(P<0.05),病例组MCV,MCH和MCHC与对照组比较差异无统计学意义(P>0.05); 细胞形态学提示,肾性贫血患者成熟红细胞普遍存着红细胞大小不等、异形性的特点; 病例组RDW与CRP,ALB和A/G值存在相关性。结论 肾性贫血以正细胞正色素性贫血为主,并伴有一定比例其他类型的贫血,RDW与微炎症状态有关,RDW可对肾性贫血患者处于微炎症状态起到提示作用。
Abstract:
Objective To analyze the correlation between changes of erythrocyte parameters of renal anemia patients and micro inflammatorystate in order to make hints for early diagnosis of renal anemia and estimate micro inflammatory state.Methods Selected 120 samples of CRF patients in nephrology department from March 2016 to March 2017 as case groupand selected 150 normal persons at the same time as matched group,and tested the blood routine parameters(RBC,HGB,MCV,MCH,MCHC and RDW)of two groups,red blood cell morphology,micro inflammatory state indexes(CRP,ALB,A/G)and did statistical analysis of erythrocyte parameters and micro inflammatory state indexes.Results By microscopic examination of patients with RBC,it was common that the size of red cells was non-uniform distribution.The indexes(MCV,MCH and MCHC)of case group were normal,while there was apparent difference of RBC,RDW,CRP,ALB and A/G index between case group and matchedgroup.The case group's RDW and CRP indexes were higher than matched group obviously,and RBC,ALB and A/G were lower than matched group.There was correlation between RDW and CRP,ALB and A/G in case group.Conclusion RDW can be regarded as evaluating indicator of micro inflammatory state,italso offers prompt effect for micro inflammatory state process of renal anemia patients.

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备注/Memo

备注/Memo:
基金项目:河北省医学适用技术跟踪项目(G2018066); 河北省医学科学研究重点课题(20180771)。
作者简介:毛彤瑶(1989-),女,研究生,检验技师,研究方向:临床血液学检验,E-mail:mytsmyts@126.com。
通讯作者:赵俊暕,硕士研究生,副主任技师,研究方向:临床血液学检验,E-mail:19931503852,meiyitangshan@163.com。
更新日期/Last Update: 2018-11-30