[1]程蓓蕾,王福祥,杨丹蓉.血清hs-CRP,β-HCG和孕酮的联合检测在预测先兆流产中的临床应用[J].现代检验医学杂志,2019,34(01):51-54.[doi:10.3969/j.issn.1671-7414.2019.01.013]
　CHENG Bei-lei,WANG Fu-xiang,YANG Dan-rong.Clinical Application of Combined Detection of hs-CRP，β-HCG，and Progesterone in Predicting Threatened Abortion[J].Journal of Modern Laboratory Medicine,2019,34(01):51-54.[doi:10.3969/j.issn.1671-7414.2019.01.013]
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血清hs-CRP,β-HCG和孕酮的联合检测在预测先兆流产中的临床应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
51-54
栏目:
论著
出版日期:
2019-02-28

文章信息/Info

Title:
Clinical Application of Combined Detection of hs-CRP，β-HCG， and Progesterone in Predicting Threatened Abortion
文章编号:
1671-7414(2019)01-051-04
作者:
程蓓蕾; 王福祥; 杨丹蓉
(海盐县妇幼保健院检验科， 浙江嘉兴314300)
Author(s):
CHENG Bei-lei; WANG Fu-xiang; YANG Dan-rong
(Department of Clinical Laboratory， Haiyan Maternal and Child Health Hospital，Zhejiang Jiaxing 314300，China)
关键词:
先兆流产; 超敏C-反应蛋白; β-人绒毛膜促性腺激素; 孕酮
分类号:
R714.21；R392.11
DOI:
10.3969/j.issn.1671-7414.2019.01.013
文献标志码:
A
摘要:
目的探讨血清超敏C-反应蛋白(hypersensitive C-reac tive protein，hs-CRP)，β-人绒毛膜促性腺激素(β-human chorionic gonadotropin ，β-HCG)和孕酮(Progesterone，P)的联合检测在预测早期先兆流产中的临床应用。 方法选择2017年1～12月孕龄为8～12周并发生先兆流产的61例孕妇为研 究对象，选择同期孕龄相同的72例正常妊娠孕妇为对照组。采用化学发光法检测血清β-HC G和P的水平，并使用增强型免疫比浊法检测血清hs-CRP水平。通过Logistic回归分析先兆 流产的独立危险因素，并以ROC曲线检测三项指标对预测先兆流产的效能。结果 正常妊娠组血清P，β-HCG水平分别为27.76±3.38 ng/ml和8 886±1 303 mIU/ml，均明显高于先兆流产组(19.62±2.58 ng/ml，6 338±1 461 mIU/ml)，差异具有 统计学意义( t=15.42，10.63，均P <0.000 1)；而正常妊娠组血清hs-CRP水平(5.9 5±2.19 mg/L)明显低于先兆流产组(14.91±6.55 mg/L)，差异具有统计学意义( t=10 . 92，P <0.000 1)。单变量或多变量Logistic回归分析发现，血清hs-CRP，P和β-HCG均 是先兆流产的独立影响因素( OR=2.060，0.408，0.999，均P <0.000　1)或( OR=1 .803，0.389，0.998，均P <0.05)。血清hs-CRP，β-HCG和P诊断先兆流产的受试者工作曲线(receiver operating characteristic curve，ROC)曲线下面积分别为0.954，0 .972和0.911(均 P <0.000　1)；三项目联合检测的ROC曲线下面积为0.997( P <0.000　1)。结论联合检测血清hs-CRP，β-HCG和P的水平，在早期诊断先兆流产的发生中具有重要临床应用价值。
Abstract:
Objective To study the combined detection value of serum hypersensitive C-reactive protein (hs-CRP)，β-human chorionic gona dotropin (β-HCG)，and progesterone (P) in the prediction of threatened abortio n．Methods A total of 61 pregnant women with threatened a bortion from January to December 2017 were selected as research subjects in this study，and 72 normal pregnant women were selected as control group．All pregnan t women had a gestational age of 8～12 weeks．The serum P and β-HCG of all gro ups were detected by chemiluminescence immunoassay，and serum hs-CRP was analyz ed by enhanced immuno-turbidimetric method．Logistic regression analyzed the in dependent risk factors for threatened abortion，and ROC curve was used to predic t the efficacy of three markers in threatened abortion．Results The serum β-HCG and progesterone of normal control were 27.76±3.38 n g/ml and 8 886±1 303 mIU/ml，which was higher than those of threatened abortion (19 .62±2.58 ng/ml，6 338±1 461 mIU/ml)，and there was significant difference ( t =15.42，10.63，all P <0.000　1)．The serum hs-CRP level in normal grou p　(5.9 5±2.19 mg/L) was　significantly lower than the group with threatened abortion (14.91±6.55　mg/L) and there was significant difference　( t=10.92，P <0. 000　1)．Univariate or multivariate logistic regression analysis found that seru m hs-CRP，P and β-HCG were independent influencing factors of threatened abor tion ( OR =2.060，0.408 and 0.999，all P <0.000　1) or ( OR =1.803， 0.389 and 0.998，all P <0.05)．The area under the receiver operating chara cteristic curve (ROC) of serum hs-CRP，β-HCG and P were 0.954，0.972 and 0.911，respective ly (all P <0.000　1)．And the AUC of the combination of three markers was 0 .997 ( P <0.000　1)．Conclusion The combined detectio n of serum hs-CRP，β-HCG and P in the prediction of early threatened abortion has a great clinical value．

参考文献/References:


[1］朱春燕，吴娟，麦炜碧，等．广州地区孕妇先兆流产发病状况及影响因素 ［J］．中国妇幼保健，2013，28(1)：104-106． ZHU Chunyan，WU Juan，MAI Weibi，et al．Prevalence incidence and inf luencing factors of threatened abortion among pregnant women in Guangzhou city［ J］．Maternal and Child Health Care of China，2013，28(1)：104-106．
[2］FATEMA N，DEEBA F，AKTER S，et al．CRP(C-reactive protein) in early preg nancy predictor for development of GDM［J］．Mymensingh Med J，2016，25(2)：271 -276．
[3］谢幸，孔北华，段涛，等．妊娠诊断［M］．妇产科学．9版．北京：人民卫生 出版社，2018：43-44． XIE Xing，KONG Beihua，DUAN Tao，et al．Diagnosis of pregnancy［M］．Obstetrics and Gynecology，9th Ed．Beijing：People’s Medical Publishing Hou se，2018：43-44．
[4］杨亚滨，张艳梅，索磊．血清孕酮、HCG联合检测在早期先兆流产中的临床意义［J ］．中国优生与遗传杂志，2013，21(1)：52，76． YANG Yabin，ZHANG Yanmei，SUO Lei．Serum pro-gesterone，HCG united detection in early threatening miscarriage of clinical significance［J］．Chinese Journal of Birth Health & Heredity，2013，21(1)：52，76．
[5］沈红云，张文兵．血清孕酮和β-HCG联合检测在早期先兆流产中的临床价值［J］ ．中华全科医学，2013，11(9)：1389-1390． SHEN Hongyun，ZHANG Wenbing．The value of combined progesterone and β-HCG in diagnosis of early threatened abortion［J］．Chinese Journal of Gener al Practice，2013，11(9)：1389-1390．
[6］杨学妞，张觇宇．动态血清孕酮及β-HCG值对早期异常妊娠的临床意义［J］．中 国计划生育和妇产科，2010，2(6)：20-23． YANG Xueniu，ZHANG Chanyu．Clinical significance of dynamic determin ation of serum progesterone and β-HCG on diagnosis and treatment of early abno rmal pregnancy disease［J］．Chinese Journal of Family Planning & Gynecotokology ，2010，2(6)：20-23．
[7］DE OLIVEIRA L C，FRANCO-SENA A B，REBELO F，et al．Factors associated with maternal serum C-reactive protein throughout pregnancy：A longitudinal study i n women of Rio de Janeiro，Brazil［J］．Nutrition，2015，31(9)：1103-1108．
[8］BALDINI D，SAVOIA M V，SCIANCALEPORE A G，et al．High progesterone levels on the day of HCG administration do not affect the embryo quality and the reprodu ctive outcomes of frozen embryo transfers［J］．Clin Ter，2018，169(3)：e91-e95 ．
[9］杨洁．不同孕周非治疗性早产产妇的影响因素分析［J］．中国现代药物应用，2017 ，11(15)：71-73． YANG Jie．Analysis of influencing factors of non-therapeutic premat ure pregnant woman in different gestational weeks［J］．Chin J Mod Drug Appl，20 17，11(15)：71-73．
[10］ONUEGBU A J，OLISEKODIAKA J M，UDO J U，et al．Evaluation of hig h-sensitivity C-reactive protein and serum lipid profile in southeastern Niger ian women with pre-eclampsia［J］．Med Princ Pract，2015，24(3)：276-279．
[11］张国辉．血液HBP，CRP和WBC联合检测对儿童脓毒血症早期诊断价值研究［J］．现 代检验医学杂志，2018，33(4)：107-111． ZHANG Guohui．Value of combined detection of blood HBP，CRP and WBC in early diagnosis of children’s sepsis［J］．Journal of Modern Laboratory Medi cine，2018，33(4)：107-111．
[12］庞燕，陈秀甜，梁锦辉，等．血清C反应蛋白在早产预测中的作用［J］．国际检验 医学杂志，2017，38(19)：2741-2743． PANG Yan，CHEN Xiutian，LIANG Jinhui，et al．The role of serum C-re active protein in predicting preterm delivery［J］．International Journal of Lab oratory Medicine，2017，38(19)：2741-2743．
[13］华关民，唐荣德，梁剑宁，等．血清CRP与hs-CRP检测值比较与相关性分析［J］ ．中国医学创新，2014，11(3)：32-34． HUA Guanmin，TANG Rongde，LIANG Jianning，et al．Comparison and corr elation analysis of detected-values for CRP and hs-CRP in sera［J］．Medical I nnovation of China，2014，11(3)：32-34．

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备注/Memo

备注/Memo:

作者简介：程蓓蕾(1980-)，男，大学本科，主管检验师，主要从事妊娠并发症研究，E-mail：18957328912@163.com。
更新日期/Last Update: 2019-02-28