[1]朱建光,沈露,张潮,等.儿童哮喘患者血清IL-33和TSLP水平检测的临床意义及与IgE相关性分析[J].现代检验医学杂志,2019,34(01):58-61.[doi:10.3969/j.issn.1671-7414.2019.01.015]
 ZHU Jian-guang,SHEN Lu,ZHANG Chao,et al.Clinical Significance of Detection of Serum IL-33 and TSLP Levels in Children with Asthma and Correlation with IgE[J].Journal of Modern Laboratory Medicine,2019,34(01):58-61.[doi:10.3969/j.issn.1671-7414.2019.01.015]
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儿童哮喘患者血清IL-33和TSLP水平检测的临床意义及与IgE相关性分析()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
58-61
栏目:
论著
出版日期:
2019-02-28

文章信息/Info

Title:
Clinical Significance of Detection of Serum IL-33 and TSLP Levels in Children with Asthma and Correlation with IgE
文章编号:
1671-7 414(2019)01-058-04
作者:
朱建光a沈露b张潮c郑曦a
(咸宁市中心医院,湖北科技学院附属第一医院a.检验科;b.神经内科; c.儿科,湖北咸宁437100)
Author(s):
ZHU Jian-guangaSHEN LubZHANG ChaocZHENG Xi a
( a .Department of Clinical Laboratory; b .Department of P ediatric; c .Department of Neurology,Xianning Central Hospital,the First Affil iated Hospital of Hubei University of Science and Technology,Hubei Xianning 437100,Chin a)
关键词:
儿童哮喘白介素-33胸腺基质淋巴细胞生成素免疫球蛋 白
分类号:
R725.6;R392.11
DOI:
10.3969/j.issn.1671-7414.2019.01.015
文献标志码:
A
摘要:
目的探究白介素-33(IL-33)和胸腺基质淋巴细胞生成素 (TSLP)在儿童哮喘患者中可能产生的作用。方法收集咸宁市中心医 院2016年1月~2018年1月收治的急性发作期哮喘患儿120例和同期健康儿童120例,分别作为 实验组和对照组。采用ELISA法检测哮喘患儿治疗前与治疗后血清中IL-33,TSLP和IgE水平 ;用Pearson分析IL-33,TSLP与IgE的相关性。结果对急性发作期 儿 童哮喘患者血清中IL-33,TSLP和IgE表达水平进行分析,血清IL-33水平明显高于健康 对照组,经治疗后显著下降,差异有统计学意义( t=15.788,P <0.05);血清TSLP水 平高于对照组,经治疗后下降,差异有统计学意义( t=10.876,P <0.05),对IL-33 ,TSLP与IgE进行相关分析,IL-33与IgE呈正相关( r=0.694,P <0.001);TSLP与IgE 呈正相关( r=0.765,P <0.001)。结论在儿童哮喘患者中IL -33和TSLP可能对疾病的发生和发展起重要作用,是儿童哮喘潜在的诊断新指标及治疗新靶 点。
Abstract:
Objective To explore the roles of interleukin- 33 (IL-33) and thymic stromal lymphopoietin (TSLP) in the children with asthma .Methods Selected 120 cases of asthmatic children who ha d treated in the Xianning Central Hospital from January 2016 to January 2018,an d 120 healthy children served as normal controls.IL-33 and TSLP of serum in ch ildren with asthma were detected by ELISA,and correlations between the two and IgE was analyzed.Results The serum levels of IL-33,TSL P and IgE in children with acute asthma were analyzed.Serum IL-33 levels were significantly higher than those in controls and decreased after treatment.The d ifference was statistically significant ( t=15.788,P <0.05).Serum TSLP lev els were higher than controls and decreased after treatment.The difference was statistically significant ( t=10.876,P <0.05).Correlation analysis between IL-33,TSLP and IgE.IL-33 was positively correlated with IgE ( r=0.694,P <0.001),but TSLP was positively correlated with IgE ( r=0.765,P <0.001) .〖 WT5Conclusion IL-33 and TSLP may play an important role in th e occurrence and development of the disease in children with asthma,and it is a potential diagnostic indicator and a new therapeutic target for childhood asthm a.

参考文献/References:


[1]KEGLOWICH L F,BORGER P.The three A’s in asthma-airway smooth muscle,airway remodeling & angiogenesis[J].Open Respir Med J,2015,9:70-8 0.
[2]张春霞,任少敏,王继春,等.哮喘儿童诱导痰中TSLP,IL-33的表达及意义[J] .兵器装备工程学报,2016,37(11):176-178. ZHANG Chunxia,REN Shaomin,WANG Jichun,et al.The levels and sign ificance of TSLP,IL-33 in the induced sputum from children with asthmatic[J] .Journal of Ordnance Equipment Engineering,2016,37(11):176-178.
[3]张鑫,王炜,孙英.上皮源性细胞因子IL-33,IL-25和TSLP在哮喘发病机制中的 作用[J].微生物学免疫学进展,2017,45(5):53-58. ZHANG Xin,WANG Wei,SUN Ying.Roles of epithelial-derived cytokine s IL-33,IL-25 and TSLP in the pathogenesis of asthma[J].Progress in Microb iology and Immunology,2017,45(5):53-58.
[4]赵艳飞,杨慧湘,张湘玲.小儿哮喘非急性发作期IgE,EOS,LTE-4检测及其临床 意义[J].现代医药卫生,2017,33(22):3414-3415,3419. ZHAO Yanfei,YANG Huixiang,ZHANG Xiangling.Detection of IgE,EOS, LTE-4 of infantile asthma in non-acute stage and its clinical significance[J ].Journal Modern Medical and Health,2017,33(22):3414-3415,3419.
[5]谭春玲.小儿哮喘发病机理与治疗探讨[J].中国农村卫生,2016(18):96,88. TAN Chunling.Discussion on the pathogenesis and treatment of asthma in children[J].China Rural Health,2016(18):96,88.
[6]郭海琴,马文娴,吴昌归.重症哮喘发病机制的研究进展[J].临床肺科杂志,20 17,22(10):1903-1909. GUO Haiqin,MA Wenxian,WU Changgui.Progress in the pathogenesis of severe asthma[J].Journal of Clinical Pulmonary Medicine,2017,22(10):1903 -1909.
[7]王文辉,张倩华.小儿哮喘临床因素的分析[J].兵团医学,2015,45(3):24-2 5. WANG Wenhui,ZHANG Qianhua.Analysis of clinical factors in children with asthma[J].Journal of Bingtuan Medicine,2015,45(3):24-25.
[8]PAPAZIAN D,HANSEN S,WURTZEN P A.Airway response stowards allergens-fr om the airway epithelium to T cells[J].Clin Exp Allergy,2015,45(8):1268-1 287.
[9]孙莉,陈清阁,倪振华,等.哮喘生物标志物研究新进展[J].中国全科医学,20 17,20(2):228-231. SUN Li,CHEN Qingge,NI Zhenhua,et al.Research progress of biomar kers in asthma[J].Chinese General Practice,2017,20(2):228-231.
[10]唐汉庆,王有科,黄月艳,等.胸腺基质淋巴细胞生成素与儿童哮喘严重 程度的相关性[J].中国全科医学,2017,20(S3):138-140. TANG Hanqing,WANG Youke,HUANG Yueyan,et al.Correlation between t hymic stromal lymphopoietin and the severity of children’s asthma[J].Chinese General Practice,2017,20(S3):138-140.
[11]史兆雯,蔡朱莺,王昌惠.哮喘急性发作患者血清中IL-18,IL-33表达意义及其 与肺功能的关系[J].同济大学学报(医学版),2017,38(6):58-62. SHI Zhaowen,CAI Zhuying,WANG Changhui.Serum IL-18 and IL-33 lev ers in patients with acute asthma attack and its relationship with pulmonary fun ction[J].Journal of Tongji University(Medical Sciences),2017,38(6):58-62 .
[12]章哲,张文喜,赵蓓.沙美特罗替卡松气雾剂对小儿哮喘发作期血清IgE,NO及SOD 水平影响研究[J].中国生化药物杂志,2016,36(3):61-63. ZHANG Zhe,ZHANG Wenxi,ZHAO Bei.Effect of salmeterol aerosol on se rum IgE, NO and SOD levels in children with asthma attack[J].Chinese Journal of Biochemical Pharmaceutics,2016,36(3):61-63.
[13]王寒梅,孙仁山.IgE相关变应性疾病治疗研究进展[J].临床军医杂志,2017, 45(8):872-874. WANG Hanmei,SUN Renshan.Progress in the tre-atment of IgE related a llergic diseases[J].Clinical Journal of Medical Officers,2017,45(8):872-8 74.
[14]廖惠贞,刘新华,雷子庆,等.过敏原IgE检测在儿童常见过敏性疾病诊治中的临 床价值[J].临床医学工程,2017,24(7):1031-1032. LIAO Huizhen,LIU Xinhua,LEI Ziqing,et al.Clinical value of aller gen IgE detection in the diagnosis and treatment of common allergic diseases in children[J].Clinical Medical Engineering,2017,24(7):1031-1032.

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备注/Memo

备注/Memo:
基金项目:咸宁市中心医院、同济咸宁医院院级重点科研项目(项目 编号2016XYB003,2017XYA004)。
作者简介:朱建光(1982-),男,研究生,主管检验技师,研究方 向:免疫与分子诊断,E-mail:122775297@qq.com。
通讯作者:郑曦,男,主任技师,研究方向:临床实验室诊断 ,E-mail:66173738@qq.com。
更新日期/Last Update: 2019-02-28