[1]王晟,陈乐.咳嗽变异性哮喘患儿布地奈德吸入剂与孟鲁斯特钠联合治疗对血清IL-6,TNF-α,TGF-β和IgE水平影响及作用机制研究[J].现代检验医学杂志,2019,34(01):137-141.[doi:10.3969/j.issn.1671-7414.2019.01.036]
 WANG Sheng,CHEN Le.Effects of Budesonide Inhalation Combined with Montelukast Sodium on Serum IL-6,TNF-α,TGF-β1 and IgE Levels in Children with Cough Variant Asthma and Its Mechanism[J].Journal of Modern Laboratory Medicine,2019,34(01):137-141.[doi:10.3969/j.issn.1671-7414.2019.01.036]
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咳嗽变异性哮喘患儿布地奈德吸入剂与孟鲁斯特钠联合治疗对血清IL-6,TNF-α,TGF-β和IgE水平影响及作用机制研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
137-141
栏目:
检验与临床
出版日期:
2019-02-28

文章信息/Info

Title:
Effects of Budesonide Inhalation Combined with Montelukast Sodium on Serum IL-6,TNF-α,TGF-β1 and IgE Levels in Children with Cough Variant Asthma and Its Mechanism
文章编号:
1671- 7414(2019)01-137-05
作者:
王晟1陈乐2
(1.上海市宝山区罗店医院 儿科,上海201908; 2.上海儿童医学中心急诊科,上海200127)
Author(s):
WANG Sheng1CHEN Le2
(1.Department of Pediatrics,Luodian Hospital of Shanghai Baoshan District,Shanghai 20 1908,China; 2.Department of Emergency,Shanghai Children’s Medical Center,Shanghai 200127,China)
关键词:
孟鲁斯特钠咳嗽变异性哮喘炎症细胞因子转化生长因子 -β1免疫球蛋白E
分类号:
R562.25;R392.11
DOI:
10.3969/j.issn.1671-7414.2019.01.036
文献标志码:
A
摘要:
目的研究布地奈德吸入剂与孟鲁斯特钠联合治疗方案对咳嗽变异性哮喘患儿白介素-6(I L-6)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)和免疫球蛋白E(IgE) 水平影响及作用机制。方法选取2017年4月~2018年8月上海市宝山 区罗店医院咳嗽变异性哮喘婴幼儿116例,采用单双号法,分为研究组和对照组,每组58例 。对照组婴幼儿采用糖皮质激素类药物,如布地奈德粉吸入剂;观察组采用布地奈德粉吸入 剂联合孟鲁司特钠咀嚼片;观察两组婴幼儿治疗前(T0)、治疗2周(T1)、4周(T2)和8周(T3) 时咳嗽症状评分和IL-6,TNF-α,TGF-β1和IgE水平变化及咳嗽开始缓解、完全缓解时 间。结果T1,T2和T3每个时刻,研究组日间症状及夜间症状评分均 低于对照组,差异均有统计学意义( t=5.109~7.649,均P <0.05)。且T0,T1,T2,T3 时,两组婴幼儿日间症状评分、夜间症状评分均呈现下降趋势,与同组间比较,差异有统计 学意义( F=4.204~6.610,均P <0.05)。研究组咳嗽症状开始缓解时间及完全缓解时间 均少于对照组,差异有统计学意义( t=5.906,4.885,均P <0.05)。T1,T2和T3每个 时刻,研究组IL-6,TNF-α,TGF-β1和IgE水平均低于对照组,差异均有统计学意义( t IL-6=3.953~4.204, t TNF-α=3.911~4.825, t TGF-β 1=4.140~4.300, t IgE=5.103~5,870,均 P <0.05)。且T0,T1,T2,T 3时,两组婴幼儿IL-6,TNF-α,TGF-β1和IgE水平均呈现下降趋势,与同组间比较,差 异有统计学意义( F=3,901~6.175,均P <0.05)。结论布地奈 德吸入剂与孟鲁斯特钠联合治疗方案通过降低咳嗽变异性哮喘婴幼儿炎症细胞因子,TGF- β1,IgE水平能有效减轻气道炎症反应,治疗效果确切,为临床规范化治疗提供了一种新 路径,值得扩大样本深入研究。
Abstract:
Objective To study the combination of budesonid e inhaler and montelukast sodium in interleukin-6 (IL-6),tumor necrosis fact or-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in children with cough variant asthma.The influence of β1),immunoglobulin E (IgE) levels and mechanism of action.Methods A total of 116 infants with cough variant asthma from April 2017 to August 2018 were enrolled in Luodian Hos pital of Shanghai Baoshan District in Shanghai.The study was divided into study g roup and control group,with 58 cases in each group.In the control group,gluco corticoids (such as budesonide powder inhaler) were used.The observation group was treated with budesonide powder inhalation combined with montelukast sodium c hewable tablets.The two groups of infants were treated before treatment (T0),t reatment cough symptom scores and changes in inflammatory cytokines,TGF-β1,I gE levels,and cough start remission and complete remission time at 2 weeks (T1) ,4 weeks (T2) and 8 weeks (T3).Results At each time of T1,T2 and T3,the daytime symptoms and nocturnal symptoms scores of the study g roup were lower than the control group and the differences were statistically si gnificant ( t =5.109~7,649,all P <0.05).At the time of T0,T1,T2 and T3,the daytime symptom scores and nocturnal symptom scores of the infants in b oth groups showed a downward trend.Compared with the same group,the difference was statistically significant ( F =4.204~6,610,all P <0.05).The time to complete the remission of the cough symptoms and the time of complete remiss ion were lower in the study group than in the control group,and the difference was statistically significant ( t =5.906~4.885,all P <0.05).At each ti me of T1,T2 and T3,the levels of IL-6,TNF-α,TGF-β1 and IgE in the study group were lower than those in the control group,and the differences were stat istically significant ( t IL-6=3.953~4.204, t TNF-α=3.911 ~4.825, t TGF-β1=4.140~4.300, t IgE=5.103~5,870,均 P <0.05).At the time of T0,T1,T2 and T3,the levels of IL-6,TNF-a,TGF- β1 and IgE in the two groups showed a downward trend.Compared with the same gr oup,the difference was statistically significant ( F =3.901~6.175,all P <0.05).Conclusion The combination of montelustner reg imen can effectively reduce airway inflammation by reducing the levels of inflam matory cytokines,TGF-β1 and IgE in infants with cough variant asthma.The the rapeutic effect is clear and provides a new path for clinical standardized treat ment.It is worth expanding the sample to conduct in-depth research.

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备注/Memo

备注/Memo:

作者简介:王晟(1976-),男,大学本科,主治医师,研究方向:儿科疾病的诊治研究,E-mail: drw 1990@126.com。
更新日期/Last Update: 2019-02-28